New in the press!
Mojica-Sánchez et al. explore metal-doped graphene for glyphosate removal using DFT and molecular dynamics. Fe³⁺- and Al³⁺-doped graphene show the strongest adsorption, highlighting promising nanomaterials for environmental remediation. #AusJChem
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(4/4)
Access the review article here: connectsci.au/ch/article/7...
This article is part of the 70th Birthday tribute to Professor David Craik. The collection can be accessed here: connectsci.au/ch/collectio...
Linked in: www.linkedin.com/in/laszlo-ot...
semmelweis.hu/mikrobiologi...
(3/4) Laszlo Otvos added when reached for comment about his field of study:
Too many of my mentors, friends and relatives suffered and passed away from diseases that are potentially curable with biological drug treatments
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(2/4) This review by Laszlo Otvos covers the various modes of action of these antimicrobial peptides and explores their potential as antiviral chemotherapy agents.
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(1/4) Classical antimicrobial peptides (AMPs) have been demonstrated to kill bacteria in vitro. In the past few years there has been interest in studying their antiviral properties.
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This article forms part of the 70th Birthday Tribute to Professor David Craik. @csiropublishing.bsky.social #AusJChem
You can find this collection here:
connectsci.au/ch/collectio...
A recent study by Daly et al. reveals that the C-terminal region of Opisthorchis viverrini granulin-1, despite lacking regular structure, still drives strong fibroblast growth, highlighting surprising bioactivity and potential as a wound-healing agent. #AusJChem
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(4/4) Article: connectsci.au/ch/article/7...
This article is part of the 70th Birthday tribute to Professor David Craik which can be access here:
connectsci.au/ch/collectio...
Linkdn: Octavio Franco, Instagran: @francocientista
Universidade Catolica Dom Bosco/Universidade Catolica de Brasilia
(3/4) These advancements being led primarily by computational tools and AI to improve their stability and selectivity and effectiveness through by determining optimal amino acid sequencing.
Correspondence author Octavio Luiz Franco added:
“I basically love peptides.”
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(2/4) Macrocyclic peptides (MCPs) are one such alternative. Their structure allows them great potential in acting against pathogens. In this review Samilla B. Rezende & al present the work that has been done to improve the effectiveness of MCPs for pathogen treatment.
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(1/4 Antimicrobial resistance (AMR) is a growing concern when it comes to effective therapeutics. As such a great deal of work has been done to find alternatives treatments which can circumvent AMR.
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This article is part of the 70th Birthday tribute to Professor David Craik. #AusJChem @csiropublishing.bsky.social
The collection can be accessed here:
connectsci.au/collection/2...
Conibear et al. have published exciting new work uncovering how post-translational modifications shape the stability and activity of µ-conotoxins. A great step forward for peptide chemistry and ion-channel research. #AusJChem @csiropublishing.bsky.social
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(5/5) This article is part of the 70th Birthday tribute to Professor David Craik. The collection can be accessed here: connectsci.au/ch/collectio...
@jayanigamage.bsky.social @paccardenas.bsky.social @vetenskapsradet.bsky.social
(4/5) "Additionally, understanding the ecological role of these peptides will advance our understanding of their natural functions but also guide the sustainable exploration of their potential therapeutic applications”
Access the research article here: connectsci.au/ch/article/7...
(3/5) "We believe they hold significant pharmaceutical potential, both for their largely unexplored inherent bioactivities and as valuable molecular scaffolds for drug discovery."
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(2/5) Correspondance author Sunithi Gunasekera commented:
“Ribosomally synthesized and posttranslationally modified peptides found in marine sponges, especially the ones produced by the host sponges themselves are an understudied group of natural products."
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(1/5) Lakmini K. & co presents a review of the research done studying the ribosomal peptides found in marine sponges and associated microsymbionts in order to elucidate what has been done and highlight the need for expanded research in this high potential field.
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Poulsen et al report native mass spectrometry (nMS) as a powerful platform for electrophilic covalent fragment screening. A robust, target-agnostic approach advancing covalent probe discovery and drug development.
From Prof David Craik's tribute collections.
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(5/5) Access the research article here: doi.org/10.1071/CH25117
This article is part of the 70th Birthday tribute to Professor David Craik. The collection can be accessed here:
lnkd.in/g3RbukpG
#pforzheimuniversity #techpf #AusJChem
(4/5) “Interdisciplinary research pushes boundaries, sparks curiosity, makes discoveries exciting, sometimes raises more questions than it answers, and generally generates innovative solutions by integrating different perspectives" says Ute C. Marx, corresponding author.
(3/5) Despite the technique’s challenges such as low sensitivity and overlapping signals, NMR remains a powerful tool for assessing media composition, freshness and metabolic state in biological research.
(2/5) This work by Marx and Oey uses NMR spectroscopy to reveal both expected and hidden components in complex mixtures such as cell culture media, uncovering ethanol contamination, glutamine degradation and lactate from added serum.
(1/5) NMR spectroscopy for mixture analysis – both a blessing and a curse: dissecting cell growth media as an example
New research in #AusJChem!
Lee et al show that zwitterionic cyclopentadienyl ligands can stabilise low-valent Rh(I)/Ir(I) complexes, revealing powerful redox behaviour and hyperpolarisation capability. A smart step forward for advanced catalysis. #AusJChem
Details: connectsci.au/ch/article/d...
A. Garget & Co. present a review of the development of boronic acid-based fluorophores for application in sensing sialic acids. Sialic acid are a family of carbohydrates found in the surface of cells which can be used as biomarkers of various diseases.
Details:
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Rodger et al. explain the origin of vibrational linear dichroism (VLD) artefacts in transmission and attenuated total reflectance (ATR), improving how polarised IR data are interpreted for clearer structural insight. #AusJChem @csiropublishing.bsky.social
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Aguilar et al unveil an AFM-based approach to study how β-peptide hydrogels interact with cell membranes. Using β-peptide fibres to support lipid bilayers (SLBs), they reveal nanoscale membrane behaviour, paving the way for smarter biomaterials. #AusJChem #openaccess
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Tianhui Wang & al. present the first synthesis method for ferrate(VI) (FeO42−) in acidic conditions. This is a more effective and greener method when compared to the typical alkaline synthesis method which can prove destructive and pollutive.
#AusJChem
Details: connectsci.au/ch/article/7...
Hasi Rani Barai & al. present an optimised synthesis for butyl methyl chlorophosphite. They then investigated the kinetics of the compounds reaction with X-pyridines in order to propose a concerted mechanism for the nucleophilic substitution
#AusJChem
Details: connectsci.au/ch/article/7...
