Molecular Neurodegeneration

Altered trafficking of Kv1-Kvβ2 leads to neuronal hyperexcitability and memory deficits in amyloid-β pathology - Molecular Neurodegeneration Molecular Neurodegeneration - Potassium channel dysfunction and altered neuronal excitability potentially contribute to cognitive decline in amyloid-β (Aβ) pathology. In particular, the...

Altered trafficking of Kv1-Kvβ2 leads to neuronal hyperexcitability and memory deficits in #amyloid -β pathology

Young-Sin Cho, Seo-Hyun Kim...Yong-Keun Jung #AlzheimersDisease

link.springer.com/article/10.1...

Systems biology of Alzheimer’s Disease: a scoping review of key pathways and mechanisms - Molecular Neurodegeneration Molecular Neurodegeneration - Alzheimer’s Disease (AD) is a progressive and ultimately fatal neurodegenerative disorder, representing the most common form of dementia and affecting nearly...

Systems biology of #AlzheimersDisease: a scoping review of key pathways and mechanisms

Paula J. Bice, Kwangsik Nho, Nilüfer Ertekin-Taner, Andrew J. Saykin

link.springer.com/article/10.1...

Impaired nucleocytoplasmic transport in #SOD1 -mediated #ALS

Shirel Argueti-Ostrovsky, Su Min Lim...Clotilde Lagier-Tourenne @harvardmed.bsky.social @broadinstitute.org & Adrian Israelson @bengurionuniv.bsky.social #amyotrophiclateralsclerosis

link.springer.com/article/10.1...

The functional role of #glial cells in the pathologic brain as reviewed by Alois #Alzheimer in 1910

Helmut Kettenmann, Hans Lassmann, Bilge Ugursu, Xianyuan Xiang #microglia #neuroinflammation

link.springer.com/article/10.1...

Partners in crime – genes ATP13A2 and GBA1 interact to drive neurodegeneration The findings reveal promising biological pathways that could be explored in future therapies.

Why some people with #geneticRisk factors develop #ParkinsonsDisease while others never do? M Gu, H Bellen et al have found an explanation. @bcmhouston.bsky.social @bcmgenetics.bsky.social #TexasChildrens @molneurodegen.bsky.social #BCMPostDoc blogs.bcm.edu/2026/02/12/f...

Targeting tau in #AlzheimersDisease: rationale, approach and challenges

Aram Aslanyan, Martha S. Foiani, Tatiana A. Giovannucci...Ross W. Paterson @ukdri.ac.uk #biomarkers #therapeutics

link.springer.com/article/10.1...

Genetic Duo: ATP13A2 and GBA1 Interactions Fuel Neurodegeneration Parkinson’s disease (PD) ranks as the second most prevalent neurodegenerative disorder following Alzheimer’s disease, impacting more than 10 million individuals globally. The condition manifests thr

Genetic Duo: #ATP13A2 and #GBA1 Interactions Fuel #Neurodegeneration. M. Gu and H Bellen explain their findings. @bcmhouston.bsky.social #TexasChildrens
@molneurodegen.bsky.social @bcmgenetics.bsky.social #BCMPostDoc bioengineer.org/genetic-duo-...

#Lipid alterations in hereditary #peripheralneuropathies: common mechanisms in disease heterogeneity?

Koen Kuipers, Sam Vanherle, Kirsten Poelmans, Esther Wolfs, Jeroen Bogie & Tim Vangansewinkel #neurodegeneration #schwanncells #demyelination

link.springer.com/article/10.1...

It takes two: Genes ATP13A2 and GBA1 interact to drive neurodegeneration Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease, affecting more than 10 million people worldwide. People with this condition may experience tremo...

How do two altered genes, #ATP13A2 and #GBA1, in two different cell types lead to neurodegeneration? M. Gu and H Bellen explain their findings. @bcmhouston.bsky.social #TexasChildrens @molneurodegen.bsky.social @bcmgenetics.bsky.social #BCMPostDoc medicalxpress.com/news/2026-02...

It takes two: #genes ATP13A2 and GBA1 interact to drive #neurodegeneration eurekalert.org/news-release... Mingxue Gu, Jinghan Zhao, Mingxi Deng,
J. Shulman, H. Bellen et al @bcmhouston.bsky.social @#TexasChildrens #Parkinsons @molneurodegen.bsky.social @bcmgenetics.bsky.social #BCMPostdoc

Two #lysosomal genes ATP13A2 and #GBA1 interact to drive #neurodegeneration

Mingxue Gu, Jinghan Zhao, Mingxi Deng...Joshua M. Shulman & Hugo J. Bellen @bcmhouston.bsky.social #Parkinsons

link.springer.com/article/10.1...

Multi-omics insights into GBA1-associated Parkinson’s disease: interplay of genomics, transcriptomics, proteomics, and lipidomics - Molecular Neurodegeneration Molecular Neurodegeneration - Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder worldwide. The pathogenesis of PD is driven by multifactorial mechanisms...

Multi-omics insights into #GBA1 -associated #Parkinsons disease: interplay of #genomics, #transcriptomics, #proteomics, and #lipidomics

Yang Ni, Huaibin Cai, Yaping Shao, Weidong Le

link.springer.com/article/10.1...

Discovery shines light on a cascade of events that occurs when toxic tau impacts synapses, suggesting new mechanisms for neurodegeneration Congrats to the Buck’s Tracy lab for their new paper in Molecular Neurodegeneration. The work describes a new mechanism for how synapses deteriorate in Alzheimer's disease and related dementias.

New mechanism for how synapses deteriorate in #Alzheimers, with new tool that maps dynamic postsynaptic changes after acute tau oligomer exposure. Study in @molneurodegen.bsky.social
@taratracylab.bsky.social

www.buckinstitute.org/news/discove...

Synaptic control of #RetinalGanglionCell survival and #axon regeneration

Yuxuan Qiu, Qi Zhang, Jiahui Tang...Yangjiani Li, Zhe Liu, Fang Chai, Yehong Zhuo, Yiqing Li

link.springer.com/article/10.1...

Tau #oligomers modulate synapse fate by eliciting progressive bipartite #synapse dysregulation and synapse loss

Kristeen A. Pareja-Navarro, Christina D. King, Grant Kauwe...Tara E. Tracy @buckinstitute.org #AlzheimersDisease #iPSCs

link.springer.com/article/10.1...

#Plasma platelet-derived growth factor receptor-β decrease correlates with #bloodbrainbarrier damage in #AlzheimersDisease

Jieyin Li, Anqi Li...Xuhui Chen, Dai Shi, Tengfei Guo

link.springer.com/article/10.1...

Systemic #complement factors in aging, #AlzheimersDisease and other dementias: a #longitudinal study over 10 years

Xiaofeng Fu, Huimin Cai, Shuiyue Quan...Longfei Jia

link.springer.com/article/10.1...

The molecular fidelity of Aβ pathology in 5xFAD and AppNL−FPsen1P117L mice revealed by #cryoEM

Meinai Song...Deng-Feng Zhang & Qin Cao #amyloid #AlzheimersDisease

link.springer.com/article/10.1...

Great study on @molneurodegen.bsky.social showcasing the differences of Aβ generated from glutamatergic and GABAergic neurons with distinct implications for plaque compaction, reactive gliosis, and axonal dystrophy!

link.springer.com/article/10.1...

Neuronal subtype governs #amyloid structure, cellular response, and cognitive outcome in genetically targeted APP mouse models

Gabriella A. Perez, Zoe Lai...Joanna L. Jankowsky
@bcmhouston.bsky.social @washumedicine.bsky.social #AlzheimersDisease #GABAergic

link.springer.com/article/10.1...

OMG! A proteomic determinant of #neurodegenerative resiliency

Michael R. Duggan, Hamilton Se-Hwee Oh, Philipp Frank...Keenan A. Walker #proteomics #AlzheimersDisease

link.springer.com/article/10.1...

Developmental dopamine loss rewires striatal circuits to promote locomotion - Molecular Neurodegeneration Molecular Neurodegeneration - Motor symptoms of Parkinson’s disease (PD) primarily result from the degeneration of nigrostriatal dopaminergic neurons (DANs), particularly the Aldehyde...

Developmental #dopamine loss rewires striatal circuits to promote locomotion

Jie Dong...Weidong Le, Jun Jia, Huaibin Cai @NIHAging @NIH #Parkinsons #optogenetics

link.springer.com/article/10.1...

Organelle stress in NLRP3 inflammasome: a central mediator of neurodegenerative diseases - Molecular Neurodegeneration Molecular Neurodegeneration - Organelle stress and NLRP3 inflammasome activation have been established as pivotal contributors to inflammatory responses and play a significant role in the...

#Organelle stress in NLRP3 #inflammasome: a central mediator of #neurodegenerative diseases

Huachao Jia, Lianghua Ma...Wanwei Jiang, Minjie Wei, Xin Zhong

link.springer.com/article/10.1...

Disrupting α-#Synuclein–ClpP interaction restores #mitochondrial function and attenuates #neuropathology in #Parkinsons disease models

Di Hu, Xiaoyan Sun, Xin Qi

link.springer.com/article/10.1...

The complement cascade in Alzheimer’s disease: modern implications of an ancient immune protagonist - Molecular Neurodegeneration Molecular Neurodegeneration - The complement system, a critical arm of innate immunity, has emerged as a key contributor to the pathogenesis of Alzheimer’s disease (AD). While...

The #complement cascade in #AlzheimersDisease: modern implications of an ancient #immune protagonist

Maria-Tzousi Papavergi, Praveen Bathini, Brijendra Singh & Cynthia A. Lemere @harvardmed.bsky.social

link.springer.com/article/10.1...

Targeted deletion of EMMPRIN in microglia/macrophages mitigates neuronal death in intracerebral hemorrhage - Molecular Neurodegeneration Molecular Neurodegeneration - Intracerebral hemorrhage (ICH) is a devastating subtype of stroke with high mortality and limited therapeutic options. Microglia and macrophages are rapidly recruited...

Targeted deletion of EMMPRIN in #microglia /macrophages mitigates neuronal death in intracerebral #hemorrhage

Zhe Li, Xiangyu Zhang, Maryam Mobarakabadi...V. Wee Yong & Mengzhou Xue #neuroprotection

link.springer.com/article/10.1...

The pesticide chlorpyrifos increases the risk of Parkinson’s disease - Molecular Neurodegeneration Molecular Neurodegeneration - Pesticides as a class have been associated with an increased risk of Parkinson’s disease (PD), but it is unclear which specific pesticides contribute to this...

"The #pesticide chlorpyrifos increases the risk of #Parkinsons disease"

Kazi Md. Mahmudul Hasan, Lisa M. Barnhill, Kimberly C. Paul...Jeff M. Bronstein @dgsomucla.bsky.social

link.springer.com/article/10.1...

DAP12 deletion reduces neuronal SLIT2 and demyelination and enhances brain resilience in female tauopathy mice - Molecular Neurodegeneration Background Pathogenic tau accumulation drives neurodegeneration in Alzheimer’s disease (AD). Enhancing the aging brain’s resilience to tau pathology would lead to novel therapeutic strategies. DAP12 (...

Our new study in @molneurodegen.bsky.social shows that microglial DAP12 controls tau buildup and drives myelin loss by mediating a harmful tau-induced SLIT2 signal from neurons to oligodendrocytes link.springer.com/article/10.1...

Diagnostic biomarkers for α-synucleinopathies- state of the art and future developments: a systematic review - Molecular Neurodegeneration Molecular Neurodegeneration - Alpha-synucleinopathies are common disorders that are expected to become increasingly prevalent in the future along with the longer life expectancy. However, their...

Diagnostic #biomarkers for α- #synucleinopathies- state of the art and future developments: a systematic review

V. Donadio, M. Ingelsson...S. Pritzkow @unibo.it

link.springer.com/article/10.1...