Sam Morabito

Thanks for sharing and glad you found it interesting 😀 Working on a 🧵 to share some of the main highlights in the next couple of days

A new comparative single-cell multi-omic study of two neurodegenerative disorders, Alzheimer's disease and Pick's disease.

A long time in the making and finally published last week!! 🥳

TooManyCells identifies and visualizes relationships of single-cell clades - Nature Methods The TooManyCells approach to scRNA-seq data facilitates efficient and unbiased identification and visualization of cell clades and rare subpopulations. Application of TooManyCells to drug-resistant le...

Reminds me of this tool TooManyCells

www.nature.com/articles/s41...

🗞️ Genetic diversity has a profound impact on genomic annotations, and there is currently a massive European bias in widespread annotations like GRCh38 🤯

This paper is the result of the hard work and passion of @pclavell.bsky.social and @fairlie.bsky.social, congrats to the authors!

Long-read transcriptomics of a diverse human cohort reveals widespread ancestry bias in gene annotation https://www.biorxiv.org/content/10.1101/2025.03.14.643250v1

I got laid off today, with the rest of 18F.

18F was an elite federal software shop. We made gov't websites work better, more efficiently for the American people. We saved taxpayers from getting screwed over by contractors. And were fired for it.

We made this website to tell our story:
18f.org

“Assume that what you write will be read by malign foreign actors and tailor your response accordingly.”

Grad Admission Impacts Survey It is grad admissions season and many postbacs are feeling the chilling impacts of the Trump administration's recent executive orders freezing and slashing extramural research funding. Dozens of gradu...

As a result of Trump’s slashes to research funding, dozens of graduate programs have announced reductions and cancellations of graduate admissions slots.

If you are an impacted applicant, please fill out this survey: docs.google.com/forms/d/e/1F...

🧪🧠🧬🔬🥼👩🏼‍🔬🧑‍🔬

a blue sky with a butterfly and the word bluesky on it ALT: a blue sky with a butterfly and the word bluesky on it

🌟Great News: CNAG is now on BlueSky!
🚀From Barcelona to the world, we’re bringing you the latest in genomics!

Stay tuned for breaking news, cutting-edge technologies, groundbreaking research, and upcoming events

🔗https://www.cnag.eu
#Genomics #Innovation #Research #BlueSky #CNAG

Thank you for submitting your Letter of Intent (LOI) to CZI. We appreciate your interest in our work. CZI has decided not to continue with the second round of its Science Diversity Leadership Awards. We are committed to supporting groundbreaking research that advances the frontiers of scientific knowledge in pursuit of our mission to cure, prevent, or manage all diseases by the end of the century. We will provide information on future funding opportunities. We look forward to staying in touch. Bil Clemons, Program Officer, CZI

Pretty sad. Just got the email that CZI is canceling the second round of Diversity Leadership Awards. Private industry will definitely not fill the hole that NIH and NSF are leaving. 😢💔

I was just told that I have to remove “climate” from the title of an ongoing grant if I want to keep it. And publications from that grant cannot include “climate” and other forbidden words. I can’t believe I’m writing this from the United States of America. #AcademicSky

NIH slashes overhead payments for research, sparking outrage Move to cut indirect cost rate to 15% could cost universities billions of dollars

The National Institutes of Health plans to severely cut the percentage of its grant money that can be used for overhead costs rather than research.

1. Today the NIH director issued a new directive slashing overhead rates to 15%.

I want to provide some context on what that means and why it matters.

grants.nih.gov/grants/guide...

This seems like an interesting tool to empower biomedical research 💪

However, it does not seem like this manuscript has a Methods section, or information about the peer review, even though the paper discusses "transparency standards required for reproducible research". Am I missing something?

Inspired by @charlesgaba.com's Herculean effort to post all Wayback URLs from the CDC website (including pages that have recently been deleted), I built this GitHub repo to share Wayback links to all CDC website pages, and will add more websites when I get a chance github.com/Niema-Lab/Go...

📢 SUPER EXCITED to share our latest preprint:
Decoding the immune response in leptomeningeal disease through single-cell sequencing of cerebrospinal fluid

Incredible work and collaboration from @jcnietos.bsky.social @piazeiner.bsky.social @hoheyn.bsky.social and others.
biorxiv.org/content/10.110…

Added 😊

All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.

Very grateful 🙏 for all who helped throughout the process, my current advisor Holger Heyn, my PhD advisor Vivek Swarup, all of my labmates in the #SingleCell #Genomics team at CNAG.

This year I wrote 5 applications for postdoc fellowships, most of which were rejected ☠️ so this feels like an early xmas present and some much needed encouragement to hit the ground running 🏃‍♂️ in 2025 💪

Overjoyed to share that I was selected for the EMBO #postdoc fellowship for my proposal titled "Charting immune cell signatures to tackle non-response to immunotherapy in colorectal cancer". Excited to work on this project over the next few years in #Barcelona!

#EMBOFellows

3 reviews on planning, execution, & validation of transcriptomic experiments in neuroscience published in @natureportfolio.bsky.social #NatureNeuroscience.
A MUST READ if you're doing transcriptomics.
3 reviews, an amazing editorial, a beautiful cover – this is the issue of the year!
(mini thread)

Predicting gene expression from histone marks using chromatin deep learning models depends on histone mark function, regulatory distance and cellular states Abstract. To understand the complex relationship between histone mark activity and gene expression, recent advances have used in silico predictions based o

So excited that our work on predicting gene expression from histone modifications using deep learning is out in NAR today. Brilliant to work with lead author @al-murphy.bsky.social and collaborators Aydan Askarova, @borislenhard.bsky.social and Nathan Skene 🧬⭐️🙏
academic.oup.com/nar/advance-...

Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer’s disease - Nature Genetics Spatial and single-nucleus analyses in human postmortem Alzheimer’s disease (AD) brain tissues at early and late stages from individuals with and without Down syndrome, as well as in AD mouse models, ...

Link to the full paper:

www.nature.com/articles/s41...

A really nice summary on Alzforum of my recent paper where we used #SingleCell and #spatial #omics to investigate molecular and cellular abnormalities in the brains of individuals with Alzheimer's in Down Syndrome (DSAD).

www.alzforum.org/news/researc...

Big day for single cell and neuroscience. Trio of single cell perspective pieces discussing applications, opportunities, challenges, and validation of single cell and spatial genomics in neuroscience are out now in Nature Neuroscience. Links in thread below.👇 1/n

A little piece that's been in the works with former MSc, now PhD student, Jiayi Wang & @markrobinsonca.bsky.social in the multi-sample/-condition/-subpopulation theme: ...

Hi all! I'm a computational biologist studying the impact of variation on the functional genome at @bsc-cns.bsky.social. Consortium alumnus (ENCODE, LRGASP, IGVF @igvfconsortium.bsky.social); @ucirvine.bsky.social PhD; @ucsandiego.bsky.social BS; and recent transplant from California to Barcelona.

Spatial mapping of Alzheimer’s disease across genetic subtypes - Nature Genetics Alzheimer’s disease is a complex, heterogeneous disorder with multiple genetic subtypes. Spatial and single-cell gene expression analyses of these subtypes have provided new insights into general and ...

News & Views with @irholtman.bsky.social on spatial and single-cell gene expression analyses of Alzheimer's and Down's Sydrome www.nature.com/articles/s41.... This is a commentary on the work by the Swarup lab: www.nature.com/articles/s41....

Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer’s disease - Nature Genetics Spatial and single-nucleus analyses in human postmortem Alzheimer’s disease (AD) brain tissues at early and late stages from individuals with and without Down syndrome, as well as in AD mouse models, ...

Our comparative spatial & single-nuc study of Alzheimer's, Down Syndrome in AD, and a genetic mouse model, just published in Nature Genetics. Massive effort of the 2nd half of my PhD, and a pleasure to work with co-first author Emily, my advisor Vivek, & many others at UC Irvine 🧠 🧬