bioRxiv Immunology

Epithelial sensing of vitamin A shapes intestinal antimicrobial defense https://www.biorxiv.org/content/10.64898/2026.03.08.710399v1

One and Done: A safe, adaptable single-cycle SARS-CoV-2 vaccine platform blocks XBB.1.5 infection and transmission https://www.biorxiv.org/content/10.64898/2026.03.09.709481v1

A cell surface proteomic atlas reveals socioeconomic status associated immune diversity https://www.biorxiv.org/content/10.64898/2026.03.07.707513v1

Antibody recycling via FcRn drives atherosclerotic plaque vulnerability https://www.biorxiv.org/content/10.64898/2026.03.08.710352v1

Stochasticity in viral infection and host response: A competition between speed and reliability https://www.biorxiv.org/content/10.64898/2026.03.08.710362v1

Esophageal epithelial cell-state transitions underlie the severity of pediatric eosinophilic esophagitis https://www.biorxiv.org/content/10.64898/2026.03.07.710295v1

IL-17RC signaling connects intestinal microbiota and neuroimmune interactions in atherosclerosis https://www.biorxiv.org/content/10.64898/2026.03.06.710205v1

Acute Paternal Immune Activation Shapes Embryonic Development and Protects Offspring from Viral Infection https://www.biorxiv.org/content/10.64898/2026.03.06.710215v1

Mapping the Modification Landscape of MHC-I Epitopes: A Framework for Immunogenic Peptidomimetic Antigen Design https://www.biorxiv.org/content/10.64898/2026.03.06.710184v1

Contribution of cytotoxic CD8 T cells, neutrophils and type 1 interferon signaling to hyperinflammatory pathology in HIV associated TB meningitis https://www.biorxiv.org/content/10.64898/2026.03.10.710544v1

Preclinical characterization of immune responses induced by a candidate gonococcal native Outer Membrane Vesicle vaccine https://www.biorxiv.org/content/10.64898/2026.03.09.710637v1

HIV-1 Vpr counteracts TASOR restriction to promote infection prior to integration https://www.biorxiv.org/content/10.64898/2026.03.06.710055v1

Functional alterations of immune gene expression in ICU and non-ICU patients with Legionnaires' disease, a prospective observational study https://www.biorxiv.org/content/10.64898/2026.03.06.709905v1

Hemoperfusion of pigs with a carbon-cellulose cartridge: a pilot study revealing a new animal model of extended anaphylactic shock https://www.biorxiv.org/content/10.64898/2026.03.05.709860v1

Amoxicillin induces gut dysbiosis leading to long term suppression of type-17 immune tone in the lungs https://www.biorxiv.org/content/10.64898/2026.03.05.709937v1

Improving the immunogenicity of E. coli FimH via multivalent display on I53-50 nanoparticles https://www.biorxiv.org/content/10.64898/2026.03.05.709951v1

Single cell analysis of neonatal naïve CD8α+ T cells reveals novel subsets bridging the innate-adaptive spectrum https://www.biorxiv.org/content/10.64898/2026.03.05.706693v1

TET2-mutant clonal hematopoiesis prevents T-cell exhaustion and suppresses cancer metastasis https://www.biorxiv.org/content/10.64898/2026.03.05.709727v1

Minimal-invasive myocardial infarction model reproduces patient immune responses and reveals a pathogenic role for immature neutrophils https://www.biorxiv.org/content/10.64898/2026.03.05.709757v1

Dirty mice better recapitulate key features of mRNA vaccine immunogenicity observed in humans https://www.biorxiv.org/content/10.64898/2026.03.07.709392v1

Mast Cell Specific Cyp11a1 Deficiency Promotes T Cell Mediated Immunity and Suppresses Tumour Metastasis in a Mouse Model of Melanoma https://www.biorxiv.org/content/10.64898/2026.03.04.709617v1

Selective JAK Inhibition Reveals Paradoxical and Hierarchical Control of interferon-γ-driven Autoimmunity in AIRE Deficiency https://www.biorxiv.org/content/10.64898/2026.03.05.709894v1

Comprehensive Mapping of Immune Nanobody Repertoires with NanoMAP https://www.biorxiv.org/content/10.64898/2026.03.05.709882v1

IFI207 promotes antiviral responses by modulating STING ubiquitination and degradation https://www.biorxiv.org/content/10.64898/2026.03.05.709838v1

A post-translational regulatory map of chronic antigen-driven human T cell dysfunction. https://www.biorxiv.org/content/10.64898/2026.03.04.709614v1

Early clonal dominance at priming sets the trajectory for broad HIV serum neutralization https://www.biorxiv.org/content/10.64898/2026.03.04.709621v1

Autosomal dominant CDC45 deficiency with allelic expression bias causes a novel genetic disease of the immune system https://www.biorxiv.org/content/10.64898/2026.03.04.709645v1

A Novel Monocyte-derived Antigen Presenting Cell-T regulatory Cell Axis Contributes to Skin Wound healing and is Impaired in Diabetic Mice https://www.biorxiv.org/content/10.64898/2026.03.04.709590v1

Cannabis Use by People with HIV is Associated with an Anti-Inflammatory Immunometabolic Phenotype in Monocyte-Derived Macrophages https://www.biorxiv.org/content/10.64898/2026.03.04.709579v1

IL-2- and IL-4-dependent signaling play separate and sequential roles in the differentiation of GATA3-hi TH2 cells in vivo https://www.biorxiv.org/content/10.64898/2026.03.04.709484v1