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chris macdonald

@ccmm

Postdoc @fraserlab @willowcoyote at UCSF, messing around with proteins. Sentimental empiricist.

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03.07.2023
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Latest posts by chris macdonald @ccmm

didn’t realise it was by mark herman. that boy gets around

07.03.2026 17:12 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
Graph of award probability of R35 and R01 from NIH factbook as a function of review rank percentile. As is apparent, 2025 is a significant departure, with lower award probabilities at all scores <40 and significant departures from norm, where even being in the top 10% is no longer a nearly certain indicator of success.

Data source: https://report.nih.gov/nihdatabook/report/302

Graph of award probability of R35 and R01 from NIH factbook as a function of review rank percentile. As is apparent, 2025 is a significant departure, with lower award probabilities at all scores <40 and significant departures from norm, where even being in the top 10% is no longer a nearly certain indicator of success. Data source: https://report.nih.gov/nihdatabook/report/302

The data is in: the NIH goalposts have shifted.

What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards.

Another manifestation of how HHS policies have led to fewer awards and less science.

07.03.2026 01:59 πŸ‘ 686 πŸ” 420 πŸ’¬ 19 πŸ“Œ 61

gulf strike?

06.03.2026 22:59 πŸ‘ 3 πŸ” 0 πŸ’¬ 2 πŸ“Œ 0
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Have you ever wondered what you would find if you could keep your eyes on a bee for more than a few meters? Us, too!

preprint (with videos!) + thread 🧡

Precise, individualized foraging flights in honey #bees 🐝 revealed by multicopter drone-based tracking

www.biorxiv.org/content/10.6...

1/9

06.12.2025 13:57 πŸ‘ 371 πŸ” 151 πŸ’¬ 9 πŸ“Œ 16
17th century engraving of a capybara under a palm tree eating a banana

17th century engraving of a capybara under a palm tree eating a banana

A break from Christmas content to enjoy this capybara eating a banana. From FranΓ§ois Froger's 'A relation of a voyage ...' (London, 1698).

17.12.2025 09:48 πŸ‘ 561 πŸ” 220 πŸ’¬ 9 πŸ“Œ 18

Organelles do NOT have a single uniform pH.
And if you think they must, because β€œprotons diffuse fast,” this paper is for you.
A thread on why that assumption is wrong; and what we found instead. 🧡 1/n

17.12.2025 00:46 πŸ‘ 518 πŸ” 221 πŸ’¬ 28 πŸ“Œ 31

they’re opening the john jones underground warfare school of excellence soon

04.12.2025 13:25 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

chud ops

04.12.2025 13:12 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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The MAGA meltdown; Mamdani's Rainbow Coalition; Remembering Tatsuya Nakadai Reading, Watching 11.16.25

The weekly Reading, Watching post.β€”
www.unpopularfront.news/p/the-maga-m...

16.11.2025 15:19 πŸ‘ 31 πŸ” 6 πŸ’¬ 2 πŸ“Œ 0
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Agriculture’s new album The Spiritual Sound is available everywhere today.

The record is a study in joy and intensity, carrying forward the ecstatic spirit of their debut while pushing deeper into grief, transcendence, and renewal.

Listen: youtu.be/k9yMIboriEY
@agriculturemusic.bsky.social

03.10.2025 13:15 πŸ‘ 24 πŸ” 2 πŸ’¬ 0 πŸ“Œ 2

try woodman’s before you decide

14.09.2025 03:35 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

toothbrush

11.09.2025 23:23 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

labor discipline

10.09.2025 16:13 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Evolution of polyamine resistance in Staphylococcus aureus through modulation of potassium transport | mSphere Staphylococcus aureus is a leading cause of infectious disease-related deaths globally. Understanding factors that govern adaptation and survival of S. aureus and other pathogens in the host environme...

Excited to share the latest work by outstanding PhD student @kdc509.bsky.social. This was one of our first forays into experimental evolution and uncovered some cool connections between potassium transport and antimicrobial resistance in S. aureus. Major kudos to Killian!

22.08.2025 18:37 πŸ‘ 47 πŸ” 22 πŸ’¬ 4 πŸ“Œ 1
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Quality time in the catio reading & napping

21.08.2025 21:13 πŸ‘ 44 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
a Β½ gallon of neutral milk

a Β½ gallon of neutral milk

They finally made the milk from that hotel

06.07.2025 15:42 πŸ‘ 13487 πŸ” 2571 πŸ’¬ 149 πŸ“Œ 106
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UCSF Asilomar retreat t-shirt, 1990

07.07.2025 12:55 πŸ‘ 36 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

to be fair the vast majority of drug discovery pre-AI has also ended up with toxic compounds

01.07.2025 19:33 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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this whole album smacks of gender

01.07.2025 18:58 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Osmium - Osmium album cover. A kind of runic mark made of 6 double headed fork shapes against a black background.

Osmium - Osmium album cover. A kind of runic mark made of 6 double headed fork shapes against a black background.

Members of #Senyawa and Emptyset join forces with Sam Slater and Oscar-winning composer Hildur GuΓ°nadΓ³ttir for an exploration of machine learning that sounds thrillingly alien

Osmium - Osmium

buff.ly/5jLhEs4
@invadarecords.bsky.social

28.06.2025 13:00 πŸ‘ 23 πŸ” 3 πŸ’¬ 2 πŸ“Œ 2

The diversity subprograms of the primary NIH fellowships were completely terminated, so anyone who submitted one was just rejected instead of being able to transfer to the main one. People people who already had one had it cancelled.

27.06.2025 01:29 πŸ‘ 4 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Adversarial peer review

27.06.2025 01:19 πŸ‘ 4 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

I’m reeling

25.06.2025 07:38 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

In a fugue state years ago I guess I got David Pajo to do a cameo to congratulate me on getting my PhD and I just saw it now

25.06.2025 07:36 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Simplify your life by nondimensionalizing

24.06.2025 08:39 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

I’m patenting a constant anti-unit of temperature called the Bernard. 1 B = 10^30. Then 30 Β°F is just 1.92 B and 100 Β°F is 2.19 B. The beautiful thing is then 1 = 1 B/B.

24.06.2025 08:38 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

One added benefit is that at 1 we have Ξ² = T.

24.06.2025 08:25 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

That’s why I personally get rid of the ambiguity and just have 0 = 0 K and 1 = the Planck temperature. It’s much clearer to have 30Β°F = 1.92*10^-30 and 100Β°F = 2.19*10^-30. Avoids any confusion.

24.06.2025 08:09 πŸ‘ 3 πŸ” 0 πŸ’¬ 1 πŸ“Œ 1

FWIW any openai model I tried seems to be unable to understand the idea

22.06.2025 18:10 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0