Dan Auclair

PRDM1 shapes germinal center B-cell clonal diversity by gating chromatin accessibility during light-to-dark zone transition @biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...

#IMS25 full abstracts are out! #myelomasky #hemesky

For breaking news and expert analysis during #ASCO25, turn to #ASCODailyNews! During and after the Meeting, ASCO Daily News has coverage of all the practice-changing research being presented. Bookmark us now: dailynews.ascopubs.org/meetings/asc... #oncsky

Nexicart-2 in AL amyloidosis
meetings.asco.org/abstracts-pr...

Next-gen HealthTree Cure Hub
meetings.asco.org/abstracts-pr...

And many more great ones. Congrats to everyone and looking forward to seeing you this week at the meeting.

LINVO + CFZ, LINKER-MM2 trial
meetings.asco.org/abstracts-pr...

ISB 2001
meetings.asco.org/abstracts-pr...

Elranatanab + Dara MagnetisMM-6 part 1
meetings.asco.org/abstracts-pr...

JNJ-5322 trispecific
meetings.asco.org/abstracts-pr...

Now that the final #ASCO25 abstracts are out, here are my top #myelomasky ones

Etentamig
meetings.asco.org/abstracts-pr...

IberVd
meetings.asco.org/abstracts-pr...

5-Year Follow-up on CARTITUDE-1

meetings.asco.org/abstracts-pr...

The US has world-class scientific talent. The rest of the world is hoping to lure that away As the Trump administration cut billions of dollars in federal funding to scientific research, thousands of scientists in the U.S. lost their jobs or grants — and governments and universities around t...

The US has world-class scientific talent. The rest of the world is hoping to lure that away

www.yahoo.com/news/us-worl...

Roche taps Broad Institute to test SBX sequencing in the clinic Roche raised the curtain on its novel approach to DNA sequencing earlier this year, and now it's working with the Broad Institute to explore its use cases, ahead of a full public launch s | Roche tapp...

Roche taps Broad Institute to test SBX sequencing in the clinic

www.fiercebiotech.com/medtech/roch...

An ultrasensitive method for detection of cell-free RNA - Nature A method, RARE-seq, for sensitive detection of cell-free RNAs in blood is demonstrated to have diverse clinical applications including diagnosing and characterizing human cancers, and tracking respons...

An ultrasensitive method gor detection of cell-free RNA

www.nature.com/articles/s41...

US reviewing federal contracts, grants to Harvard over antisemitism allegations The administration of Republican President Donald Trump announced a review on Monday of federal contracts and grants at Harvard University over allegations of antisemitism.

Challenging times.

Harvard at risk of losing $9 billion in federal funds as US launches review

www.reuters.com/world/us/us-...

Cell Press banner that reads "50 Scientists that Inspire: Putting a spotlight on researchers who drive innovation" The headshots of Drs. Madhukar Pai, Johanna Joyce, Juan-Pablo Correa-Baena, & Hanna Kokko are illuminated under a spotlight.

Check out our #50ScientistsThatInspire interviews with Drs. Madhukar Pai, Johanna Joyce, Juan-Pablo Correa-Baena, & Hanna Kokko threaded below🧵

@madhupai.bsky.social @johannajoyce.bsky.social @jpcorreabaena.bsky.social @kokkonut.bsky.social

Quite an essay on the basis of cancer entitled "The End of the Genetic Paradigm of Cancer" @plosbiology.org arguing against the primacy of somatic mutations (traditional model) and cells, invoking gene regulatory networks and tissue
journals.plos.org/plosbiology/...

BCMA-directed CAR T-cell therapy in patients with multiple myeloma and CNS involvement ⁦‪⁦‪#MyelomaSky

ashpublications.org/bloodadvance...

Advantages of a NGS assay for detection of mutant NPM1 MRD in AML #HemeSky

- Detection of mNPM1 MRD by NGS overcomes several limitations of RT-qPCR

- Prognostic significance of mNPM1 MRD appears greatest in patients with AML with a concomitant FLT3-ITD

ashpublications.org/bloodadvance...

Large-scale dependency and drug screens characterize the therapeutic vulnerabilities of Multiple Myeloma with 1q+ @ireneghobrial.bsky.social #MyelomaSky

ashpublications.org/blood/articl...

Hallmarks of artificial intelligence contributions to precision oncology - Nature Cancer Ruppin and colleagues overview recent research on the use of AI frameworks in precision oncology, describe ten hallmarks of their contributions across cancer detection, therapy optimization and treatm...

Nice review: Hallmarks of AI contributions to precision oncology

www.nature.com/articles/s43...

Trump's FDA Cuts Are Putting Drug Development at Risk New SEC filings from pharmaceutical companies reveal Donald Trump and Elon Musk's cost-cutting measures could slow drug research and delay FDA approvals.

New SEC filings reveal potential further impact of federal cuts

www.wired.com/story/trump-...

Dissecting tumor cell programs through group biology estimation in clinical single-cell transcriptomics - Nature Communications Existing methods for identifying differential gene expression signatures for clinical case/control analyses with high throughput sequencing data present various challenges. Here, the authors develop B...

Dissecting tumor cell programs through biology estimation in clinic single-cell transcriptomics
www.nature.com/articles/s41...

Legendary former NIH director retires from embattled agency Dr. Francis Collins is leaving the National Institutes of Health, where he served as director from 2009 to 2021. The agency is facing cutbacks and restrictions under the Trump administration.

Francis Collins retires from NIH

www.npr.org/sections/sho...

Come together, right now The chaos, conflicting information, firings, and hurtful rhetoric of the Trump administration’s approach to science over the past month are causing anxiety, grief, and concern for the scientific commu...

Coming together for sciences

www.science.org/doi/10.1126/...

Lung-MAP 3.0: Simplifying the Process to Meet Patients’ Needs The Lung Cancer Master Protocol (Lung-MAP) is an innovative clinical trial designed to efficiently address the unmet needs of patients with advanced non–small cell lung cancer (NSCLC) following front-...

Lung-MAP 3.0. Adding NGS screening options for patient recruitment

ascopost.com/issues/febru...

Trends in Physician Electronic Health Record Time and Message Volume This cohort study uses national electronic health record data to assess patient medical advice request message volume and the time physicians spend in the records.

The time relegated to being data clerks among US physicians is increasing
jamanetwork.com/journals/jam...

The University of Pittsburgh pauses its Ph.D. admissions process amid research funding uncertainty A spokesperson for the University told WESA Friday that the school has "temporarily paused additional Ph.D. offers of admission," while Pitt works to understand how proposed federal funding cuts could...

Pitt to pause PhD admissions, following Vanderbilt and USC, because of uncertainty of NIH funding to academic universities.

Who will teach and train US scientists for pharma and biotech? Should we import them from countries that do?

www.wesa.fm/health-scien...

One of many similar stories to come out in the last week. A sad state of affairs.

FDA Reels From ‘Indiscriminate’ Job Cuts Under Trump as Biopharma Appeals for Clarity Morale is low at the FDA, which was hit with layoffs this week following RFK Jr.’s confirmation. Biopharma leaders and agency insiders fear further workforce cuts could delay new medicines.

Turmoil at FDA and fears it might impact new drug approvals

www.biospace.com/fda/fda-reel...

Illumina unveils first-of-its-kind spatial transcriptomics technology

Illumina unveils its novel spatial transcriptomics platform

www.illumina.com/company/news...

Trump’s siege of science: how the first 30 days unfolded and what’s next The breakneck pace and devastating impact of the administration’s policy changes has researchers shocked.

US researchers are in shock. What to expect next.

www.nature.com/articles/d41...

Genetic disruption of Blimp-1 drastically augments the antitumor efficacy of BCMA-targeting CAR T cells Key PointsAblation of Blimp-1 in anti-BCMA CAR T cells improves efficacy, representing a promising novel therapeutic product for MM.Transcriptomic analysis

Genetic disruption of Blimp-1 drastically augments the antitumor efficacy of BCMA-targeting CAR T cells #MyelomaSky

ashpublications.org/bloodadvance...

NIH reportedly loses two top leaders in two days Two key staff members at the National Institutes of Health (NIH) are reportedly leaving the agency amid ongoing efforts by the Trump administration and Department of Government Efficiency head Elon…

NIH reportedly loses two top leaders in two days

www.qcnews.com/nexstar-medi...

Congrats, and happy to see your labor of love coming to fruitions Jonathan @pedalheadphx.bsky.social #MyelomaSky