Lydia Finley

Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation and citrate production increa...

#NatMetabPicks | In @cp-cell.bsky.social led by @lydiafinley.bsky.social ( @mskcancercenter.bsky.social ) 🧪

Citrate clearance is an essential function of the TCA cycle via the activity of aconitase 2.

www.cell.com/cell/fulltex...

Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation and citrate production increase, aconitase 2 becomes essential to prevent mitochondrial citrate accumulation, which can trigger the integrated stress response and impair cell fitness.

Now online! Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle

I agree with this 💯 -- amazing to see how this project came together from two different angles and took off once Julia and Abby really teamed up. Collaboration at its best!

Congrats (again) to Julia and Abby for their collaborative effort asking when and why cells use the TCA cycle. TLDR; it's not just about ATP or making nutrients-- the TCA cycle is also important to remove nutrients!

HUGE congratulations to our very own Julia Brunner for her paper describing cell-state dependent engagement of the malate-aspartate shuttle, out today!! Many thanks to all lab members, funders, and colleagues who supported the work, and stay tuned for more from Julia very soon!

We are hiring a postdoc! The group has a funded opening to join our amazing team on the NCI's Frederick, MD campus.

This is an opportunity to train in cutting-edge chemical & RNA biology methods with a supportive, tight-knit group.

Link to posting below. Please share!

jobrxiv.org/job/national...

📣 First preprint from the TeSlaa lab 📣 We investigated how methyl-rich nutrient, choline, is used in the body and how systemic one-carbon metabolism responds to dietary methyl-donor deficiency.
www.biorxiv.org/content/10.6...

A p53-controlled lysosomal recycling circuit fuels phospholipid synthesis - Nature Cell Biology The transcription factor p53 enables phosphoethanolamine scavenging to support increased membrane phospholipid synthesis during senescence. Perturbing lipid synthesis or recycling compromises the fitn...

🍰Read also the Research Briefing here:
👉https://rdcu.be/e3tiZ
bit.ly/404rclA

p53 increases phospholipid headgroup scavenging in senescence - Nature Cell Biology Yashinskie, Zhu and colleagues show that p53 activation triggers increased synthesis and accumulation of phospholipids, with enhanced activation of autophagy and lysosomal catabolism programmes and in...

☕Yashinskie, Zhu et al show that #p53 activation triggers increased synthesis and accumulation of phospholipids, with enhanced activation of #autophagy and lysosomal catabolism programmes and increased reliance on lipid headgroup recycling. @lydiafinley.bsky.social
bit.ly/4asbwO3

Lab’s 1st preprint!

Menstruation is understudied due to societal taboos + a biological challenge: mice (a key system for research + drug discovery) don’t menstruate.

@cagricevrim.bsky.social made menstruating mice + used them to discover early events in menstruation.

He is on the job market!

Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...

Just out in @science.org: Together with the lab of @johanneszuber.bsky.social, we used sequential in-vitro/in-vivo screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...

Check out the symposium organized by our CoE, excited to have Marcia Haigis, @lydiafinley.bsky.social, Matthias Hebrok and Tom MacVicar over in Helsinki in November. Sign up by October 22nd 👇

Human iPSC derived alveolar macrophages reveal macrophage subtype specific functions of itaconate in M. tuberculosis host defense M. tuberculosis must survive within multiple macrophage populations during infection, including alveolar macrophages (AM) and recruited inflammatory macrophages. In mice, itaconate, produced in macrop...

Happy to share the most recent preprint from the lab, the thesis work of Dr. Adam Krebs and a collaboration with many, including the Geissmann lab @mskcancercenter.bsky.social
Here is a short paper thread. #tuberculosis #macrophages 🦠
www.biorxiv.org/content/10.1...

Super excited to share new review on metabolic stress and adaptations in pancreatic cancer to these stresses from @cssheehan.bsky.social
jci.org/articles/vie... 1/6

Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells - Nature Metabolism Andersson et al. show that intestinal stem cells enriched for old mitochondria are metabolically distinct and have enhanced ability to regenerate the epithelial niche.

Proudly presenting Simon’s @simonsterson.bsky.social‬ paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Paneth cell linage through aKG-dependent metabolism
@naturemetabolism.bsky.social www.nature.com/articles/s42... @helsinki.fi @metastem.bsky.social 🧵1/8

Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma Mitochondrial Ca2+ signaling regulates branched-chain amino acid catabolism in an adolescent liver cancer.

Our paper on regulation of BCAA catabolism by mitochondrial calcium signaling is out!
Mitochondrial calcium signaling regulates branched-chain amino acid catabolism in fibrolamellar carcinoma | Science Advances www.science.org/doi/10.1126/...

Intracellular metabolic gradients dictate dependence on exogenous pyruvate Nature Metabolism, Published online: 28 April 2025; doi:10.1038/s42255-025-01289-8Jackson et al. provide insight into how metabolic adaptations that accompany cell state transitions drive reliance on exogenous nutrient availability, focusing on pyruvate as a key metabolite in central carbon metabolism.

ICYMI:

Thank you Christian!

Intracellular metabolic gradients dictate dependence on exogenous pyruvate Nature Metabolism - Jackson et al. provide insight into how metabolic adaptations that accompany cell state transitions drive reliance on exogenous nutrient availability, focusing on pyruvate as a...

I'm excited to share our latest story from the
@lydiafinley.bsky.social lab, where we show that it's not just whether cells take up nutrients that matters, but how and where those metabolites are used. Out now in @naturemetabolism.bsky.social: rdcu.be/ejFTs 1/

Glucose-6-phosphate-dehydrogenase on old peroxisomes maintains self-renewal of epithelial stem cells after asymmetric cell division - Nature Communications Peroxisomes are essential but their role in cell fate regulation remains understudied. Here, the authors reveal that young and old peroxisomes are not equally distributed in asymmetrically dividing st...

Happy to present Hien’s paper on age-selective apportioning of peroxisomes as a fate determinant in adult stem cells www.nature.com/articles/s41... @metastem.bsky.social @helsinki.fi @ki.se @helsinki-biotech.bsky.social out now in @natcomms.nature.com
A thread 🧵 1/9

Showcase your research! Submit your poster abstract by April 16 (11:59pm MST) to join speakers @lydiafinley.bsky.social, Ralph J. DeBeradinis, & Keynote Navdeep Chandel. Apply now: keysym.us/KSMetabDev25. Can't attend? Access insights On Demand for 6 months post-conference!

#KSMetabDev25 #cellfate

Cancer Metabolism and Signaling in the Tumor Microenvironment - NYAS April 8, 2025 | 9:00 AM – 5:00 PM ET Join leading experts at the forefront of cancer metabolism research for a one-day event on April 8, 2025, in New York City. The New York Academy of Sciences invite...

2 weeks to go to the annual NYAS cancer metabolism symposium, April 8 at NYU Langone!

www.nyas.org/shaping-scie...

Register now using code CancerMetabolism10 for a 10% discount. And hurry! Last year we sold out!

cc: @lyssiotislab.bsky.social @marcusgon.bsky.social

How Metabolism Can Shape Cells’ Destinies | Quanta Magazine A growing body of work suggests that cell metabolism — the chemical reactions that provide energy and building materials — plays a vital, overlooked role in the first steps of life.

www.quantamagazine.org/how-metaboli...
Seems like a good time to remind you of an upcoming meeting on this exact topic:
www.keystonesymposia.org/conferences/...

We are 2 weeks out from the @NYASciences Cancer Metabolism meeting - still time to register! Join us for:

Exciting science ✅
Awesome speakers ✅
Great camaraderie ✅
Science jokes⚠️
Celebrity appearances‼️ (probably not)

Please circulate 🔁

events.nyas.org/event/16a78a...

KSQA: Dr. Lydia Finley (Metabolic and Nutritional Control) YouTube video by KeystoneSymposia

Unlock $200 in savings on Metabolic and Nutritional Control by registering before 11:59 PM MST on March 20! Don't miss the chance to hear from @lydiafinley.bsky.social this May in Beverly, MA, USA. Secure your spot now: keysym.us/KSMetabDev25.

#KSMetabDev25 #metabolism youtu.be/le7D7qpo4sM

Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair Genetic screen finds lipoylation as a target to improve radiation success in lung cancer by blocking DNA damage repair.

1/Happy to share a new paper reporting a metabolic approach to radiosensitization in lung cancer, from Rachel Chiang, Faith Zhang and colleagues at UT Southwestern Radiation Oncology and @cri-utsw.bsky.social
www.science.org/doi/10.1126/...

A potent and selective TNKS2 inhibitor for tumor-selective WNT suppression Hyperactive WNT signaling is a potent cancer driver, but clinical translation of WNT inhibitors has been hampered on-target toxicities. WNT signaling can be constrained through inhibition of the PARP ...

New preprint time!!

This one has been brewing in the lab for ~8 years describes a strategy for tumor selective WNT suppression. It was led by an amazing (then) grad student, Jill Zimmerman, with help from a host of lab members and collaborators along the way.

www.biorxiv.org/content/10.1...

Metabolic and Nutritional Control Meeting Promo YouTube video by KeystoneSymposia

Metabolic & Nutritional Control of Development and Cell Fate is just around the corner. Register by March 20 (11:59pm MST) and snag a $200 discount! Don't miss our incredible speaker lineup! 👉 keysym.us/KSMetabDev25.

#KSMetabDev25 youtu.be/CSto4rJv40I
@lydiafinley.bsky.social @rjdlab.bsky.social

Congratulations @hitelabmskcc.bsky.social and @dirkremus.bsky.social et al!