Check out the awesome highlight (+ video) of our recent work on the #biophysics of #metastasis published by Le Point, by O.HERTEL
🔗 lnkd.in/eywzr8kn
🖥️ dai.ly/xa0dwds
Such a blast to see our #zebrafish 🐠 experiments making the (web) front page (but there are also 🐁 ones in the original paper 😜)
Awesome 👏 work !
💡 Interested in mechano-immunology (or biology of adult B-ALL) ?
💥 We have an #MSCA postdoctoral fellowship offer for you
@ec.europa.eu
🖥️ : euraxess.ec.europa.eu/jobs/hosting...
🏙️ Where ? In beautiful #Strasbourg #CRBS @inserm.fr @unistra.fr
🥼 Interested ?
📧 jacky.goetz@inserm.fr
💡 Interested in mechano-immunology (or biology of adult B-ALL) ?
💥 We have an #MSCA postdoctoral fellowship offer for you
@ec.europa.eu
🖥️ : euraxess.ec.europa.eu/jobs/hosting...
🏙️ Where ? In beautiful #Strasbourg #CRBS @inserm.fr @unistra.fr
🥼 Interested ?
📧 jacky.goetz@inserm.fr
France should also not forget to preserve their best minds !
Tumor cell in the maze of the lung vasculature in a mouse.
A #research team investigated how the mechanical properties of tumor cells influence their metastatic pathway.
🔑 🔍: Viscosity – rather than elasticity – determines how tumor cells invade surrounding tissue.
👉 mpzpm.mpg.de/news/news-de...
📸 V. Gensbittel, J. Goetz
#science #biophysics #metastasis
Thank you 🙏
@inserm.fr @unistra.fr
@inserm.fr @unistra.fr
New study finds cancer spread driven by how “thick” tumour cells are
🧬 New study in Nature finds cancer spread depends on how “thick” tumour cells are. Higher cell viscosity helps them survive blood flow and escape into new tissues - a key step in metastasis. 🔬 www.nature.com/artic... #CancerResearch #Science #Health
Cell viscosity influences haematogenous dissemination and metastatic extravasation of tumour cells
go.nature.com/4jZ8OUu
🙏
💡 Have you ever wondered how #circulating #tumor cells squeeze through narrow #capillaries during hashtag#metastasis ?
💥 We did, check out our latest publication just out #NatureMaterials: rdcu.be/eZHxJ
Un plaisir aussi de voir Elodie Marchal et Laurie Nemoz-Billet jouer avec notre cytométre de déformabilité développé par Jochen Guck et son équipe Martin Kräter #Rivercyte, et Laetitia PAULEN à la paillasse
Un plaisir d'être mis en lumière, ainsi que notre #CRBS @inserm.fr @unistra.fr et sa plateforme #PICSTRA orchestrée par #PascalKessler que nous avons pu labelliser #FBI et #GIS IBiSA (ici Louis Bochler et Zeynep YESILATA devant un de ses microscopes)
Merci #France3Alsace @francetv.bsky.social et en particulier #MarieCoulon pour ce nouveau reportage sur nos tout derniers travaux dans la Région Grand Est
📺 (start at 00:12:45) www.france.tv/france-3/gra...
Merci 🙏 @unistra 😊
Pour former des métastases, les cellules cancéreuses doivent franchir une course d’obstacles qui exige des propriétés physiques spécifiques. Une étude montre que leur viscosité joue un rôle crucial, mais pas à toutes les étapes de la progression métastatique.
@goetzjacky.bsky.social @inserm.fr
Un grand merci @alexandramaz.bsky.social pour ce highlight, un vrai plaisir de travailler et d'échanger avec vous !
@inserm.fr @unistra.fr
Pour former des métastases, les cellules cancéreuses doivent franchir une course d’obstacles qui exige des propriétés physiques spécifiques. Une nouvelle étude montre que leur viscosité joue un rôle crucial, mais paradoxalement, pas à toutes les étapes de la progression métastatique.
💰 Who funded it ?
@inserm.fr
@unistra.fr
Ligue contre le cancer
Institut national du cancer
@fondationarc.bsky.social
@frm-officiel.bsky.social
@fondationdefrance.bsky.social
Cancéropôle Est
Région Grand Est
We received precious help from many collaborators, especially from Jochen Guck and his team including Martin Kräter Salvatore Girardo, but also from Daniel Balzani Daniel J. Müller
@inserm.fr @unistra.fr @maxplanck.de @ethz.ch #UnivBochum @nkinl.bsky.social
#PIC-STRA #CRBS
👩🔬 👨🔬 Who ?
This study has been initiated many years back in the lab when we realized, as many in the field, that CTCs can also get "stuck" in vessels. It was mostly driven by Valentin Gensbittel, whose wizardy was shaped by many members in the lab (and outside), including @naelosmani.bsky.social
📊 In summary : mechanically adaptable tumor cells are most likely to complete the metastatic cascade
2️⃣ Once arrested, they perform better during #extravasation, by endoctrinating
the endothelium ⚙️ The more viscous, the better
3️⃣ Once extravasated, disseminated cells with low viscosity were better at initiating metastatic outgrowth ⚙️ The more viscous, the better
🔬 What have we found ?
In a nutshell, we show that #tumor #cell #viscosity acts as a rheostat of multiple important steps of hashtag#metastasis.
1️⃣ Circulating tumor cells exploit their viscous properties to reach mechanically-constraining capillaries ⚙️ The less viscous, the better
💡 Have you ever wondered how #circulating #tumor cells squeeze through narrow #capillaries during hashtag#metastasis ?
💥 We did, check out our latest publication just out #NatureMaterials: rdcu.be/eZHxJ
What ? We successfully developed and validated isoform-specific intrabodies targeting Ral oncoproteins. Some of them successfully perturb RalA-specific functions in cells and offer a promising therapeutic strategy for significantly suppressing tumor growth and metastasis in vivo.
Who ? Awesome job by #CharlotteSarre, @katkajerabkova.bsky.social and @hyennev.bsky.social in our lab. Charlotte was a shared post-doc with Pierre's team.
