Athanasios Alexandris, MBChB

Speaking Out for the Blind Episode 380- Mammals Restoring Vision Popular Mechanics says that mammals may not have ocular regeneration superpowers. But a new study shows that nature might have a couple of tricks up its sleeve. Joining me to talk about the recent stu...

Thanks to Speaking Out for the Blind for the opportunity to talk about our work on collateral sprouting and recovery after injury in the visual system. speaking-out-for-the-blind.pinecast.co/episode/c88d...

Thrilled that our new paper is now out !

It’s @a-alexandris.bsky.social talking at the Retinal Ganglion Cell Meeting about his work in axonal degeneration.

For more, check our paper. Grateful for the collaborative effort between the Brain Injury & Degeneration Center, the Calabresi Lab (@pcalabresi.bsky.social, @thomasgarton.bsky.social), and Dr. Marjan Gharagozloo at @jhu.edu

And a putative leukocyte wreaking havoc in the optic nerve nerve.

We also explored ultrastructural changes by EM. Here’s a favorite: an axon (blue) in the process of losing its myelin.

To study axonopathy and degeneration, among others we developed a single-axon resolution IF method on 75 nm resin-embedded optic nerve sections. This approach also revealed a striking peripheral-to-central gradient of axon loss.

Temporal progression of axonal degeneration in the visual system in experimental autoimmune encephalomyelitis: Insights from high-resolution neuropathology Abstract. Multiple sclerosis (MS) is characterized by inflammation, demyelination, and axonal degeneration in the CNS, leading to progressive neurological

In our new study (doi.org/10.1093/jnen...), we map high-resolution changes in the visual system in the EAE model of MS. Early deficits in axonal transport and function occur before overt axon or RGC loss, highlighting a window for axon-targeted neuroprotection in demyelinating disease. 1/5

The NLRP1 inflammasome is an essential and selective mediator of axon pruning in neurons | EMBO reports imageimageAxon pruning, the selective degeneration of axons, requires many apoptotic proteins, though it is distinct from apoptosis. This study identifies two inflammasome proteins, Caspase-1 and NLRP...

doi.org/10.1038/s443...

Diffuse Axonal and Vascular Pathology in the Gyrencephalic Brain after High-Energy Blunt Injury: Clinicopathological Correlations Involving the Brainstem | Journal of Neurotrauma Traumatic brain injury (TBI) after high-energy, behind helmet blunt trauma (BHBT) is an important but poorly understood clinical entity often associated with apnea and death in humans. In this study, ...

Our new paper is out! Even with helmet protection, high-energy blunt trauma can lead to fatal respiratory failure. Our study maps specific brainstem injury patterns, revealing critical implications for #TBI & protection. Patterns of #vascularinjury ≠ #axonalinjury www.liebertpub.com/doi/10.1089/...