David A. Hill, MD, PhD's Avatar

David A. Hill, MD, PhD

@drdavidhill

Physician-Scientist and Attending Physician at the University of Pennsylvania and Children's Hospital of Philadelphia studying how #diet and the #microbiome influence #immune #health and #inflammatory #disease. Web: https://www.med.upenn.edu/hilllab/

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21.02.2025
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Latest posts by David A. Hill, MD, PhD @drdavidhill

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Had a great conversation with Pittsburgh Mayor Corey O’Connor on pediatric health, education, and environmental initiatives—and how partnerships between cities, hospitals, and universities can translate science into healthier futures for children and communities. @coreyoconnorpa.bsky.social #PGH

10.03.2026 14:08 👍 0 🔁 0 💬 0 📌 0
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Honored to be joining the @aaaaiorg.bsky.social Foundation Council as Vice Chair for Research and Long-Range Planning. Looking forward to partnering with Elizabeth Phillips and the Council to help guide the Foundation’s research vision for the coming decade. #AAAAI

09.03.2026 13:43 👍 1 🔁 0 💬 0 📌 0

Honored and excited to join the Editorial Board at @allergy-eaaci.bsky.social! The flagship journal of the European Academy of Allergy and Clinical Immunology. #EAACI #Allergy

09.03.2026 13:33 👍 3 🔁 0 💬 0 📌 0
JCI Insight - CD9 regulates macrophage-mediated remodeling of adipose tissue in obesity

Excited to share new work from our lab in @insight.jci.org 🎉

We find that #CD9 is a key regulator of adipose tissue lipid-associated macrophages #LAMs in obesity. Deleting CD9 improves metabolism in obese mice.

Credit to first author Julia Chini and team!

Read now:
insight.jci.org/articles/vie...

06.03.2026 16:41 👍 8 🔁 2 💬 1 📌 0
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Proton pump inhibitors modulate esophageal epithelial barrier function and crosstalk with eosinophils - PubMed Omeprazole diminished the effects of IL-13 in both the epithelial air-liquid interface model and eosinophil-epithelial co-cultures, alleviating barrier dysfunction, chemokine expression, and the upregulation of eosinophil adhesion markers.

Check out this new article on #PPIs in #EoE from CHOP physician-scientist Melanie Ruffner and her lab.

pubmed.ncbi.nlm.nih.gov/41760554/

02.03.2026 13:01 👍 1 🔁 1 💬 0 📌 0
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Eosinophilic Esophagitis Incidence during Single and Multiple Food Oral Immunotherapy - PubMed In a cohort of 1200 children on OIT at a tertiary pediatric hospital with robust OIT and EoE programs, the rate of newly diagnosed EoE during OIT was found to be 0.7%, which is lower than prior studies. This study demonstrated regular screening before and during OIT is associated with a reduced rate …

Check out this new article on #EoE during #OIT from CHOP researchers Tim Buckey, Antonella Cianferoni, and others!

pubmed.ncbi.nlm.nih.gov/41763603/

02.03.2026 12:58 👍 0 🔁 0 💬 0 📌 0

Excited to attend the #AAAAI26 foundation benefit tonight. What an important event that is central to supporting so many advances in allergy and immunology!

01.03.2026 00:08 👍 0 🔁 0 💬 0 📌 0

Go see Hill Lab member Natasha Puzon‘s #AAAAI26 poster presentation on how #diet influences #asthma right now!

27.02.2026 20:58 👍 2 🔁 0 💬 0 📌 0

Go see Hill Lab member Julie Dilollo‘s #AAAAI26 poster presentation on #EoE T cells right now!

27.02.2026 20:57 👍 0 🔁 0 💬 0 📌 0

Come see past Hill Lab member and current CHOP A/I Assistant Professor Stan Gabryszewski give his talk on Artificial Intelligence in EoE at the CEGIR/TiGERS session right now! #AAAAI26

26.02.2026 20:03 👍 0 🔁 1 💬 0 📌 0

Come see Hill Lab member Julie give her oral abstract at the CEGIR/TiGERS session right now!

26.02.2026 18:00 👍 0 🔁 0 💬 0 📌 0
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What would your vote be?

26.02.2026 15:15 👍 0 🔁 0 💬 0 📌 0
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Congratulations to all of the #AAAAI26 Foundation awardees!

26.02.2026 13:29 👍 0 🔁 0 💬 0 📌 0

Very excited for the first day of #AAAAI26! Welcome to Philadelphia!

26.02.2026 13:27 👍 1 🔁 0 💬 0 📌 0
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What if dietary fat acts as an immune signal?

In our new review, we explore how saturated fatty acids activate conserved inflammatory pathways, shape immune cell function, and may represent an evolutionarily conserved host defense mechanism. Look for it soon in DNA and Cell Biology!

18.02.2026 23:59 👍 0 🔁 0 💬 0 📌 0
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🎉 Excited to share that our newest manuscript has been accepted in @insight.jci.org!

We identify CD9 as a key regulator of macrophage-driven adipose remodeling, linking immune–stromal crosstalk to metabolic dysfunction in obesity!

Stay tuned!

#obesity #immunometabolism #macrophages #adiposetissue

29.01.2026 14:33 👍 4 🔁 1 💬 0 📌 0

Big thanks to our funders: #FoodAllergyFund, @aaaaiorg.bsky.social, @apfed.bsky.social, @chopresearch.bsky.social, and others!

13.01.2026 00:06 👍 1 🔁 0 💬 0 📌 0

2026 is off to a great start...🚨New publication alert!🚨

Our latest paper is out in Diagnostics!

🧬 We show that functional T-cell blood tests accurately predict milk and soy allergy in EoE, an important step towards a clinical test!

🔗 Read the full paper here: www.mdpi.com/2075-4418/16...

13.01.2026 00:03 👍 1 🔁 0 💬 2 📌 0

Had a great time at the #GordonFoodAllergy conference last week! What a wonderful community of highly dedicated investigators!

11.01.2026 14:37 👍 0 🔁 0 💬 0 📌 0
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The CHOP Allergy and Immunology Division has a new recent publications board! Look at all that new knowledge… but the best is yet to come!

11.01.2026 14:20 👍 1 🔁 0 💬 0 📌 0

BIG thanks to our funders: The Food Allergy Fund, @aaaaiorg.bsky.social, @apfed.bsky.social, The Hartwell Foundation, and others!

26.12.2025 16:40 👍 1 🔁 0 💬 0 📌 0
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Excited to share our latest work, soon to be published in Diagnostics!

This trial of >200 patients showed high performance for the #EoE #Food #Test! This transformational technology is now under development by the CHOP Clinical Immunology Lab.

Stay tuned to know when the paper drops!

26.12.2025 16:39 👍 2 🔁 0 💬 1 📌 0
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Oesophageal Epithelial Cell‐Intrinsic MHCII Regulates Food Antigen‐Dependent Eosinophilic Esophagitis in an IFNγ‐Dependent Manner We found that oesophageal epithelial cells upregulate MHCII expression during active EoE in humans and a mouse model. MHCII expression by EECs was governed by IFNγ-inducible transcriptional elements....

Just in time for the holidays...🚨New publication alert!🚨

Our latest paper is out in Clinical and Experimental Allergy!

The esophagus is not just for food transport! Esophageal epithelial cells help to control allergic inflammation via expression of MHCII!

onlinelibrary.wiley.com/doi/10.1111/...

23.12.2025 21:09 👍 2 🔁 0 💬 0 📌 0
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Seven feel-good science stories to restore your faith in 2025 Immense progress in gene editing, drug discovery and conservation are just some of the reasons to be cheerful about 2025.

www.nature.com/articles/d41...

22.12.2025 21:41 👍 1 🔁 0 💬 0 📌 0
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The Nuremberg Code and Its Lasting Relevance to Allergy and Immunology - PubMed The Nuremberg Code and Its Lasting Relevance to Allergy and Immunology

Check out this new editorial from CHOP attending Tim Buckley!

pubmed.ncbi.nlm.nih.gov/41423097/

22.12.2025 11:47 👍 2 🔁 0 💬 0 📌 0
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Excited to share our latest work, soon to be published in Clinical & Experimental Allergy!

We uncover a protective role for #IFN-γ–induced epithelial MHCII in limiting eosinophilic inflammation in #EoE!

Big thanks to the funders including @aaaaiorg.bsky.social!

Stay tuned to know when it drops!

12.12.2025 16:41 👍 0 🔁 0 💬 0 📌 0
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Feeding kids with food allergies can be expensive. So CHOP opened a pantry to help families access allergen-free staples Households that struggle to pay for items like egg substitute and soy milk can find them at the health system's Buerger Center. And a delivery program is in the works.

Way to go, @childrensphila.bsky.social Allergy and Immunology!

nam10.safelinks.protection.outlook.com?url=https%3A...

12.12.2025 15:45 👍 1 🔁 0 💬 0 📌 0
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Peanut Allergy Prevention: What we have learned from early introduction (Episode 206) Podcast Episode · Primary Care Perspectives · 12/09/2025 · 30m

Check out @chopresearch.bsky.social Allergy/Immunology Dr. Stan Gabryszewski speaking on Katie Lockwood’s Primary Care Perspectives Podcast about our latest peanut allergy study!

podcasts.apple.com/us/podcast/p...

09.12.2025 16:28 👍 0 🔁 0 💬 0 📌 0

It’s paper submission (and resubmission) day!

07.12.2025 20:34 👍 0 🔁 0 💬 0 📌 0

I really enjoyed speaking with Stephanie on Public Health On Call. Please help to get the word out that early allergen introduction is safe and effective!

24.11.2025 17:42 👍 1 🔁 2 💬 0 📌 0