Federico Uliana

Direct interaction between TDP-43 and Tau promotes their co-condensation, while suppressing Tau fibril formation and seeding
@dormannlab.bsky.social
www.embopress.org/doi/full/10....

The main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII - Communications Biology SARS-CoV-2 main protease (Mpro) directly activates coagulation by cleaving factors VII and XII, showing a broader protease specificity and revealing a novel mechanism linking COVID-19 infection to thr...

SARS-CoV-2 main protease (Mpro) directly activates coagulation by cleaving factors VII and XII, showing a broader protease specificity and revealing a novel mechanism linking COVID-19 infection to thrombosis.

doi.org/10.1038/s420...

Huge kudos to Anna Pagotto (@imsb-eth.bsky.social), all collaborators, and the researchers from Vincenzo De Filippis’ team—what a journey! Grateful for the teamwork that made this possible (2/2)

The main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII - Communications Biology SARS-CoV-2 main protease (Mpro) directly activates coagulation by cleaving factors VII and XII, showing a broader protease specificity and revealing a novel mechanism linking COVID-19 infection to thr...

New work out in @commsbio.nature.com @natureportfolio.nature.com! With Anna Pagotto, we show SARS-CoV-2 Mpro has a secondary preference for R↓ beyond LQ↓. This broader specificity can directly activate the coagulation cascade. #Biochem & #Proteomics all in!
www.nature.com/articles/s42... (1/2)

Direct binding of TDP-43 and Tau drives their co-condensation, but suppresses Tau fibril formation and seeding www.biorxiv.org/content/10.1...

Direct binding of TDP-43 and Tau drives their co-condensation, but suppresses Tau fibril formation and seeding https://www.biorxiv.org/content/10.1101/2025.07.07.662960v1

PKA regulates stress granule maturation to allow timely recovery after prolonged starvation https://www.biorxiv.org/content/10.1101/2025.07.06.663161v1

Hello Bluesky! 🌤️

We're on the Molecular Cell cover!

How are ribosome levels adjusted?

Stm1 not only protects ribosomes from degradation, it also promotes their biogenesis in nutrient-rich conditions.

Two roles, one protein - tuned by nutrient availability.

🔗 www.cell.com/molecular-ce...

🚨Registration for the 13th Symposium on Structural Proteomics is open!
Milan, Oct 6–8 | Cutting-edge science and vibrant discussions.
ssp2025.squarespace.com
Proud to co-organize the SSP in Italy with Andrea Graziadei and Lolita Piersimoni @humantechnopole.bsky.social #ChiesiFarmaceutici #univaq

Interested in the molecular mechanisms of neurodegeneration?
📢 We are looking for a PhD student interested in studying the role of TDP-43 in genome stability and the DNA damage response!
Apply via this fantastic PhD Programme until April 3 👇

One more day to apply!

Quantitative workflow to probe Bik1 conformational changes. Crosslinked (XL) peptides were obtained from Bik1 FL in dilute, phase separation, supernatant, and pellet conditions. Crosslinks specific to one condition (conformo-specific crosslinks) are then employed to monitor structural rearrangements in Bik1 samples using quantitative targeted proteomics

MS Highlight: We developed a novel MS Structural approach to selectively measure conformation-specific crosslinked peptides! 🎯With this targeted method you can quantitively track protein structural changes during phase separation.💦 More data coming soon-stay tuned! (2/2) #TeamMassSpec #idp #PhaseSep

Phase separation of a microtubule plus-end tracking protein into a fluid fractal network - Nature Communications Here, the authors characterize the structural organization and condensate behavior of the microtubule plus-end tracking protein Bik1, employing SAXS, computational modeling, microscopy, and crosslinki...

Hi Blueskyers! Excited to share our work in @naturecomms.bsky.social. With the group of Michel Steinmetz(PSI) we combined quantitative XL-MS and biophysics to reveal how Bik1 dynamically rearranges in dilute and phase separated state.
www.nature.com/articles/s41...
(1/2) #TeamMassSpec#idp#PhaseSep

📢 The Dormann Lab is looking for a PhD student interested in the molecular mechanisms of neurodegeneration and biomolecular condensation!

Interested in one of our research projects on disease-linked RNA-binding proteins, such as TDP-43 and FUS?

Apply to this fantastic PhD program by February 7 👇

Loss of D1 during embryogenesis triggers transposon expression in adult ovaries. Top: Ovaries from the indicated genotypes (D1 and aubergine mutants and heterozygotes, F1 and F2) were stained with Vasa (green) and DAPI (magenta). Bottom: RNA in situ hybridization against Copia (green) and total polyadenylated mRNA (blue) was performed in ovaries of the indicated genotypes that were also stained for DAPI (magenta). Yellow and black arrowheads indicate undifferentiated germ cells in the aubergine mutant germarium.

Pericentromeric #heterochromatin clusters into chromocenters. @skrutlnize.bsky.social &co use quantitative mass spec to characterize the chromocenter proteome in multiple tissues, identifying a link between satellite DNA-binding proteins & #transposon repression🧪 @plosbiology.org plos.io/4akuNAi