Horacio V. Guzman

more to come! #glycotime

This achievement reflects the outstanding teamwork and collaboration between the @icmabcsic.bsky.social , @uam.es , and @ifimacuam.bsky.social

#FrontCoverAlert #AdsorptionBiophysics #GlueLikeNature #compchemsky

Link to the paper: pubs.acs.org/doi/10.1021/...

Link to the code: github.com/pyF4all/2Dan...

The cover was created in (gluey) Blender by @willymenacho.bsky.social with key inputs from Antonio Bosch #ProudPI

What's the role of glycans during adsorption on polarizable surfaces? Our work shows "dual capacity" acting either as a glue that enhances glycoprotein adsorption strength through dynamic-tethering patterns or as a blocking element that prevents protein-surface interactions #compchem @pubs.acs.org

Congrats! It has been bookmarked 🧶

Characterizing the Conformational Dynamics of the Ribose Transporter B Protein in Escherichia coli: Enhanced Sampling via Multiple Force Fields We present a molecular dynamics simulation study of the E. coli ribose transporter protein B (RbsB), a conformationally labile protein found in the periplasm of the bacterium. The ribose transporter e...

Our latest paper in which we use multiple force fields to recover various conformations of the ribose transporter from E. coli. The work of DPhil student Nikolai Juraschko and postdoc Florencia Klein Rocha

pubs.acs.org/doi/full/10....

Awesome results, hand-to-hand with this discoveries, lots of biophysics still need to be developed.... more to come🧬 🧶 🪡!

bookmarked!

#PhDPosition open — #RibosomeBiology & #Translation QC
📍 JGU Mainz, Germany
🗓️ Apply by 10 Mar 2026 (or until filled)
🔗 Full details + project options:
👉 ak-winz.pharmazie.uni-mainz.de/jobs/

My little outlook on how our lungs 🫁 are like the sea 🌊 is finally out in Central Science. Thanks to the support from incredible mentors @rommieamaro.bsky.social and @kprather.bsky.social !!

bookmarked1

Bookmarked!

Those facts are mindblowing! Several region of Potosi limits with the Atacama desert are in distance not far, and have indeed awesome starry skies in common! The nonpolar map in 2D would be great to see as contour plots ,)

Amazing, however the driest, might be rather the Uyuni saltflats un Bolivia!? Cheers!

Congrats for the cool results, I am extremely interested in the transition from 3D right-handed helical motion to 2D clockwise .. I've bookmarked it! 🪱

p.s.: the magic link www.aidemos.meta.com/segment-anyt...

Not yet there for extracting a 3D model from a "picture image" and applying it to our #Proteins, #chompchmesky , #compchem; @Meta the protein was flatenned in the depth direction, otherwise would be great to track some Multiscale model AI mappings, and much more 🧬 🧶🪱

Thanks to the organizers for giving me the opportunity to present my lab' top-notch RNA models at multiple scales, including polymer physics(⚡ electrostatic and 🍦 mechanical properties) inputs and features of structural predictions with AI 🧵! #RNAtime #RNApuzzles #RNAmultiscaleSims #rnaProtInteract

Are you a postdoc stuck in the US?! Is your research stalled or are you in any way affected by the whims of that unfettered madman? Interested in MD simulations of large biomolecules?!

Consider joining me at the University of Freiburg!

uni-freiburg.de/frias/call-f...

BA.3.2 in Rheinland Pfalz 🇩🇪... most likely Hessen too... #compchemsky, #compchem, #goViralAgain #physVirology #compVirology

good timing for the new project in the BIM Lab!!! thanks for sharing

**Job Alert** Exciting postdoc position available: theoretical and experimental cryo-EM studies of flexible biomolecules. Competitive salary, collaborative environment at NYSBC and Flatiron Institute. Please share!! and contact: pcossio@flatironinstitute.org

The full scope of glycan dynamics in modulating surface affinity will be presented shortly (soon)! # 𝔾𝕝𝕪𝕔𝕠-𝕒𝕕𝕤𝕠𝕣𝕡𝕥𝕚𝕠𝕟 #glycoAdsorptionTime 2++

The polarizable surface provides the perfect 𝔽𝕠𝕞𝕚𝕥𝕖 model to spatially & rapidly quantify the effect of mutations at the interface, by identifying how singular &/or collective residues can drastically modulate the glycoprotein adsorption strength on surfaces 2/2 #compchem #compchemsky #glycotime

📣 Check out our 𝔾𝕝𝕪𝕔𝕠-𝕒𝕕𝕤𝕠𝕣𝕡𝕥𝕚𝕠𝕟 on 𝔽𝕠𝕞𝕚𝕥𝕖𝕤
Preprint! doi.org/10.1101/2025... We highlight glycans’ dual capacity, to act either as a glue that dominates the whole glycoprotein adsorption strength via tethering, or as a blocking element preventing adsorption 1/2 #glycanResearch #glycanAsGlues 🩹🧵🦠

After 4 days of listening to top-notch experts in the field of glycoprotein/membrane interactions. I want to say big thanks to @rommieamaro.bsky.social @biophysmatt.bsky.social @rocovino.bsky.social and AtilioV & @giorgiocolombo.bsky.social for hosting me as a speaker and also poster presenter* 2!

awesome, and very helpful to the computational biophysist!🧶🪡

Participate in Capri, BTW are glycan-protein complexes also tackled?

Congrats, sounds like a very challenging question! I've bookmarked the Preprint! Could you share some trajectories 💾👍?

Same question here!