Coscia Lab

Check out our latest preprint in collaboration with the @garyrlewin.bsky.social lab! We obtained the first subset-specific proteomes of pain sensing neurons!

Excited to introduce openDVP — an open-source framework to bring deep visual proteomics to the broader research community! It includes:
– A simplified fast-track pipeline for easy adoption
– An AI-powered option for advanced image & spatial analysis
👉 BioRxiv: bit.ly/44SBuHu
👉 Github: bit.ly/4eR3IqK

Great work Luke! Any new protocols in our field are helpful to get people started with SP. As you point out, lab specific infrastructure is a very relevant aspect as well. And thanks for the flowers 😅

An ultrasensitive spatial tissue proteomics workflow exceeding 100 proteomes per day Achieving high-resolution spatial tissue proteomes requires careful balancing and integration of optimized sample processing, chromatography, and MS acquisition. Here, we present an advanced cellenONE...

Thrilled to share our latest preprint describing an optimized spatial tissue proteomics workflow for the preparation and analysis of >100 proteomes / day at high spatial resolution.
Kudos to @melissaklingeberg.bsky.social 🥳 and big thanks to all our collaborators! bit.ly/3SCARw4

Deep spatial proteomics of ovarian cancer precursor lesions delineates early disease changes and cell-of-origin signatures High-grade serous ovarian cancer (HGSOC) is a devastating disease that is frequently detected at an advanced and incurable stage. Advances in ultrasensitive mass spectrometry-based spatial proteomics ...

Our lab's newest preprint is out on deep spatial proteomics of ovarian cancer precursor lesions!
We demonstrate how ultrasensitive discovery proteomics can shed light onto early carcinogenesis, uncover cell-of-origin signatures, and prioritize novel drug targets.
bit.ly/41M7fke

Shout out to the organisers @jesperolsenlab.bsky.social, (Tina Ludwig) @baybioms.bsky.social kathrynslilley.bsky.social, Caroline May and Britta Eggers
and the speakers @bonalditiziana.bsky.social, @coscialab.bsky.social, @kusterlab.bsky.social, @anamdv.bsky.social, @jsandow.bsky.social

Our selected speakers doe rhe different sessions are:
Georg Kustacher - bioinformatics
@coscialab.bsky.social single cell/spatial session
Manuel Mayr - clinical proteomics
Richard Seltema - structural
Freddie Theodolou - non-human proteomics
Jyoti Choudary - functional proteomics

ISCO - ISCO

"Innovations in Single Cell Omics" Berlin 5.12-13.
Keynote Speakers:
@shalinhnaik.bsky.social
Pulin Li, and me!
Invited Speakers:
@emmanuel-saliba.bsky.social
@mratz.bsky.social
Barbara Grünwald
Maria Colomé-Tatché
Mohammad Lotfollahi
@coscialab.bsky.social
Teresa Krieger
www.isco-conference.eu

Wonderful group dinner tonight, #proudPImoment ☺️🫶

Next up at the @fogenomics.bsky.social proteomics stage, @ajbrenes.com talking about single-cell proteomics applied to neutrophils. Cool stuff!

Thanks Alastair! :-)

Extremely happy that our Deep Visual Proteomics pipeline is one of the highlighted @naturemethods.bsky.social Spatial Proteomics approaches! 🥳 Congrats to the growing DVP team(s)! Making it broadly accessible & advancing it to the multiomics space is a key mission in our lab @mdc-berlin.bsky.social