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Holly Arnold

@hollyarnold

Microbiome Scientist | Assistant Professor

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03.11.2024
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Latest posts by Holly Arnold @hollyarnold

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A role for microglia in mediating the microbiota–gut–brain axis - Nature Reviews Immunology This Perspective explores how the gut microbiota influences the function and heterogeneity of microglia, highlighting their roles in neurological and neuropsychiatric disorders, and discusses the ther...

A Perspective article by @lilykeane.bsky.social, Gerard Clarke & @jfcryan.bsky.social @apcmicrobiomeirel.bsky.social proposes that microbiota–microglia cross-talk may have major implications for our understanding of neurological disorders and neuropsychiatric disease
#immunosky #microsky #microbiome

12.06.2025 15:41 👍 32 🔁 11 💬 0 📌 0
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ADD YOUR NAME: Sign the Open Letter in Support of NIH Staff Join the courageous and committed National Institutes of Health (NIH) public servants by adding your name now.

*URGENT* please support NIH research and the NIH employees who are standing up for science at the risk of losing their jobs! Sign *TODAY* in support of the Bethesda Declaration. The senate appropriations committee is reviewing the NIH budget Tuesday at 10 am. SHARE widely! 🧪

09.06.2025 14:04 👍 124 🔁 64 💬 0 📌 4
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Fight the Empire.

09.06.2025 19:09 👍 20961 🔁 5118 💬 240 📌 202
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Exciting progress! In our new preprint, we show that episymbiont Saccharibacteria can directly modulate epithelial immunity—a big step in understanding how these elusive microbes interact with the human host. Kudos to Deepak Chouhan and our amazing collaborators! www.biorxiv.org/content/10.1...

03.06.2025 12:30 👍 16 🔁 9 💬 0 📌 0
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Drosophila Genetic Database The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...

#drosophila @flybase.bsky.social request emergency funding:
"As it stands, by the end of July, 2025, there will be no future updates to FlyBase, and in the worst case scenario access to the website will also be lost" => please donate!

www.philanthropy.cam.ac.uk/give-to-camb...

03.06.2025 16:15 👍 82 🔁 102 💬 3 📌 17
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A Florida weatherman telling his viewers he can no longer be confident in his forecasts due to cuts to atmospheric science is the kind of resistance content I’m here for.

Kudos, Sir.🌦️

03.06.2025 22:00 👍 13273 🔁 4804 💬 471 📌 416
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Cutting the NIH—The $8 Trillion Health Care Catastrophe This JAMA Forum discusses the recent budget cuts to National Institutes of Health (NIH), the effects of these cuts on scientific research and health of individuals in the US, and the prospects for cha...

Viewpoint in JAMA details the consequences of the proposed cuts to NIH:

❌15% reduction in new therapies
❌reduction in life expectancy by 83M life years in the US = $8.2T
❌loss of $51B in economic output annually

All to save $20B annually. The math ain't mathin.'
jamanetwork.com/journals/jam...

30.05.2025 13:18 👍 77 🔁 65 💬 1 📌 3
NSF, NASA and NIH budgets per year, inflation adjusted from 2000-2025 along with the proposed cuts. NSF includes research component only. Massive cuts across all sectors, well below support spanning 25 years.

NSF, NASA and NIH budgets per year, inflation adjusted from 2000-2025 along with the proposed cuts. NSF includes research component only. Massive cuts across all sectors, well below support spanning 25 years.

How bad will it be? Catastrophic.

Proposed cuts to #NSF, #NIH, and #NASA will set the US R&D landscape back 25 yrs+, cause economic and job loss now, and undermine innovations to come.

But, this is the WH's *proposed* budget.

Speak up now before it is too late.

(inflation adjusted $-s below)

31.05.2025 02:50 👍 2606 🔁 1369 💬 70 📌 125

Hello! Can I be added as well?

31.05.2025 01:01 👍 1 🔁 0 💬 1 📌 0
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Early-life growth and cellular heterogeneity in the short-lived African turquoise killifish telencephalon Summary: This study charts spatial patterns of growth of the African turquoise killifish telencephalon from hatching to adulthood, and identifies the progenitors and neurons present during this phase ...

Very happy that our story on explosive telencephalon growth in killifish found its home in @biologists.bsky.social #BiologyOpen. Descriptive and simple, but gene expression in this brain is oh so beautiful. journals.biologists.com/bio/article/...

25.04.2025 14:28 👍 14 🔁 2 💬 1 📌 1
Image of several African turquoise killifish including a colorful male with red and silver scales with a yellow tail. Credit to Beate Hoppe.

Image of several African turquoise killifish including a colorful male with red and silver scales with a yellow tail. Credit to Beate Hoppe.

🗣️ #killifish researchers & facilities: The community (led by Dr. Beate Hoppe @leibnizfli.bsky.social) is conducting an anonymous survey on husbandry of the African turquoise killifish (Nothobranchius furzeri) in hopes to standardize care & refinement. 🔗 to help: survey.lamapoll.de/Global-Surve...

25.04.2025 10:55 👍 13 🔁 5 💬 0 📌 0

Me too please!

31.05.2025 00:58 👍 2 🔁 0 💬 1 📌 0

Today CLS objected to the proposed politicization of staff positions at US Science Agencies, particularly program managers whose expertise is critical to a strong and vibrant innovation ecosystem.

#ScheduleF

28.05.2025 20:28 👍 10 🔁 13 💬 2 📌 4
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Deaths from heart disease down 75%, that’s NIH.

Deaths from stroke down 75%, that’s NIH.

HIV/AIDS no longer a death sentence, that’s NIH.

99% of FDA approved drugs in the last decade, that’s NIH.

Please show this video to anyone who doesn’t understand why the NIH is so important.

28.04.2025 17:20 👍 5056 🔁 2389 💬 57 📌 72
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The South American MicroBiome Archive (saMBA): Enriching the healthy microbiome concept by evaluating uniqueness and biodiversity of neglected populations The composition and function of the human gut microbiome has been linked to multiple health outcomes across all world regions, often with region-specific associations. Unfortunately, the extent to whi...

Another step for microbiome research!🔬 New study introduces saMBA, a gut microbiome archive from South America. Understanding the full picture of gut microbiome biodiversity is crucial & saMBA is helping us get there!
@bvalderrama.bsky.social @jfcryan.bsky.social

www.biorxiv.org/content/10.1...

21.04.2025 11:57 👍 11 🔁 4 💬 0 📌 0
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The gut microbiome and multiple sclerosis, using a discordant twin human-mouse transfer model
"Our results implicate two Lachnospiraceae members,
namely Eisenbergiella tayi and Lachnoclostridium, as likely
responsible for an increased incidence of disease."
www.pnas.org/doi/full/10....

21.04.2025 23:15 👍 175 🔁 39 💬 10 📌 5

My talking points in recent interviews, please use as you see fit:
1.Every $1 in NIH funding returns ~$2.50 to the economy.
2.Every $1B in cuts from NIH extramural = 7500 lost employees, just in science.
3.These don't include priceless improvements in health.
1/x

12.03.2025 02:29 👍 168 🔁 77 💬 2 📌 5

🧪

19.11.2024 04:21 👍 7 🔁 2 💬 0 📌 1
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How diet shapes gut microbiota and affects brain function Researchers discuss the diet-microbiota-gut-brain axis, which describes the role of both diet and gut microbiota composition on cognitive and emotional health.

How diet shapes gut microbiota and affects brain function 🍽️🧠🌿 www.news-medical.net/news/2024082... #GutBrainAxis #Microbiota #Diet #Brain #Neuropsychiatry #Cognitive #Health #EmotionalWellness #BrainResearch #MicrobiomeScience #Food #MentalHealth

26.08.2024 21:59 👍 5 🔁 4 💬 0 📌 0


From recruiting the right team to refining our lab’s focus, every day brings something new to learn.

Grateful for the support of colleagues and students as we lay the foundation for impactful microbiome research. Here’s to building a lab that fosters curiosity, collaboration, and growth! 💡🔬

04.11.2024 02:45 👍 0 🔁 0 💬 0 📌 0


🚀 Starting out as a new PI 🚀

It’s been an exciting (and humbling) journey stepping into my role as a new PI! Balancing research goals, teaching, and lab management has been both challenging and rewarding. 1/

#NewPI #ResearchLife #AcademicJourney #MicrobiomeScience

04.11.2024 02:43 👍 2 🔁 0 💬 1 📌 0
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Why deermice do not get sick from Lyme disease Comparing the immune response of deer mice, mice and rats highlights a mechanism by which certain species can tolerate the bacteria responsible for Lyme disease.

Why deermice don’t get sick from Lyme disease. elifesciences.org/digests/9013...

10.01.2024 12:20 👍 5 🔁 5 💬 1 📌 1