Paul Sauer

January 29, 2025 M-25-14 MEMORANDUM FOR HEADS OF EXECUTIVE DEPARTMENTS AND AGENCIES FROM: Matthew J. Vaeth, Acting Director, Office of Management and Budget Me SUBJECT: Rescission of M-25-13 OMB Memorandum M-25-13 is rescinded. If you have questions about implementing the President's Executive Orders, please contact your agency General Counsel.

🚨 BREAKING: OMB has just issued a memo *rescinding* the previous memo freezing all federal financial assistance programs.

Full text, per government source:

Our first paper here at #interdictbio!

As someone who grew up in Austria I am really concerned about the apparent lack of concern. y'all should distribute the small book 'Biedermann und die Brandstifter' by Max Frisch ("The Fire Raisers: A Morality Without a Moral,"), which lays it out in detail. 🧵

"On a molecular level, our structural studies reveal that interdictors bind in a linkerless heterobifunctional manner to both the rRNA and the nascent peptide chain ... much the way a PROTAC can be modularly designed and constructed"

Context-dependent translation inhibition as a novel oncology therapeutic modality Inhibitors of protein synthesis, including anisomycin, homoharringtonine, and other natural products bind in the peptidyl-transferase center (PTC) of the eukaryotic ribosome to inhibit translation. Re...

Is RNA translation the next hot area in #cancer therapeutics?

Take a look and make a decision for yourself!

#RNAsky
#ONCSky
🧬 💻
#genomics

www.biorxiv.org/content/10.1...

Congratulations @trinitycookis.bsky.social for a great paper! Biochemical and structural disscection of PRC2 activation and inhibition by modified histones!