Denisa Hathazi

Congrats Jack!

Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...

How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease?

This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility.

www.science.org/doi/10.1126/...

'Skeetorial' of our latest paper: link.springer.com/article/10.1...

So proud of first author Christina Antoniou for this, now a postdoc with @melissa-gammons1.bsky.social.

(1) NMNAT2 is a repressor of SARM1 NADase in axons. A few people have NMNAT2 LoF mutations. Many more have low expression.