Simón, @gonzamoratorio.bsky.social et al. trace the evolution of ZAP, an antiviral protein targeting CpG-rich RNA that originated >400 Mya in the tetrapod–lungfish ancestor. Their findings point to complex coevolution of host antiviral defenses.
🔗 doi.org/10.1093/molbev/msaf135
#evobio #molbio
Thank you, my friend Mateo, for welcoming me into your podcast community. It was a pleasure to share ideas and be part of such an inspiring conversation!
www.linkedin.com/posts/mateo-...
A large-scale functional screen from the Sanjuán lab (great work, again, by @Jeremy_Dufloo and colleagues) hints the entry step may be less of a hurdle to zoonosis than once believed. 👇
nature.com/articles/s4156…
Since the USDA launched its Bird Flu milk testing strategy in December, 28 states have enrolled, representing nearly 65% of the nation’s milk production. And there's a dashboard.
This was a long time coming but an impressive start.
www.aphis.usda.gov/livestock-po...
Always a fantastic time at @yalesph.bsky.social , diving into science and enjoying great company. Huge thanks to @nathangrubaugh.bsky.social for being such an incredible host for the Uruguayan crew.
This week's Nature editorial
The missed opportunities to save lives with genomic data, such as mutations in BRCA1 and 2
www.nature.com/articles/d41...
Drs. Fauci and Collins responded to the (drafts) of the SSCP GOP report, outlining some of the many falsehoods in the report, including about our paper.
The letters speak for themselves.
Dr. Fauci:
s3.documentcloud.org/documents/25...
Dr. Collins:
s3.documentcloud.org/documents/25...
9/ Collaborative efforts spanning disciplines and geographies were crucial for this work 🇦🇷🇺🇾🇺🇸🇨🇦. You have it here: www.nature.com/articles/s41...
8/ These findings suggest a novel aspect of coronavirus pathogenesis, highlighting potential therapeutic opportunities focused on targeting virus-heme interactions.
7/ A drug known to interact with heme/hemin impairs hemin’s pro-infective effect, reducing systemic infection. This further supports the hypothesis of heme-enhanced infection.
6/ Intriguingly, hemin (a heme analog) administration in infected mice elevated viral loads in organs and RBCs, underscoring the role of heme, and potentially hemoproteins, in enhancing viral infectivity.
5/ Spectroscopic analysis revealed that SARS-CoV-2 Spike protein interacts with hemin, altering its absorption spectrum.
4/ Using in silico molecular modeling 🖥, we predicted specific binding interactions between Spike and heme, revealing a potential mechanism that supports viral dissemination.
3/ We observed viral particles closely associated to red blood cells (RBCs) by proteomics and high-resolution transmission electron microscopy. These findings highlight a potential mechanism for Coronaviruses’ systemic spread ✈️
2/ Employing “the Polio virus” of coronaviruses, MHV, and its natural host 🐁 , we detected viral RNA and particles across multiple organs and blood 🩸 compartments, corroborating systemic tropism observed in our data from human autopsy.
1/ How does coronaviruses influence systemic physiology beyond target organs? Our recently paper offers insights into Coronavirus Bloodlust🧛🏽♂️. Let’s dive into it.
And every day, the likelihood of events like these occurring continues to grow
Thanks so much @rongellerlab.bsky.social and team!!!
Celebrating with our newest Dr. when I am submitting a story that drove us happily insane in every scientific discussion!!! Whatever the outcome, we celebrate every battle and every step forward. The happiness of his face says it all!!!
Why the large language models of today cannot reach AGI, a new Nature feature www.nature.com/articles/d41...
Grande Nacho!!! Acá estoy atrás de un par de carretas y el morocho Ansina metiendo “la redota”!!!
