Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social
doi.org/10.1016/j.ce...
Read the thread👇 for the highlights of our findings.
The function of nuclear speckles is revealed! This is an incredibly important paper with absolutely beautiful data! Wow! www.cell.com/cell/fulltex...
Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now?
www.nature.com/articles/s41...
More functional data, many thousands of words removed, and a few other updates from last year's preprint.
3️⃣4️⃣ Robert G. Roeder collecting sea urchings, the organism in which eukaryotic RNA Pols I, II and III were discovered
(source : youtu.be/efNtZyXSHC4?...)
🧪🧬New preprint We present cryo-EM structures of reconstituted CTCF–nucleosome complexes, showing CTCF dimerization drives nucleosome oligomerization into defined higher-order assemblies. Disrupting CTCF–CTCF interfaces in mESCs reduces looping and impairs differentiation. tinyurl.com/CTCF-nucleos...
I feel the same way! I have learned a great deal from you and the team through many thoughtful and invigorating discussions over the last 2+ years.
You can access a free download until March 28 using this link: authors.elsevier.com/c/1mZlb3vVUP...
We also discuss best practices for studying the functional roles of density transitions, potential pitfalls in studying these phenomena, and speculate on how emergent properties may regulate transcription.
I am excited to share a new review @cp-molcell.bsky.social written in collaboration with @tanjamittag.bsky.social , Mikayla Eppert, and Ambuja Navalkar where we review the current evidence for and against the role of density transitions in regulating transcription www.cell.com/molecular-ce...
Now published in @science.org
www.science.org/doi/10.1126/...
New preprint from the lab! We identify the ZnF protein Mulberry as a condensation-dependent structural regulator of genome topology that organizes “multi-way regulatory hubs” in early Drosophila embryos.
www.biorxiv.org/content/10.6...
Poster showing program for IDPSeminars on Feb 5th. Talks are: Lucia Strader: IDR sequence features of activation domains Heather Meyer: IDPs as environmental sensors and actuators in plants
IDPSeminas is back again TOMORROW!
Talks from Lucia Strader (@luciastrader.bsky.social) and Heather Meyer! Sign up at idpseminars.com.
Talks start at 1 pm EST / 7 PM CET!! Come learn about transcriptional adaptation and IDRs as environmental sensors and accuators!
This is an excellent environment for scientists aiming to build an independent research program grounded in rigor and conceptual clarity. Please email me your CV and a brief statement of interests.
The lab is funded and growing, with multiple projects addressing fundamental and disease-relevant questions. This position is well suited for someone who values mechanistic over descriptive science and wants to help shape an emerging field.
Strong training in molecular biology or biochemistry and a solid publication record are essential. Experience with engineering mammalian cell lines, functional genomics, protein biochemistry, and/or quantitative fluorescence microscopy is a plus.
I am recruiting postdoctoral fellows to develop new research directions in the lab. We study transcriptional regulation through biomolecular condensates in development and disease, with an emphasis on first-principles and mechanistic discovery. Please repost or share with colleagues.
Activator-promoter compatibility in mammals - Hcfc1 is a key and intrinsically CGI-promoter-specific co-activator that cannot activate non-CGI promoters. Lead by @nemcko.bsky.social & Kevin Sabath in collab. with @plaschkalab.bsky.social @impvienna.bsky.social www.biorxiv.org/content/10.6... (1/2)
Do transcriptional activators work on any promoter? Our data says no. 🙅♂️
Despite driving ~2/3 of mammalian genes, CpG island (CGI) promoters have remained a puzzle. We identified >50 activators that are exclusively compatible with this promoter class. 🧬
🎉Publication alert🎉
Congratulations to @lemkelab.bsky.social, @wittmann-lab.bsky.social, Girard Lab & their teams on their new Nature Communications publication. This work showcases the active cross-disciplinary dialogue that lies at the heart of our network. www.nature.com/articles/s41...
@science.org 🧬🔬 Multiscale structure of #chromatin condensates explains phase separation and material properties | Science www.science.org/doi/10.1126/... @janhuemar.bsky.social et al.
Our Science paper is out!
Huge congratulations to @huabin-zhou.bsky.social, Mike Rosen, and the brilliant @janhuemar.bsky.social @juliamaristany.bsky.social and @kieran-russell.bsky.social from our group
News: bit.ly/4avnkAr and bit.ly/3XBGVHS
Great perspective by @vram142.bsky.social +K Zhang
Love this; inspired by early experiences and cemented by the incomparable @jiwasa.bsky.social at an incredible workshop she and @theroglab.bsky.social organized in '22, I've become thoroughly convinced that - at least for me - developing figures from scratch is a key part of scientific inquiry.
Anthony A. Hyman will become EMBL’s next Director General.
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
6 years ago, Lizz took a leap of faith by moving across the country to join our new and empty lab as a research tech. She then became our 1st grad student, playing a major role in shaping our research directions and lab culture. Today she defended her PhD, and I couldn’t be more proud.
Congrats, Josh! Exciting work!
(1/10) How do diverse leukemia mutations converge on the same molecular program? In #RibackLab first manuscript @cp-cell.bsky.social, collaboration with @goodell-lab.bsky.social shows that disparate mutations rewire shared protein networks to form nuclear condensates called C-bodies.
What do the naked mole rat and bowhead whale (lives to ~200 years) have in common to explain their remarkable longevity?
Enhanced DNA repair
www.nature.com/articles/s41...
erictopol.substack.com/p/a-long-awa...
Thanks Krishna!
Big thank you to Hue Sun Chan, @jonaswessen.bsky.social, Nancy De La Cruz, and @heankel.bsky.social for making this wonderful interdisciplinary collaboration a success.
This is all part of a bigger story related to the IDR "specificity code" and the IDR sequence-function relationship, and provides compelling evidence that specificity can be encoded within the chemical patterns of amino acids and the multivalent networks they enable.
