No joke: I got angry hate mail today for writing an obituary of a Black woman scientist—because the person felt she did didn’t deserve the recognition.
Which just makes me want to share it again: www.nature.com/articles/d41...
Can proteins fold and function with half of the amino acid alphabet?
Using only 10 residues, we designed stable, mutation-resilient structures—no aromatics or basics involved.
A minimalist foundation for ancient biology and synthetic design. tinyurl.com/37t8br4v
#ProteinDesign #OriginsOfLife
Download it here: www.tandfonline.com/eprint/DUBR5...
Electric field-induced destabilization and surface modulation of Aβ42 fibrils in molecular simulations: theoretical implications for direct current stimulation in Alzheimer’s disease www.tandfonline.com/doi/full/10....
Excited to see this work on the cover of #MolecularCell. A massive, open #cryoEM #cryoET dataset capturing molecular organization inside intact cells, pushing what’s possible for #visualproteomics, method development, and computational reuse. Congratulations to the authors.
ter.li/of4cgh
Targeting the histone‐fold dimerization interface of oocyst rupture proteins from Plasmodium berghei for antimalarial inhibitor discovery - Ballabio - The FEBS Journal - Wiley Online Library febs.onlinelibrary.wiley.com/doi/full/10....
RE: https://mastodon.online/@Centre_Mersenne/115661990703325565
Society journals adopting the diamond open access model with financial support from science funding bodies and research institutions is a key step towards getting us out of the mess academic publishing currently is. This is […]
I just published: ERC-Plus: jackpot science or missed chance to fix academia?
My reflections on ERC-Plus, Europe’s newest ultra-competitive research grant and what it tells us about the academic culture we’re building.
medium.com/p/erc-plus-j...
All data are available on Zenodo and we'd love to see what you can do with it! Cydney also made a nice notebook to run the predictive model (including DMS scan) in Colab!
Preprint: biorxiv.org/content/10.1...
Colab: colab.research.google.com/drive/1KNWvG...
Data: docs.google.com/forms/d/e/1F...
New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!
Proud to have contributed to this work by Tiberi, Lapi, Gourlay et al rdcu.be/eQNZq
I fully endorse this. Political leaders are falling prey to AI hype, and seem to lack any kind of help from reputable sources who could counter the false claims of tech CEOs. Where are their science advisers???
The idea is to decouple the journals from the review step. They’ll still exist, but they’ll need to add other value. They’ll highlight, curate, add new perspectives. If they do a good job they can still be prestigious (like Scientific American or Wired) (1.2) 👇
A new tutorial manuscript is out! 🚀 Making @plumed.org fly: a tutorial on optimizing performance, by Daniele Rapetti, @bonomimax.bsky.social @carlocamilloni.bsky.social @bussigio.bsky.social and Gareth Tribello. arxiv.org/abs/2511.02699
It’s official: ChatGPT can't draw a GPCR, but you’ll master them in the Filizola Lab
😜 Join Us! (send your CV and the names of at least two references to my institutional email) #Postdoc #scientist #research
Snapshot of a condensate near a lipid membrane with Swedish Research Council and Malmö University logos.
I'm hiring for a PhD position at Malmö University, Sweden!
The project will focus on molecular modelling of proteins, lipids, and biomolecular condensates at cell membranes.
More details and application form: tinyurl.com/4zm92365
Please feel free to share!
@vetenskapsradet.bsky.social | @mau.se
We asked what a strong static EF may do to AB42 fibril, we saw a marked perturbation of the fuzzy coat and increase fluctuations of the fibril core
Apple is entering the protein folding arena.
SimpleFold: Folding Proteins is Simpler than You Think arxiv.org/abs/2509.18480 🧬🖥️🧪 github.com/apple/ml-sim...
RFdiffusion3 is here! We train a general network that explicitly models every atom and use it to design active enzymes and DNA binders.
Tremendous team effort with Jasper, Rohith, Raktim, Rafi, Yanjing, Paul, Jonathan, and many others!
Check it out: lnkd.in/eiUFfJaM.
AtomWorks is out! Building upon @biotite_python, we built a toolkit for all things biomolecules and trained RF3 with it. All open-source, test it via `pip install atomworks`!
AtomWorks: github.com/RosettaCommo...
RF3: github.com/RosettaCommo...
Paper: tinyurl.com/y2w4z65b
1/6
RosettaFold 3 is here! 🧬🚀
AtomWorks (the foundational data pipeline powering it) is perhaps the really most exciting part of this release!
Congratulations @simonmathis.bsky.social and team!!! ❤️
bioRxiv preprint: www.biorxiv.org/content/10.1...
🚀 Super excited to share our new work, led by @vschnapka.bsky.social bAIes, a Bayesian framework for generating accurate atomic-resolution ensembles of IDPs using #AlphaFold info! Now on @biorxivpreprint.bsky.social → feedback welcome! @pasteur.fr @erc.europa.eu
www.biorxiv.org/content/10.1...
the JIF 👇 is a very (!) narrow definition of "impact" = cites in first 2y after publication...
👉 What about "constant" or "late" impact?
👉 Why do we accept that a private company defines our impact?
👉 Why do we allow to be judged on this basis?
#researchintegrity #chemsky, #compchemsky
Rapid, nanoscale dynamics of individual IDPs determine bulk properties of the entire condensate, such as viscosity.
Amazing work by Nicola Galvanetto & the Schuler lab!
www.pnas.org/doi/10.1073/...
Congratulations to Michele Parrinello for receiving the ESI Medal 2025!
@esivienna.bsky.social
@univie.ac.at
A graphic for the Marie Skłodowska-Curie Actions (MSCA), showing a historical portrait of Marie Skłodowska-Curie overlaid with an image of four young researchers walking down a hallway. The European Commission logo is in the top left. Text reads: "Marie Skłodowska-Curie Actions – €404.3 million to support postdoctoral researchers”
Choose Science. Choose Europe.
A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.
With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.
Apply by 10 September → europa.eu/!fBTMgF
What an incredibly cool paper! While knot theory strictly applies to closed curves, Tommy, @smnlssn.bsky.social , and @paulrobustelli.bsky.social show that writhe, a knot "non-invariant" that changes with smooth deformations, provides a meaningful descriptor for flexible conformations.
onlinelibrary.wiley.com/doi/10.1002/... Federico
did some modeling to make some hypothesis on the interaction of anthocyanin with glucose transporter
Protein folding, binding and redox conditions by Stefano Gianni team in Rome the super productive Valeria Pennacchietti,
doi.org/10.1016/j.ij...
