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Carlos A. Sánchez León

@carlosasleon

In vivo electrophysiology+2P calcium imaging. Postdoc at UCLA. Neuroscientist and gamer. Trying to understand how the brain works while enjoying the journey.

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15.04.2025
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Latest posts by Carlos A. Sánchez León @carlosasleon

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Este sábado 21 a las 10:30 estaremos en la plaza del ayuntamiento de Toledo en la concentración "El valle no se vende, el valle se defiende"
Quieren convertir la naturaleza que rodea Toledo en un parque temático destruyendo las especies que ahí habitan, algunas protegidas ¿Lo vas a permitir?

16.02.2026 17:03 👍 29 🔁 18 💬 2 📌 0
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Hoy he tenido la oportunidad de compartir en el CTIF Madrid Sur la sesión “Cartografía del presente: comprender el mundo actual”, un recorrido pensado para docentes que buscan herramientas para explicar la complejidad geopolítica en el aula sin caer en simplificaciones. @oglobalpod.bsky.social

12.02.2026 21:12 👍 2 🔁 4 💬 1 📌 0
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Estremaúra n’iviernu. Dehesa, una tardi de jeneru.

📷daviddcoba

15.01.2026 21:13 👍 65 🔁 10 💬 2 📌 0

With some trepidation, I'm putting this out into the world:
gershmanlab.com/textbook.html
It's a textbook called Computational Foundations of Cognitive Neuroscience, which I wrote for my class.

My hope is that this will be a living document, continuously improved as I get feedback.

09.01.2026 01:27 👍 585 🔁 237 💬 16 📌 10
las anclas no funcionan como crees
las anclas no funcionan como crees YouTube video by aqurate-es

Las anclas no funcionan como crees...

www.youtube.com/watch?v=uw4E...

11.12.2025 11:34 👍 13 🔁 9 💬 3 📌 0
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Hoy os contamos en nuestro podcast algunas curiosidades sobre la vida pirata, que dicen que es la vida mejor. Eso no lo tenemos tan claro, pero sí que lo vamos a pasar bien navegando los siete mares. Escúchalo ya en todas las plataformas de podcast, en Youtube o en nuestra web. www.elaprenditivo.com

04.12.2025 06:01 👍 8 🔁 6 💬 0 📌 0
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¿Sabes cuál es el origen del alfabeto que usamos hoy día? Un invento alucinante para el que tenemos que ir hasta el desierto del Sinaí para encontrarlo. Escúchalo completo en nuestro podcast: open.spotify.com/show/05xIjOr...

13.11.2025 06:01 👍 8 🔁 7 💬 0 📌 0
La Santa Compaña: stranger things en la Galicia profunda
La Santa Compaña: stranger things en la Galicia profunda YouTube video by El Aprenditivo

El mejor momento para verlo o escucharlo. Feliz y terrorífica noche de #Halloween.

youtu.be/jxct9DU1LOw?...

31.10.2025 22:39 👍 5 🔁 3 💬 0 📌 0
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Volvemos con nuestro diario. Hoy os dejamos solamente un regalo visual. Os presentamos las versiones alternativas verdes de nuestra imagen. Verde oliva, claro. ¿A que son geniales?

09.10.2025 11:30 👍 2 🔁 4 💬 0 📌 0
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Chemotherapy modulation by a cancer-associated microbiota metabolite Martinez-Martinez et al. combine a host-microbe-drug-nutrient screen with multi-omics to reveal how the cancer-associated microbiota modulates chemotherapy. They identify 2-methylisocitrate, a microbi...

Excited to share our latest work at Cabreiro lab!

Chemotherapy modulation by a cancer-associated microbiota metabolite

www.cell.com/cell-systems...

Here's what we discovered 🧵

10.09.2025 19:28 👍 6 🔁 4 💬 1 📌 1

📜 Hace hoy 142 años, Badajoz amanecía tomada por militares republicanos. Un pronunciamiento olvidado intentó restaurar la República desde el corazón extremeño. Aquí va la historia de una ciudad sitiada por ideales. 🧵Hilo🧵

05.08.2025 17:14 👍 39 🔁 20 💬 3 📌 0

El mejor lugar del mundo en el mejor momento de su historia.

Saldrá en todas las portadas.

08.07.2025 16:16 👍 473 🔁 208 💬 19 📌 6
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Cerebellar tDCS differentially modulates sensory inputs in somatosensory cortex and cerebellum Cerebellar transcranial direct-current stimulation (Cb-tDCS) is a promising tool for non-invasive modulation of cerebellar activity and has been proposed for the treatment of cerebellum-related disord...

🧵1/
🚨 New preprint out!
We investigated how cerebellar transcranial direct current stimulation (Cb-tDCS) modulates sensory processing both locally in Crus I/II and distally in primary somatosensory cortex (S1) in awake mice.
📄 www.biorxiv.org/content/10.1...

30.06.2025 09:17 👍 2 🔁 1 💬 1 📌 0

Como hay gente que cree que es un truco o que os os estoy engañando, aquí tenéis un frame del vídeo. Mide las rayas de colores, de un extremo a otro (sin tener en cuenta las puntas de flecha). Cualquiera de ellas. Son todas iguales, compruébalo

29.06.2025 13:40 👍 49 🔁 11 💬 5 📌 0

Dynamic recruitment of PV interneurons in the somatosensory cortex induced by experience dependent plasticity https://www.biorxiv.org/content/10.1101/2025.06.27.662081v1

29.06.2025 00:15 👍 5 🔁 2 💬 1 📌 0

Very happy to see this message that science publishers are not only a waste of money, but are actually distorting the scientific process itself, slowing down progress. This has been the key argument for me for a while. The waste of resources is bad, but the distortion of science is unforgivable.

22.05.2025 20:36 👍 19 🔁 2 💬 1 📌 0
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A reduced ability to discriminate social from non-social touch at the circuit level may underlie social avoidance in autism - Nature Communications Social touch is critical for communication to impart emotions and intentions. However, certain autistic individuals experience aversion to social touch. Here, we used Neuropixels probes to record neur...

Really cool new science from the Portera-Cailliau lab on the neural circuit basis of social touch avoidance in a mouse model of Fragile X Syndrome. link.springer.com/article/10.1...

20.05.2025 04:11 👍 4 🔁 2 💬 0 📌 0
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🎙️ En el episodio de @elabrazodeloso.bsky.social de esta semana volvemos a nuestra serie sobre Botánica y lo hacemos con dos elementos fundamentales en nuestro viaje hacia el conocimiento más profundo del mundo natural 🌱

#ElAbrazodelOso #Podcast #iVooxOriginals #Botánica

11.05.2025 06:51 👍 8 🔁 7 💬 1 📌 1
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Translatome profiling reveals opposing alterations in inhibitory and excitatory neurons of Fragile X mice and identifies EPAC2 as a therapeutic target. Symptoms of Fragile X Syndrome (FXS), the leading monogenic cause of intellectual disability and autism, are thought to arise from an excitation/inhibition (E/I) imbalance. Here, we leverage cell type...

www.biorxiv.org/content/10.1...

25.04.2025 20:17 👍 2 🔁 1 💬 5 📌 0
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La neurociencia de la desinformación ¿Cómo decide nuestro cerebro si compartimos o no desinformación? Una investigación reciente relacionada con los circuitos neuronales sugiere que la desinformación cumple una función social, y que comp...

La neurociencia de la desinformación @theconversation.com

ttps://theconversation.com/la-neurociencia-de-la-desinformacion-255121?utm_medium=article_clipboard_share&utm_source=theconversation.com

24.04.2025 06:38 👍 7 🔁 6 💬 0 📌 0

Finally out! Check my previous thread for a quick look:
bsky.app/profile/carl...

In @elife.bsky.social: Somatodendritic orientation determines tDCS-induced neuromodulation of Purkinje cell activity in awake mice doi.org/10.7554/eLif...

21.04.2025 21:07 👍 8 🔁 4 💬 1 📌 0
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a man in a suit and tie is giving a thank you sign . ALT: a man in a suit and tie is giving a thank you sign .

Thanks for reading so far, especially if you are not a friend or family.

15.04.2025 17:10 👍 2 🔁 0 💬 0 📌 0
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Brain Stim Lab Brain research laboratory involved in characterizing brain mechanisms underlying non invasive brain stimulation techniques.

All this work have been possible thanks to the wonderful BRAIN STIMULATION Translational Lab translationalbrainstim.com and our collaborators 13/13

15.04.2025 17:10 👍 1 🔁 0 💬 1 📌 0

Hopefully, these results can improve tDCS effects and its efficacy for the treatment of different conditions, specially since the human brain is also highly convoluted and neurons have widely different orientations 12/13

15.04.2025 17:10 👍 0 🔁 0 💬 1 📌 0
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Finally, we used Neuropixel recordings to corroborate these results in simultaneously recorded neurons which have opposite orientations in the cerebellum, also corroborating the effect in behaving condition 11/13

15.04.2025 17:10 👍 0 🔁 0 💬 1 📌 0
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While neurons pointing away from the electrode decrease⬇️their activity for anodal stimulation and increase⬆️for cathodal (lower half). This phenomenon could be explained by the polarization of the neuron and changes in membrane resting potential (more in the paper) 10/13

15.04.2025 17:10 👍 0 🔁 0 💬 1 📌 0
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Matching the orientation of the neurons with their modulation under tDCS, we discovered that their orientation was a key factor determining tDCS effects, with neurons pointing toward the electrode increasing⬆️their activity for anodal stimulation and decreasing⬇️for cathodal (upper half) 9/13

15.04.2025 17:10 👍 0 🔁 0 💬 1 📌 0
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To solve this puzzle, we performed juxtacellular labelling of the recorded neurons in anesthetized mice, obtaining these awesome images: 8/13

15.04.2025 17:10 👍 0 🔁 0 💬 1 📌 0

We observed this heterogeneous modulation in all types of neurons in the cerebellum, among them the Purkinje cells, which are particularly interesting since they are the only output from the cerebellar cortex 7/13

15.04.2025 17:10 👍 0 🔁 0 💬 1 📌 0