Sonja Blasche

Interspecies interactions drive bacterial proteome reorganisation and emergent metabolism Species in microbial communities must respond to the presence of others to stave off resource competition or to capitalise on new resources that may become available due to additional metabolic activi...

Check out our new preprint!
We systematically map proteomic and metabolomic interactions between >100 pairs of gut bacteria, detecting metabolic interactions and functionally-related clusters of proteins.

www.biorxiv.org/content/10.1...

@kiranrpatil.bsky.social

Join us at CafeSynthetique on 2 June with talks from Wes Roberston @mrclmb.bsky.social 'Synthetic genomics for microbiome reprogramming' and SonjaBlasche
@sonjablasche.bsky.social @mrc-tu.bsky.social 'milk kefir🥛 in fermented food applications' Register here 🦠👉
www.tickettailor.com/events/engin...

Our findings highlight widespread combination effects between commonly co-consumed chemicals in gut bacteria. A collaborative effort with Vinita, @noniberistain.bsky.social @indraroux.bsky.social @skamrad.bsky.social @rbradley.bsky.social @guan06rui.bsky.social @itsbinir.bsky.social and more!(5/5)

Proteomic, metabolomic, and genetic analyses revealed altered small molecule transport underlying this sweetener-drug synergy. This combination also modulated metabolism in a synthetic gut bacterial community, increasing toxicity and altering the secretion of cytokines in human cells. (4/5)

We identified over 100 synergistic and antagonistic growth effects upon co-exposure. For example, isosteviol + duloxetine synergistically inhibited Roseburia intestinalis, a bacterium associated with glucose homeostasis, and Parabacteroides merdae, a prevalent commensal. (3/5)

We tested 39 commercially used sweeteners for their effects on 25 gut-associated bacterial strains. To uncover combinatorial effects, we combined them with four commonly consumed compounds: the sweetener advantame, caffeine, vanillin, and the antidepressant duloxetine. (2/5)

Impact of low-calorie sweeteners on gut bacteria is modulated by common xenobiotics The gut microbiota is implicated in adverse effects associated with low-calorie sweeteners. Yet, the direct impact of sweeteners on gut bacteria remains largely uncharacterized. Here we report interac...

Our latest preprint is on BioRxiv: Impact of low-calorie sweeteners on gut bacteria is modulated by common xenobiotics
www.biorxiv.org/content/10.1... @mrc-tu.bsky.social @kiranrpatil.bsky.social #microsky #microbiomesky (1/5)