Also today I’m presenting the latest #PAINAP data at #EPC2025… Exploring pain intensity and outcomes of AP and just recently accepted for publication in #BJS ⚡️Sanjay Pandanaboyana

💥1st global 🦠trial on AP

🥳We’re thrilled to announce that with the start of recruitment in 🇦🇺, P-MAPS II has officially gone 🌍! With over 300 pat. enrolled

👉AIM: 700 pat.

🙏for incredible commitment and collaboration of all P-MAPS II members

✂️ Arterial resection and divestment 🔟 year comparative study in @bjsopen.bsky.social

🇯🇵 Analysis of 200 PDAC + artery

👗 Divestment (120 cases) most used in first 5 years

🎖️Last 5 years ⬆️ Neoadjuvant chemo + resection ⬇️ complications 👍

academic.oup.com/bjsopen/arti...

Very nice study! One of the @myueg.bsky.social abstracts presented during the „best of“ #UEGW2024 session at #DDW2025

@jacobhamm.bsky.social @esge-news.bsky.social @demadaria.bsky.social @marcbesselink.bsky.social @malinasund.bsky.social @maloehr.bsky.social @endoscopy.bsky.social @asgeendo.bsky.social

👉almost 1000 patients included

👉pigtail through LAMS seems beneficial

👉post-hoc analysis revealed compound and dosage effect of PPI

🥳👉Very happy to share our latest paper published in Endoscopy

🙌Great team effort from 17 🇪🇺centers

PPI 💊 intake lead to ↗️ LAMS occlusion and ↗️ necrosectomy rates addressing WONs but 🩸complication same as No PPI

What is your practice?

tinyurl.com/2ubsu5u4

🆕🔥Updated systematic review & meta-analysis (+REMAP CAP)
30 RCTs,N=7519
Corticosteroids probably 🔽 short-term mortality 🔽the need for invasive mechanical ventilation & likely 🔽duration of ICU stay in adult pts hospitalised with non viral CAP #idsky #EMIMCC
link.springer.com/article/10.1...

Cefazolin versus Antistaphylococcal Penicillins for the Treatment of Methicillin-Susceptible Staphylococcus aureus Bacteremia: A Systematic Review and Meta-Analysis There is debate on whether cefazolin or antistaphylococcal penicillins should be the first-line treatment for methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia. Ongoing trials are invest...

🆕💫 Systematic Review and Meta-Analysis
30 observational studies( SNAP & CloCeBa not included)
N: 3869
Cefazolin versus Antistaphylococcal Penicillins for the Treatment of MSSA Bacteremia #idsky
www.clinicalmicrobiologyandinfection.com/article/S119...

Proud to receive the prize for the best oral presentation of the International Biliary Pancreatic Meeting 2025 in Seoul, validation of PAN-PROMISE score for its application in RCTs in acute pancreatitis
Thanks to the scientific committee!

Hospitalized patients with bloodstream infections can be effectively treated with antibiotics for just 7 days instead of 14.

by None None, Daneman N (...) Fowler RA et 89 al. in N Engl J Med #MedSky

📖 read the article: https://www.nejm.org/doi/10.1056/NEJMoa2404991

Aspirin is associated with lower risk of pancreatic cancer and cancer-related mortality in patients with diabetes mellitus Background Patients with type 2 diabetes mellitus (T2DM) have higher pancreatic cancer (PC) risk. While aspirin has chemopreventive effects on digestive cancers, its effect on PC among patients with T...

Aspirin is associated with lower risk of pancreatic cancer and cancer-related mortality in patients with diabetes mellitus

gut.bmj.com/content/74/4...

Is there a role for neoadjuvant chemo for 🍇 invasive IPMN ?!

🌎 1k resected only 7% after NAT

👍 BR / LAPC no worse OS after NAT

🧪 CA19.9 indicates “biological” treatment effect

👉https://journals.lww.com/annalsofsurgery/abstract/9900/neoadjuvant_chemotherapy_for_intraductal_papillary.1220.aspx

Even better

@laurennephewmd.bsky.social is actively building interventions to reduce disparities by involving the patients in their design

journals.lww.com/hepcomm/full...

Histo (2025)

Just published 🔥
IDSA 2025 Clinical Practice Guideline Update On Histoplasmosis: Treatment of Asymptomatic Histoplasma Pulmonary Nodules (Histoplasmomas) and Mild or Moderate Acute Pulmonary Histoplasmosis in Adults,Children & Pregnant People #IDsky
www.idsociety.org/practice-gui...

The 12-Year Experience of the Hungarian Pancreatic Study Group The Hungarian Pancreatic Study Group (HPSG) was established with the aim of advancing pancreatology. Our summary outlines the methodologies, key results, and future directions of the HPSG. Methodologi...

Proud to share the work of the Hungarian pancreatology group led by my friend Peter Hegyi

Collaborative research, search for answers to relevant questions, and international scope
👇🏻👇🏻👇🏻
www.mdpi.com/2077-0383/14...

Response to electroconvulsive therapy is associated with a more diverse oral microbiome- a prospective longitudinal cohort pilot study - PubMed Recently it has been shown that psychiatric disorders are associated with changes in the host microbiome. Little is known about the association of electroconvulsive therapy (ECT) and microbiome altera...

Happy to see our pilot study published in Eur Arch Psychiatry Clin Neurosci.

👄🦠Oral microbiome diversity is associated with response to ⚡🧠 electroconvulsive therapy in treatment resistant depression.

🙏🙌Wonderful cooperation with our psychiatric department

👉 pubmed.ncbi.nlm.nih.gov/39953120/

Climate change contributes to the spread of Histoplasma & Blastomyces spp!
🆕💫 Review article @cmicomms.bsky.social @germatologist.bsky.social @mikescolarici.bsky.social
Histoplasmosis & Blastomycosis Progress & Possibilities
Similarities & Differences #idsky
www.sciencedirect.com/science/arti...

Rethinking the “Pan-Culture”: Clinical Impact of Respiratory Culturing in Patients With Low Pretest Probability of Ventilator-Associated Pneumonia AbstractBackground. Respiratory cultures are often obtained as part of a “pan-culture” in mechanically ventilated patients in response to new fevers or leu

Rethinking the “Pan-Culture”:
Respiratory cultures are often obtained as part of a “pan-culture” in mechanically ventilated patients in response to new fevers or leukocytosis, despite an absence of clinical or radiographic evidence suggestive of pneumonia #idsky
academic.oup.com/ofid/article...

Thanks to @absteward.bsky.social for finding 2 RCTs of shorter (1 IM dose) vs. longer (3 weekly IM doses) of PCN for "Early Syphilis"! Added to the Shorter Is Better Table. 23 distinct conditions now reported in the table!
References at
www.bradspellberg.com/shorter-is-b...

Adenoma Detection Rates by Physicians and Subsequent Colorectal Cancer Risk This observational study investigates the association of adenoma detection rates among physicians who perform colonoscopy and postcolonoscopy colorectal cancer incidence.

Improving adenoma detection rates in physicians significantly reduces colorectal cancer risk for patients with lower baseline detection rates.

by Pilonis ND, Spychalski P (...) Kaminski MF et 9 al. in JAMA #MedSky

📖 read the article:

How do costs of #robot 🤖 vs open #pancreatoduodenectomy compare?

588 pts A’dam🇳🇱 (214 RPD, 374 OPD)

⛔️Costs €4,804 ⬆️ RPD
✅As outcomes RPD improved in the 2nd half: cost per RPD €11,058 less
🔑 Costs in the 2nd half RPD vs OPD comparable (€21,778 vs. €21,013)

▶️ journals.lww.com/annalsofsurg...

A Randomized Controlled Trial of Efficacy and Safety of Fecal Microbiota Transplant for Preventing Recurrent Clostridioides difficile Infection Clostridioides difficile infection (CDI) is the most common cause of healthcare–associated infections in US hospitals, with 15%–30% of patients experiencing recurrence.

A Randomized Controlled Trial of Efficacy and Safety of Fecal Microbiota Transplant for Preventing Recurrent Clostridioides difficile Infection

Volume Matters: Examining The Management Of Necrotizing... : Annals of Surgery morbidity, and mortality. Methods: Adult patients admitted with NP were identified in the 2016-2019 Nationwide Readmissions Database 2016-2019. Hospital volume cutoffs were defined by tertiles of t...

Management of Necrotizing Acute ⚡️ Pancreatits in the modern era

🇺🇸 25K acute pancreatitis (20% necrotizing)
🪡 14% underwent procedural intervention

🏥 Low volume > open necrosectomy vs. MI / endoscopy
👍 High volume > improved survival / resources

journals.lww.com/annalsofsurg...

#SurgSky #HPBSky

Antibiotic prophylaxis for SBP in cirrhosis has been standard of care since the 1990s—but is the evidence strong enough to support it? Time to rethink this practice!
Excellent commentary @cidjournal.bsky.social
#IDsky #ASEPTICRCT academic.oup.com/cid/article/do…academic.oup.com/cid/advance-...te

🙏 @paulsaxmd.bsky.social for the invitation to write this from a #liversky and #IDsky perspective @cidjournal.bsky.social
Totally agree the approach needs to shift! @vculiver.bsky.social @idsainfo.bsky.social @easlnews.bsky.social @varesearch.bsky.social

2️⃣0️⃣2️⃣4️⃣ Pancreas Wrapped🎄

🔟 October 🔥 Clinical and Financial Validation of the ISPGS definition of PPAP

🌍 Prospective International study on 3000 PD

🧪 POH 24% ⚡️ PPAP 7%

🏥 PPAP grading influence LOS, ICU, readmissions, costs

journals.lww.com/annalsofsurg...

Coupling antigens from multiple subtypes of influenza can broaden antibody and T cell responses The seasonal influenza vaccine contains strains of viruses from distinct subtypes that are grown independently and then combined. However, most individuals exhibit a more robust response to one of the...

Flu Vaccine Response Boosted by Coupling Antigens from Multiple Subtypes. #Science

"New research presents a novel vaccine platform that improved protection against diverse influenza subtypes."

Science
www.science.org/doi/10.1126/...

News
www.genengnews.com/topics/infec...

Big stage for #pancreaticcancer yesterday on #WPCD in Brussels with a panel discussing what is needed and where to go @eortc.bsky.social @ueg @pce
We need more awareness, more research, patient involvement to push policy