Johannes Brägelmann

Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years?
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...

Wired for growth: neuron–tumour signalling in the lung and brain increases growth of a hard-to-treat cancer Signalling between neurons and tumour cells in the lung and brain promotes the growth of small-cell lung cancer. These interactions might be a therapeutic target.

Signalling between neurons and tumour cells in the lung and brain promotes the growth of small-cell lung cancer

go.nature.com/4gzoMmI

Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer Nature - Basal cells, rather than neuroendocrine cells, have been identified as the probable origin of small cell lung cancer and other neuroendocrine–tuft cancers, explaining...

Super pleased to announce our latest suggesting the cell of origin for #SCLC is most likely the basal cell @nature.com, not the accepted neuroendocrine cell. Implications for the earliest events in cancer, & providing new models of tuft-like cancer.
rdcu.be/eGUtj

Congrats, Trudy & team!!

Neuronal transfer of mitochondria to tumour cells promotes cancer spread Neurons often receive organelles called mitochondria from other cells. It emerges that neurons donate mitochondria that support cancer-cell spread.

Neurons often receive mitochondria from other cells, supporting cancer cell spread

https://go.nature.com/3ZLBhnV

Sure, i meant receiving the offer - that’s already quite a success!

Congrats, Anna!!!! 🥳