Javi Ibarrondo

B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes Using a dual-recombinase fate-mapping system to trace late-entry invader B cells in germinal centers, Zhou et al. show that across vaccination and influenza infection, invaders preferentially generate...

B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes: Immunity www.cell.com/immunity/ful... 🧪

AI might be the next stage of our natural evolution: A cancer neuroscience perspective Understanding the interactions between cancer and the nervous system may require AI-based analytics.

AI might be the next stage of our natural evolution: A cancer neuroscience perspective | Science Signaling www.science.org/doi/10.1126/... 🧪

FDA finds little evidence that the generic drug leucovorin can help people with autism FDA officials say evidence only supports the drug's use in patients with a specific genetic disorder.

The Food and Drug Administration on Tuesday approved a generic medication for a rare brain disorder, while walking back suggestions by President Donald Trump and other administration officials that the drug showed great promise for people with autism. https://to.pbs.org/4bAsKu9

FDA approves new use of synthetic vitamin B9 — but not for autism symptoms Federal officials touted leucovorin as a potential treatment for autism symptoms. But the FDA said there isn’t data to approve it for that purpose.

The FDA announces the drug leucovorin may be used for cerebral folate deficiency, a rare neurological condition characterized by low levels of vitamin B9 in the brain.

Neutralization of acyl-CoA-binding protein attenuates glucocorticoid-mediated suppression of cancer immunosurveillance | PNAS www.pnas.org/doi/10.1073/... 🧪

Elites moved toward democrats more than nonelites moved away: Income, education, and occupational class in US presidential elections, 1980–2020 | PNAS Recent discussion of voting in US elections claims a strong movement of White working-class voters away from voting for Democrats, with much discus...

Elites moved toward democrats more than nonelites moved away: Income, education, and occupational class in US presidential elections, 1980–2020 | PNAS www.pnas.org/doi/10.1073/... 🧪

U.S. agency will devote $144 million to studies that slow aging, extend quality of life ARPA-H will “build the train tracks” for first large clinical studies of aging interventions

U.S. agency will devote $144 million to studies that slow aging, extend quality of life | Science | AAAS www.science.org/content/arti... 🧪

NASA administrator talks to Science about studying the Moon, Mars—and Earth Jared Isaacman says agency may accelerate lunar science program and could tackle a new Mars mission in 2028

NASA administrator talks to Science about studying the Moon, Mars—and Earth | Science | AAAS www.science.org/content/arti... 🧪

An Antifungal with a Novel Mechanism of Action Discovered via Resistance Gene-Guided Genome Mining Invasive fungal infections claim over two million lives annually, a problem exacerbated by rising resistance to current antifungal treatments and an increasing population of immunocompromised individu...

An Antifungal with a Novel Mechanism of Action Discovered via Resistance Gene-Guided Genome Mining | ACS Central Science pubs.acs.org/doi/10.1021/... 🧪

Nanotechnology in Cancer Therapy: How Nanoparticles Are Shaping the Future of Personalized Treatment Nanotechnology has transformed cancer research, with nanoparticles emerging as powerful platforms for therapy and diagnosis due to their tunable physicochemical properties and biocompatibility. Nanoparticles enable targeted drug delivery, improved pharmacokinetics, and reduced systemic toxicity compared with conventional therapies while also supporting molecular imaging and theragnostic applications. More than eight nanoparticle-based formulations are currently FDA/EMA approved for oncology, highlighting the clinical relevance of nanomedicine. Despite these advances, clinical translation remains limited by biological and technical challenges, including variability in the enhanced permeability and retention effect, insufficient tumor penetration, and low manufacturing scalability. This review primarily focuses on preclinical and translational nanomedicine with selected clinical examples. We summarize recent progress in major nanocarrier classes, including liposomes and polymeric, inorganic, and hybrid nanoparticles, and their roles in cancer therapy. These findings underscore that effective nanotherapeutic strategies must be informed by tumor biology rather than relying on passive targeting alone, that combination and stimuli-responsive platforms represent the most promising therapeutic avenues, and that meaningful clinical translation will depend on overcoming tumor heterogeneity with patient-specific treatment options and achieving robust, reproducible manufacturing.

Nanotechnology in Cancer Therapy: How Nanoparticles Are Shaping the Future of Personalized Treatment | ACS Nano Medicine pubs.acs.org/doi/10.1021/... 🧪

Formation and Transformation of Micro(nano)plastics: Mechanisms and Environmental Health Implications Micro(nano)plastics (MNPs; <5 mm plastic particles including nanoscale fractions) are increasingly recognized as pervasive environmental pollutants, with risks arising not only from their original emi...

Formation and Transformation of Micro(nano)plastics: Mechanisms and Environmental Health Implications | Environment & Health pubs.acs.org/doi/10.1021/... 🧪

Public communication alters private confidence Andreassen et al. demonstrate that confidence exhibited in public affects our private assessment of confidence.

Public communication alters private confidence: Current Biology www.cell.com/current-biol... 🧪

Career effects of preprints get mixed reviews from biomedical researchers | Science | AAAS www.science.org/content/arti... 🧪

Exclusive: US investigation points to likely US responsibility in Iran school strike, sources say Military investigators believe it is likely that U.S. forces were responsible for an apparent strike on an Iranian girls' school that killed scores of children on Saturday, two U.S. officials told Reu...

Reuters Exclusive

"U.S. military investigators believe it is likely that U.S. forces were responsible for an apparent strike on an Iranian girls' school."

"The strike would rank among the worst cases of civilian casualties in decades of U.S. conflicts in the ​Middle East."

Persistent antigen is essential for sustaining Leishmania major–specific memory CD4+ T cells and long-term immunity Persistent parasites may be key to lasting immunity because without them, memory CD4+ T cells fade and protection is lost.

Persistent antigen is essential for sustaining Leishmania major–specific memory CD4+ T cells and long-term immunity | Science Advances www.science.org/doi/10.1126/... 🧪

Trapped in declining occupations: Barriers to worker mobility in a changing economy Recent occupational restructuring is widening the mobility opportunity gap between workers in growing and declining occupations.

Trapped in declining occupations: Barriers to worker mobility in a changing economy | Science Advances www.science.org/doi/10.1126/... 🧪

‘Insane’ images depict ant species in stunning 3D New method for visualizing organisms opens the door for mass digitization efforts

‘Insane’ images depict ant species in stunning 3D | Science | AAAS www.science.org/content/arti... 🧪

NIH reneges on recognizing union for early career researchers The biomedical research agency says trainees in its labs are not “employees”

NIH reneges on recognizing union for early career researchers | Science | AAAS www.science.org/content/arti... 🧪

New HIV cure approach forces hidden virus into tripping immune sensor Strategy gains momentum after promising results in cell studies and infected people

New HIV cure approach forces hidden virus into tripping immune sensor | Science | AAAS www.science.org/content/arti... 🧪

Thirty-six solutions to stabilize Earth’s climate An updated visual assessment tool can bridge the gap between climate research and political action

Thirty-six solutions to stabilize Earth’s climate | Science www.science.org/doi/10.1126/... 🧪

Protein therapy with self-amplifying RNA Self-amplifying RNA improves heart function after myocardial infarction in mice and pigs

Protein therapy with self-amplifying RNA | Science www.science.org/doi/10.1126/... 🧪

Baby-to-baby strain transmission shapes the developing gut microbiome - Nature A metagenomic survey of babies attending the first year of nursery detected extensive baby-to-baby microbial strain transmission, pointing to social interactions in infancy as crucial drivers of infan...

www.nature.com/articles/s41... 🧪

Stem cells provide a potent treatment for frailty Elderly people with frailty, which affects up to one-quarter of over-50s, increased their endurance after a single dose of stem cells.

www.nature.com/articles/d41... 🧪

Physiological aging in three dimensions Aging is characterized by progressive structural and functional decline, driven partially by epigenetic alterations. While changes in DNA methylation, histone modifications, and chromatin accessibilit...

Aging and senescence alter 3D chromatin organization, including compartments, topologically associating domains (TADs), and enhancer–promoter interactions, leading to altered gene expression.

Physiological aging in three dimensions: Trends in Cell Biology www.cell.com/trends/cell-... 🧪

Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature Liver exercise factor GPLD1 rejuvenates blood-brain barrier integrity and reverses cognitive impairments in aging and Alzheimer’s disease models by targeting GPI-anchored proteins on brain endothelial...

Liver exerkine reverses aging- and Alzheimer’s-related memory loss via vasculature: Cell www.cell.com/cell/fulltex... 🧪

Many heat-stressed tropical insects are reaching their limits Vast study in Peru and Kenya confirms limited defenses against rising temperatures, redoubling climate concerns

Many heat-stressed tropical insects are reaching their limits | Science | AAAS www.science.org/content/arti... 🧪

GLP-1 drugs linked to lower addiction rates in large study of veterans The treatments appeared to help prevent a wide range of substance use disorders and reduce serious harms from existing ones

GLP-1 drugs linked to lower addiction rates in large study of veterans | Science | AAAS www.science.org/content/arti... 🧪

Distinct spatial organization governs oral mucosal immunity - Nature Immunology Moutsopoulos, Williams and colleagues show oral mucosal barrier tissues exhibit dynamic zonal immune cell environments, including tonic inflammatory features in healthy individuals and development of ...

www.nature.com/articles/s41... 🧪

Rapid elicitation of neutralizing Asn332-glycan-independent antibodies to the V3-glycan epitope of HIV-1 Env in nonhuman primates - Nature Immunology WIN332 is an HIV-1 Env protein designed to elicit a new class of Asn332-glycan-independent antibodies (type II) to the V3-glycan site of Env. WIN332 immunization rapidly induces type-II V3-glycan anti...

www.nature.com/articles/s41... 🧪