The Wikipedia model seems good. Better than ads. Also better than allowing users to pay for extras - that tilts the playing field.

(7/7) Kudos to the Codebook and GRECO-BIT consortium members including ‪@halfacrocodile.bsky.social‬ and @bartdeplancke.bsky.social. See the whole team at ibis.autosome.org/docs/about_us

(6/7) 1,421 human TFs now have a characterized DNA-binding specificity, and nearly all 1,638 have been assayed. Analyses in doi.org/10.1101/2024... indicate, however, that many previously characterized TF binding specificities may be inaccurate.

(5/7) Collectively the uncharacterized TFs bind directly to tens of thousands of conserved sequences, providing biochemical functions for these sites. Intriguingly, many of these sites are in genomic “dark matter”. Explored further in doi.org/10.1101/2024...

(4/7) Methods for PWM discovery and benchmarking are explored in detail in an accompanying manuscript: doi.org/10.1101/2024...

(3/7) Of the 332 uncharacterized TFs, PWMs were identified for 177, the vast majority of which have unique and previously unseen motifs.

(2/7) We applied five different assays to 332 uncharacterized TFs (i.e., Codebook TFs) and 61 control TFs, including a new assay, GHT-SELEX, described in: doi.org/10.1101/2024...

Perspectives on Codebook: sequence specificity of uncharacterized human transcription factors We describe an effort (“Codebook”) to determine the sequence specificity of 332 putative and largely uncharacterized human transcription factors (TFs), as well as 61 control TFs. Nearly 5,000 independ...

(1/7) Thrilled to reveal the results of the Codebook Project, an international effort to identify accurate DNA-binding motifs and genomic binding loci for the >300 uncharacterized human transcription factors (TFs) doi.org/10.1101/2024...

Uh oh. If we need to fix something, can you email me directly?