Ribosome Biogenesis and Function in Cancer: From Mechanisms to Therapy
#cancerresearch
A comprehensive review by PhD student Kezia Gitareja as part of a special issue www.mdpi.com/3428496
Register for the Australian Cell Cycle, DNA Repair & Telomere Meeting in beautiful Melbourne October 19-22, 2025. Plenty of slots for selected abstracts and posters. High praise last time from Piotr Sicinski: "en par with a Gordon conference for science and interaction"
www.australiancellcycle.org
Single-cell analysis reveals the extent of genome doubling in ovarian cancer, its variability and its role in enabling tumours to evade the immune system
go.nature.com/4kJLAjZ
Applications for this position will close on Friday 30 June
So if you or anyone you know might be interested in applying, time to get your skates on!
Hope you get some rest! Safe travels the rest of the way!
😆 I made up for it by walking 20k around Copenhagen in one day- and surprisingly, I liked the Little Mermaid!
Haha.. No sword-wielding ceremony, but plenty of delicious Danish pastry
Had the pleasure of serving as an examiner for a PhD thesis defence and visiting the Danish Cancer Institute in Copenhagen 🧬 Two days filled with brilliant science & thoughtful discussion.
Science thrives through connection- across labs, disciplines, and borders. #AcademicTravel
Copying @k8weeks.bsky.social
International Women's Day is the perfect opportunity to connect with #womeninSTEMM and our allies on this platform!
Hello @gregorykj.bsky.social @drmlhalls.bsky.social @louisepurton.bsky.social @karinayaniv.bsky.social @drzoewaller.bsky.social @elainesanij.bsky.social
Join us next week for the Penny Taylor Oration with keynote by Prof Brad Nelson from British Columbia Cancer Research Centre on deciphering and re-engineering the immune response to cancer.
In person and online, register here: www.trybooking.com/events/landi...
If you see this, quote with flowers from your gallery. 🌿
It’s from a neighbour’s garden and I admire it every time I walk past
Thrilled to share the first preprint from @elainesanij.bsky.social lab as my first post on @bsky.app! 🧬🎉 Honored to co-lead this work with Jiachen Xuan and so proud of our amazing team’s efforts to drive and inspire future research! 🙌
7/ A huge thank you to my incredible team, co-1st authors
Dr Ruofei Liu, PhD student Anthony Xuan and collaborators who made this possible. I can’t wait to see how these insights shape future research! 🙌
6/ Using a small CRISPR-Cas9 synthetic lethal screen with Pol I inhibitors, we uncovered a protective role for RAD54L in nucleolar DDR. Loss of RAD54L increases R-loops and rDNA damage, disrupting nucleolar structure and sensitizing cells to PARP and RNA Pol I inhibitors. 🧬🛠️
5/ We uncovered that upon rDNA damage, nucleolar Pol II binds to intergenic rDNA sequences, generating R-loops. These R-loops recruit DDR factors, playing a pivotal role in the early response to rDNA damage and the nucleolar DDR response. 🧬✨
4/ We identified early changes in nucleolar-nucleoplasmic proteome localisation upon rDNA damage and uncovered replication stress signatures involving chromatin remodelling, transcription-replication conflicts, and DNA repair pathways. 🌀
3/ In this study, we profiled the nucleolar proteome and chromatin landscape of stalled replication sites upon rDNA damage. This allowed us to identify the early steps of nucleolar DDR and provided a valuable resource for investigating the response to replication stress at rDNA.
2/ rRNA genes are transcribed by up to 150 RNA Pol I enzymes simultaneously, creating a challenge for replication machinery. The rDNA loci are hotspots for DNA damage, but the dynamics of repair in these regions are not fully understood. 🧬⚡️
1)🚨 Excited to share the first preprint from my lab
at SVI as it celebrates 4 years! 🎉 This work defines local surveillance mechanisms within the nucleoli that activate the DNA damage response (DDR) when DNA damage occurs at rRNA genes (rDNA). www.biorxiv.org/content/10.1...
1/Delighted to announce the newest paper from our lab, “Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage”, is out today in @naturecellbiology.bsky.social, www.nature.com/articles/s41....
Novel AI Tool “Sees” Gene Expression in Tumor Biopsy Images
"SEQUOIA, a linearized transformer model that predicts cancer transcriptomic profiles from whole slide images."
Open access
www.nature.com/articles/s41...
News
www.insideprecisionmedicine.com/topics/oncol...
Congrats to you and the team on a great year! 👏
Congrats Irene 🎉 I’m glad we managed a quick celebration! Here’s to many more great papers and achievements 🥂
Now new and improved and out on Genome Medicine!
link.springer.com/article/10.1...
Delighted to publish my new molecular animation:
DNA Break Repair by Homologous Recombination
youtu.be/Xe-83tBcxhs
