Bryan Duoto

Awesome. Love to see it. It makes you a great architect, entrepreneur, and systematic problem solver.

For me it started with immunology, branched out to stem cell bio, then chemical engineering, biochemistry, and finally AI

I've always struggled with understanding other scientists who only like their specialization and little else.

Do other people like to be "generalists" or "generalist-specialists?" What are your sub-specialities and other insterests?

The Phylogeography of Potato Virus X Shows the Fingerprints of Its Human Vector Potato virus X (PVX) occurs worldwide and causes an important potato disease. Complete PVX genomes were obtained from 326 new isolates from Peru, which is within the potato crop′s main domestication c...

It's likely that it was also transported to Europe after the 15th century. Check out one of the papers here 2/2

pmc.ncbi.nlm.nih.gov/articles/PMC...

@neuronick.bsky.social had a great post on how potatoes were the first GMO tech, which helped the Incan empire flourish.

Their domestication also coincided with Potato Virus X, the subject of my thesis. It coemerged with the domestication of the potato 9,000 years ago 1/2.

Anyone have those days where you wake up and are baffled by some of the weirdness in biology?

Like how most viruses have converged into just a few shapes over millions of years but some of these weirdos out here looking like candy corn?

Rabies is definitely the scariest candy corn. 🌽

We are still figuring it out! What we do know is that shape triggers different immune pathways.

Ex: spherical triggers TH1 pathway and rod-shaped triggers TH2

We've also seen that certain shapes penetrate solid tumors. We've cured several pet dogs with icosahedrons and B cells love filaments!

The shape of a particle determines how the immune system interacts with it. Elongated or high aspect ratio shapes elicit a stronger inflammatory response compared to spherical particles of similar size.

You can basically control how matter is taken up by cells and shown as an antigen, by shape!

I used to live in Sonoma County -- I highly recommend it 👌

Hey Bluesky, what's up? I'm Bryan and my background is a combo of Bio, AI, and NanoEngineering. I'm an epiphany junkie, a tool builder, and a relentlessly curious life scientist.