Laszlo Dobson

Linear motifs regulating protein secretion, sorting and autophagy in Leishmania parasites are diverged with respect to their host equivalents Author summary Leishmaniasis is a detrimental disease which causes significant decrease in quality of life and in severe cases can be lethal. The disease is caused by the pathogen Leishmania spread by...

Our paper about #Leishmania linear motifs is out! We describe three protein sorting systems critical for Leishmania, that are greatly diverged from their host counterparts: secretory signal peptides, ER retention motifs, and autophagy signals.
doi.org/10.1371/jour...

Deep learning driven de novo drug design based on gastric proton pump structures Communications Biology 6, 956 www.nature.com/articles/s42... Now in PDBTM: pdbtm.unitmp.org/entry/8ijv