Kyle

Tuberculosis Resurgence: A Growing Threat YouTube video by American Society for Microbiology

www.youtube.com/watch?v=QNsl...

4 Months Trapped in a Hospital for an Obsolete Way of Treating Their Disease

Reporting in northern Cameroon, I noticed a few people sitting at the back of a hospital compound. They had drug-resistant TB. They weren't there to get meds or see a doctor: they LIVE there. For months. In isolation. That's government policy. Sanitarium throwback. www.nytimes.com/2026/02/12/h...

I'll second that and add a few more...Christina Stallings, Mary Jackson, Heran Darwin

Over 50 latent tuberculosis cases detected at SF high school amid outbreak Health officials warned physicians to be aware of potential TB symptoms.

www.sfgate.com/bayarea/arti...

Clinical testing of drug treatment shortening in patients with TB using PET/CT imaging of lung lesions Four months instead of the standard 6 months of drug therapy of less extensive tuberculosis disease had a higher risk of relapse.

A shortened, four-month course of tuberculosis drug therapy has a higher risk of relapse linked to active lung cavities compared to a standard 6-month protocol, shows a new #ScienceTranslationalMedicine clinical trial of patients in South Africa and China. https://scim.ag/4jv4oo5

We are hiring new faculty!! Come join our amazing community in the Department of Molecular Microbiology at Washington University School of Medicine! The deadline for applications is 2/21, but applications will be reviewed on a rolling basis. facultyopportunities.wustl.edu/Posting/Deta...

Not saying I'm a fan, but NIH announcement posted does not say peer review is not considered.One of the core tenets of funding decisions is "Prioritize scientific merit; ICOs should consider peer review information in its entirety".

Today @who.int released their 2025 #tuberculosis report, and figures remain unacceptable: 1.2 million children and young adolescents fell ill in 2024, and a staggering 43% were never diagnosed and thus missed lifesaving treatment. Act now to close the deadly gap!

msfaccess.org/msf-responds...

What if NIH had been 40% smaller? Replaying history with less NIH funding shows widespread impacts on drug-linked research

This paper does a great job with a "It's a Wonderful Life" scenario about NIH, supposing the consequences of the bottom 40% of the funding NIH grants never existed.

www.science.org/doi/10.1126/...

tl:dr The world would lose a lot, but directly and indirectly

US lab data show sharp increase in superbug incidence

In 29 states, reporting of carbapenemase-producing carbapenem-resistant Enterobacterales (CP-CRE) clinical cultures rose by 69% from 2019 through 2023.

www.cidrap.umn.edu/a...

Best wishes for your move.

Mining the CD4 antigen repertoire for next-generation tuberculosis vaccines Systematic antigen selection is an enduring challenge in tuberculosis (TB) vaccine development. An antigen screen ranks protective CD4 T cell antigens and yields a novel trivalent mRNA vaccine that protects against TB challenges in mice.

Now online! Mining the CD4 antigen repertoire for next-generation tuberculosis vaccines

TB is the No. 1 killer among infectious diseases. A new study says its toll could mount New research estimates that as many as 2.2 million more people could die of tuberculosis if U.S. cuts to foreign aid become permanent.

New research estimates that as many as 2.2 million more people could die of tuberculosis if U.S. cuts to foreign aid become permanent.

The global return-on-investment of COVID-19 vaccines in the first year of the vaccination programme COVID-19 vaccines played a critical role in reducing global health burden during the COVID-19 pandemic, but their rapid development required extraordinary effort. This study aims to evaluate their glo...

Wow!

Covid vaccine development and delivery cost $79.4 billion, but the health and economic benefits of vaccination were valued between $4.83 trillion–$37.8 trillion.

A return on investment of $59.8–$475 per dollar invested!!

This is why vaccine equity matters!

www.medrxiv.org/content/10.1...

Department members sit at a very long table in the hallway eating a pre-Thanksgiving potluck feast.

Faculty search announcement 2025: Tenure-Track Assistant Professor in Microbiology at UT Southwestern. We seek candidates working in microbial pathogenesis (some preference may be given to bacterial pathogens). Come join our community! (1/5) www.utsouthwestern.edu/departments/...

Curious what led to this discovery....along similar lines, i learned not to assume that all DI H20 is equally suitable for making 7h9 that can grow myco... cost me 6mo as new Asst Prof back in the day

Sterilizing activity of spectinamide MBX-4888A when replacing linezolid in the Nix-TB regimen in the relapsing BALB/c mouse model of tuberculosis https://www.biorxiv.org/content/10.1101/2025.08.04.668403v1

14 Republican senators urge White House to release delayed NIH funds Sen. Katie Britt (R-Ala.) is leading the letter making the ask of OMB director Russ Vought.

14 GOP senators are urging the Trump admin to release stalled NIH funds, warning that delays could shut down life-saving research, cost jobs, and erode public trust in science.

On the line? Real people, real cures, real consequences.

zurl.co/TlewL

Group criticizes NIH over suspended funding for TB research

The Treatment Action Group says the 22 TB projects whose funding was suspended by NIH don't involve "gain-of-function" research.

www.cidrap.umn.edu/t...

11,000 more TB patients died after Trump's USAID cuts. That number will rise. | Opinion The potential for thousands of new deaths from TB is not worth the less than 1% in federal savings that came from cutting USAID.

www.usatoday.com/story/opinio...

We sure are getting back to those good old glory days … of needing tuberculosis clinics

Combating Tuberculosis: Obstacles, Innovations, and the Road Ahead Tuberculosis (TB) remains one of the world’s leading infectious diseases. Every year on March 24th, World Tuberculosis Day is observed, which in 1882 is when Robert Koch announced the discovery of Mycobacterium tuberculosis (Mtb) as the causative agent of TB. This Special Issue features 30 original research articles, perspectives, and reviews from researchers representing 11 countries across all six major continents. ACS Infectious Diseases hopes this special issue encourages our readers to explore the wide range of research showcasing advances in drug discovery and a greater understanding of TB biology.

For the Mtb-focused colleagues, if you haven't seen this issue of ACS Infectious Diseases yet, you can find it here. Lots of good stuff in there.

pubs.acs.org/page/aidcbc/...

Our work estimating the potential impacts of reductions in international donor funding for #TB is now out in @lancetgh.bsky.social:

bit.ly/3TDl28T

@raclark18.bsky.social @cfmcquaid.bsky.social @alexandra-richards.bsky.social @top-j.bsky.social @reinhouben.bsky.social @richardwhite321.bsky.social

The White House Vision for Dismantling Science in One Simple Plot Proposed NIH, NSF, and NASA budgets would be catastrophic for innovation and discovery. But they aren’t reality yet. The time to speak up is now.

The White House Vision for Dismantling Science in One Simple Plot
joshuasweitz.substack.com/p/the-white-... by @joshuasweitz.bsky.social

In 2 trials, less toxic TB antibiotics show promise

The results of two phase 2b trials suggest sutezolid and delpazolid could provide safer alternatives to linezolid in shorter drug regimens for drug-resistant TB.

www.cidrap.umn.edu/t...

BREAKING: Scientists are staging a “science fair” in the lobby of a Congressional building to tell elected officials about the critical knowledge the US will lose because their research grants have been canceled.

Letter urges HHS to convene meeting of advisory group on antimicrobial resistance The letter from the American Society for Microbiology and 40 other groups calls for the President's Advisory Council on Combating Antibiotic Resistant Bacteria to meet 'as soon as possible.'

Letter urges HHS to convene meeting of advisory group on antimicrobial resistance

The letter from the American Society for Microbiology calls for the President's Advisory Council on Combating Antibiotic Resistant Bacteria to meet 'as soon as possible.'

www.cidrap.umn.edu/a...

We set out to quantify U.S. academic contributions to medicines. The results stunned even us From 2020 to 2024, universities contributed patents underpinning 50% of FDA-approved drugs. 87% of those academic breakthroughs came from American institutions.

“universities contributed patents underpinning 50% of FDA-approved drugs…

NIH-funded basic science has contributed to the development of more than 90% of new medicines, vaccines, and devices…

75% of scientists in America were considering leaving the country.”

www.statnews.com/2025/06/06/u...

How about the emails from frontiers with a link you can follow in your free time to find a whole list of pubs to choose from needing reviewers?

TB's extraordinary evolution reveals why the ancient disease lives on Once thought to have originated in cows and spread through dust, the surprising evolutionary story of tuberculosis reveals why it's so hard to stamp out this ancient disease, writes Carl Zimmer

“M. tuberculosis has evolved into an astonishingly adept human pathogen. And one of its greatest skills is its ability to fly through the air”

@carlzimmer.com on why TB has killed millions over the ages

www.newscientist.com/article/2481...