Werner Ouwendijk's Avatar

Werner Ouwendijk

@wernerouwendijk

Assistant Professor @ dept. ViroScience, Erasmus MC Herpesviruses and neurodegenerative diseases

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22.11.2024
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Latest posts by Werner Ouwendijk @wernerouwendijk

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Why ‘quantum proteins’ could be the next big thing in biology Nature - Fluorescent proteins with a quantum upgrade could offer unprecedented views inside cells.

Fluorescent proteins with a quantum upgrade could offer unprecedented views inside cells - the next big thing in biology?

go.nature.com/4llx0B5

07.03.2026 11:29 👍 48 🔁 10 💬 1 📌 0
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Vacature: Postdoc Researcher in Molecular Virology of Herpesviruses Herpesviruses are an important cause of severe diseases. Once infected, the virus establishes a lifelong latent infection, which allows it to reactivate later in life. Our team aims to elucidate the v...

We are looking for a postdoc to join our team! Interested in herpesvirus latency? Apply here:

www.werkenbijerasmusmc.nl/en/vacancy/1...

19.02.2026 13:05 👍 1 🔁 3 💬 0 📌 0
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Vacature: Postdoc Researcher in Molecular Virology of Herpesviruses Herpesviruses are an important cause of severe diseases. Once infected, the virus establishes a lifelong latent infection, which allows it to reactivate later in life. Our team aims to elucidate the v...

We are looking for a postdoc to join our team! Interested in herpesvirus latency? Apply here:

www.werkenbijerasmusmc.nl/en/vacancy/1...

19.02.2026 13:05 👍 1 🔁 3 💬 0 📌 0
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@biorxivpreprint.bsky.social EBV reprograms autoreactive anti-CNS B cells as antigen presenting cells in multiple sclerosis
www.biorxiv.org/content/10.6... @stanforduniversity.bsky.social @shady-myounis.bsky.social

14.02.2026 17:41 👍 5 🔁 3 💬 0 📌 0
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Two doses of Recombinant zoster vaccine reduces dementia risk 51% lower risk of dementia (in females > males) even accounting for healthy vacinee bias versus Tdap @natcomms.nature.com
www.nature.com/articles/s41...

09.02.2026 19:06 👍 16 🔁 9 💬 0 📌 0
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ER protein CLCC1 promotes nuclear envelope fusion in herpesviral and host processes - Nature Communications Herpesvirales utilize a unique nuclear egress route for capsid export. Here the authors show that herpesviruses exploit a cellular membrane protein, once thought to transport chloride, to facilitate membrane fusion and egress from the nucleus.

#Virology

Herpesviruses exploit a cellular membrane protein, once thought to transport chloride, to escape the nucleus by tapping into an ancient membrane fusion process

16.01.2026 16:47 👍 27 🔁 16 💬 0 📌 0
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This ‘landmark’ study is now a Version of Record! It shows the #herpes simplex virus-1 uses innovative microscopy and x-ray tomography techniques to examine the roles of 9 proteins in viral formation.
buff.ly/Qn8OXAC

02.01.2026 21:01 👍 9 🔁 3 💬 1 📌 1
eLife Assessment

This important study reports the results of efforts to replicate two phenomena of significant interest to early-career scientists and scientific policymakers: the Matthew effect and the early-career setback effect. Several previous studies of these effects have focused on early-career researchers with grant proposals that fell just below or just above a funding threshold. Those just above the threshold were more likely to be successful when they applied for funding later in the career (an example of the well-known Matthew effect), while those just below were more likely to go on to have stronger publication records (the early-career setback effect). In this study the Matthew effect was found to be robust across funders, and to generalize from those close to the funding threshold to the whole population. The early-career setback effect was not robust across funders and did not generalize to the whole population. The evidence reported is convincing.

eLife Assessment This important study reports the results of efforts to replicate two phenomena of significant interest to early-career scientists and scientific policymakers: the Matthew effect and the early-career setback effect. Several previous studies of these effects have focused on early-career researchers with grant proposals that fell just below or just above a funding threshold. Those just above the threshold were more likely to be successful when they applied for funding later in the career (an example of the well-known Matthew effect), while those just below were more likely to go on to have stronger publication records (the early-career setback effect). In this study the Matthew effect was found to be robust across funders, and to generalize from those close to the funding threshold to the whole population. The early-career setback effect was not robust across funders and did not generalize to the whole population. The evidence reported is convincing.

Evidence from 14 research funding programmes confirms that early winners tend to keep winning (Matthew effect). But the idea that an early setback makes you stronger later doesn’t replicate widely.
buff.ly/UEtcRd4

28.10.2025 21:03 👍 15 🔁 5 💬 0 📌 1
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Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections - npj Vaccines npj Vaccines - Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections

Yes, that would be my best guess. Also based on this follow-up paper:

www.nature.com/articles/s41...

08.10.2025 18:24 👍 0 🔁 0 💬 0 📌 0
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Are Children Receiving Too many Vaccines? Molly Cavanaugh, September 2025 From the time of my birth in 2000 to when I turned 18, I received 55 different shots to prevent 16 different diseases.  Diptheria, tetanus, whooping cough, Haem…

Check out are latest post discussing "Are Children Receiving too Many Vaccines?" virologyunmasked.com/2025/09/29/a...

04.10.2025 15:22 👍 5 🔁 5 💬 0 📌 0
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Multi-proteomic profiling of the varicella-zoster virus–host interface reveals host susceptibilities to severe infection - Nature Microbiology Proteomic characterization of varicella-zoster virus–host protein interactions and infection-induced changes in a neuronal cell line identifies potential targets for drug discovery and molecular insig...

www.nature.com/articles/s41...

Great resource for the VZV community!

26.08.2025 17:33 👍 1 🔁 0 💬 0 📌 0
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Het best werkende middel tegen alzheimer? Een vaccin dat gewoon verkrijgbaar is

Het best werkende middel tegen alzheimer? Een vaccin dat gewoon verkrijgbaar is

28.06.2025 00:10 👍 17 🔁 6 💬 0 📌 2
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Viruses: How herpes is assembled A combination of imaging techniques reveals how herpes simplex virus type 1 assembles within infected cells, highlighting the roles of essential viral proteins in viral assembly and exit.

#Herpes viruses are among the most widespread human viruses. Scientists have shown how HSV-1, known for oral and genital sores, assembles in cells thanks to advanced imaging techniques.

10.05.2025 10:01 👍 4 🔁 2 💬 0 📌 0
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A natural experiment on the effect of herpes zoster vaccination on dementia - Nature Using a natural experiment that avoids common bias concerns, this study finds that the live-attenuated shingles vaccine reduced the probability of a new dementia diagnosis within a follow-up period of...

This is a very exciting study, which suggests that shingles vaccination protects against developing dementia. What could be the underlying mechanisms? Something that we should investigate!

www.nature.com/articles/s41...

03.04.2025 05:19 👍 2 🔁 0 💬 1 📌 0
At least 95% vaccine coverage of 2 doses is needed to stop measles outbreaks.

At least 95% vaccine coverage of 2 doses is needed to stop measles outbreaks.

At least 95% measles vaccine coverage is needed in all communities to prevent #measles and stop outbreaks.

The only way to prevent measles? Two doses of measles vaccine.

Let’s close the gap and keep measles away!

29.03.2025 12:55 👍 1043 🔁 350 💬 13 📌 25
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Anaïs from my team presenting our work on VZV yesterday at the Dutch Annual Virology Symposium #DAVS.

22.03.2025 07:55 👍 3 🔁 0 💬 0 📌 0
Measles is preventable with just two doses of measles vaccine.

Measles is preventable with just two doses of measles vaccine.

The #measles vaccine has saved an estimated 5 lives every second since 2000.

👉Prevent measles by getting vaccinated with two doses of the measles vaccine.

18.03.2025 07:21 👍 2514 🔁 953 💬 32 📌 36
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Defining expansions and perturbations to the RNA polymerase III transcriptome and epitranscriptome by modified direct RNA nanopore sequencing RNA polymerase III (Pol III) transcribes cytosolic transfer RNAs (tRNAs) and other non-coding RNAs (ncRNAs) essential to cellular function. However, many aspects of Pol III transcription and processin...

Our latest preprint is online!

In which we take a left turn and dive head first into the biology of the RNA polymerase III transcriptome and epitranscriptome

Do you want to know more? A small thread follows👇

www.biorxiv.org/content/10.1...

14.03.2025 12:03 👍 9 🔁 2 💬 1 📌 0
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Repression of varicella zoster virus gene expression during quiescent infection in the absence of detectable histone deposition Author summary Varicella zoster virus (VZV) establishes latent infection exclusively in human neurons. This phase of infection is characterized by restricted viral gene expression, lack of detectable ...

Happy to share our publication in #PlosPathogens investigating repression of varicella zoster virus in neuron-like cells: journals.plos.org/plospathogen...
Thanks to @dandepledge.bsky.social and other colleagues for their contribution!

20.02.2025 17:26 👍 10 🔁 3 💬 3 📌 0
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Arts Anthony Fauci: ‘Ik redde miljoenen levens en word toch als vijand gezien’ Anthony Fauci | Arts en immunoloog: Anthony Fauci, vijf jaar geleden het gezicht van de Amerikaanse covidbestrijding, wordt nog altijd met de dood bedreigd door complotdenkers. „Mensen maken op grond…

Anthony Fauci, vijf jaar geleden het gezicht van de Amerikaanse covidbestrijding, wordt nog altijd met de dood bedreigd door complotdenkers. „Ik redde miljoenen levens en word toch als vijand gezien.” https://buff.ly/40Y2Utx

15.02.2025 06:45 👍 66 🔁 11 💬 3 📌 1

First grant application of the year submitted; time for weekend!

14.02.2025 19:44 👍 0 🔁 0 💬 0 📌 0

Time for a fresh start in 2025, so let’s build a new network on this social medium platform - where “social” may actually mean something

15.01.2025 13:52 👍 3 🔁 0 💬 0 📌 0