Thrilled to wrap up the year and my postdoc work in the Nester lab with this publication 🥳! We show that astrocytic CREB regulates astrocyte calcium and D1-MSN activity to drive behavioral response to cocaine. pubmed.ncbi.nlm.nih.gov/41406210/
Repair after CNS injury is not strictly local!
We find that lesion-remote #astrocytes (LRAs) exhibit striking spatiotemporal heterogeneity across spared regions of the injured spinal cord and shape neural repair far from the injury epicenter!
www.nature.com/articles/s41...
Really excited to announce that the Holt lab will be starting in January 2026 in the Center for Substance Use Research at Temple University Lewis Katz School of Medicine. Interested in the role of gene regulation, astrocytes, and addiction? I'm hiring at all positions-DM or email me! l-holt-lab.com
We characterized the NAc astrocyte transcriptome following cocaine self-administration and implicate astrocytic CREB as a cocaine-induced transcription factor in astrocytes that regulates astrocytic calcium, D1-MSN neuronal activity, and the behavioral response to cocaine
Excited to share the preprint for one of my postdoctoral projects in the Nestler lab 🥳
