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Bryan Mackowiak

@bryanmackowiak

Assistant Professor at East Tennessee State University Quillen College of Medicine

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07.12.2023
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Latest posts by Bryan Mackowiak @bryanmackowiak

we built squeakpose studio. now there’s a preprint so i can stop explaining it in slides.

modern computer vision. ultra-fast training and inference. model-assisted labeling. analysis out of the box. real-time edge deployment on whole frames at 120 fps (which felt reasonable at the time).

27.01.2026 02:14 πŸ‘ 6 πŸ” 5 πŸ’¬ 1 πŸ“Œ 0
Post image

Lrat-Cre has long been used to mark Hepatic Stellate Cell

Take a look at Extrahepatic cells labelled in Lrat-Cre::NuTRAP🐭
Kidney
Adipose (GFP+)
Testis
Eye
Intestine (GFP+)πŸ”₯
Skeletal Muscle (GFP+)
Heart
Brain
Lung (GFP+)πŸ”₯

bioRxiv 2026
www.biorxiv.org/content/10.6...

17.01.2026 13:47 πŸ‘ 8 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0

Check out a new paper coming out of our lab published in @acerjournal.bsky.social!!

03.11.2025 14:03 πŸ‘ 2 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
Preview
Cyp2e1 deletion in mice increases sensitivity to ethanol‐induced motor impairment and escalation of drinking behavior in the chronic intermittent ethanol model This study investigates the impact of global Cyp2e1 knockout and wild-type mice to explore the effect of altered ethanol metabolism on behavior and gene expression. Knockout mice demonstrated altered...

Check out my new paper on how Cyp2e1 deletion results in increased sensitivity to ethanol-induced motor impairment and increased drinking escalation in a CIE model:
doi.org/10.1111/acer...

03.11.2025 13:54 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 2
Preview
Risk reshapes amygdala representation of choice Modifying behavior in response to changing environmental conditions is a crucial adaptive function. This capacity is exemplified when animals curtail pursuit of a valued outcome that risks being punis...

for anyone interested in the amygdala and risky decision-making, check out our new preprint: biorxiv.org/content/10.1...

amygdala neurons track reward-seeking actions, and punishment risk dramatically alters this function. lots of other (BLA-accumbens!) data included.

09.10.2025 13:52 πŸ‘ 21 πŸ” 9 πŸ’¬ 0 πŸ“Œ 1

I'm deeply honored to share that I've been awarded a 2025 NARSAD Young Investigator Grant from @bbrfoundation.bsky.social .

I'm so grateful to my mentors & BBRF for continuing to support early career researchers during this tumultuous time. It will mean everything to scientists like me. πŸ₯²

06.08.2025 12:34 πŸ‘ 60 πŸ” 4 πŸ’¬ 15 πŸ“Œ 0

Congrats!

06.08.2025 12:39 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Yup. Microsoft automatically switched me to the $99.99/year version with Spicy Autocomplete. You have to go all the way through "cancel subscription" to be presented these options and get the $69.99/year one you actually chose.

24.01.2025 14:09 πŸ‘ 3814 πŸ” 2239 πŸ’¬ 189 πŸ“Œ 217
Redirecting

Microsoft is going to price gouge you by adding their genAI to your subscription without your consent, and they are not transparent about how to avoid this bullshit.

Here's how to change your subscription back to "Classic" for a lower charge without Copilot: answers.microsoft.com/en-us/msoffi...

18.01.2025 00:49 πŸ‘ 3102 πŸ” 1750 πŸ’¬ 285 πŸ“Œ 307

Peripheral alcohol metabolism dictates ethanol consumption and drinking microstructure in mice

14.01.2025 02:59 πŸ‘ 4 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
A wasp drinking a beer

A wasp drinking a beer

Wasps love alcohol. They seek out alcoholic drinks, and survive even after drinking the equivalent of 5 L of vodka, because they are incredibly efficient at metabolizing ethanol, helped by duplication of their alcohol dehydrogenase gene. www.pnas.org/doi/10.1073/... #BedtimeScience 🍺🐝 πŸ§ͺ

25.11.2024 11:29 πŸ‘ 42 πŸ” 11 πŸ’¬ 3 πŸ“Œ 1