Zoran Paunic

It would be interesting to do such a study, but only in ESKD patients with a residual diuresis of at least 300 ml.

PET images of adrenals

An aldosterone synthase (CYP11B2 enzyme)–specific 18F-labeled radioligand to help lateralize in PA

www.nejm.org/doi/full/10....

very cool science and technology

Any comments from the Aldo experts? @anandvaidya17.bsky.social

#NephSky #EndoSky

It seems to be a recurring problem, though. As you can see from the link above, Science's team found that several of these clinical centers have previously fouled up trial data for other companies and other drugs, and that alone should make any responsible CRO avoid them like radioactive waste zones. But the problems are even deeper. It appears that many of these Miami-area centers are cheerfully enrolling "professional patients" who are signing up for as many trials as possible to collect the payments and benefits, and who are likely as not throwing the pills themselves away. By this point in the article, my head was in my hands, and I'm sure that's a common reaction. This sort of idiotic fraud is the exact opposite of medical research.

Remember the TOPCAT story of what happened in Russia and Georgia?

This is worse: www.science.org/content/blog...

And in South Florida.

From @dereklowe.bsky.social

Comparison of pulse and oral steroid in childhood membranoproliferative glomerulonephritis - PubMed Pulse MP therapy may be superior to oral P therapy in children with MPGN in preserving renal function without any increase in steroid-related side effects. Chronic damage in the presentation biopsy and lack of remission of NS are adverse features.

I don’t know about the quality of this trial, I’ve found just the abstract.

pubmed.ncbi.nlm.nih.gov/17514629/

Hepatic Encephalopathy with healthy liver?

🤔Pt with cognitive impairment, - neuro workup. Discharged with diagnosis of dementia, focal seizures.

👍CT lge intrahepatic portovenous shunt; Ammonia 🔼

😀Improved with PSE Rx, ultimately treated in IR

Sort of a congenital TIPS

#IMsky #GIsky #Medsky

Excellent study with positive results, let's hope another study confirms this.

Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis | New England Journal of Medicine

meet me at #ESOTcongress in London 🇬🇧

🗓️ July 1, 13:00-14:00, ROOM s5

to discuss Torque Teno virus 🦠 based immunologic monotoring

viruses 🦠 can be superheroes 🦸

#ESOT2025 #TTVguide #ESOT

Loop Diuretics in Anuric Hemodialysis Patients for the Clearance of Protein-Bound Uremic Toxins AbstractBackground. In chronic kidney disease (CKD), the accumulation of protein-bound uremic toxins (PBUT), such as hippuric acid, p-cresyl sulfate, and i

An interesting pilot study: a regular dose of loop diuretic enhances hemodialysis clearance of protein-bound uremic toxins in anuric patients. academic.oup.com/ckj/advance-...

Furosemide and Serum Protein-Bound Uraemic Toxin Concentrations in Patients with Chronic Kidney Disease Furosemide is commonly prescribed to patients with CKD but may impair the kidney’s excretion of protein-bound uraemic toxins (PBUTs) via the organic anion transporters 1 and 3 (OAT1/OAT3). We evaluate...

In CKD, furosemide use—especially >100 mg/day—is linked to higher serum levels of protein-bound uraemic toxins like IS, PCS, Kyn, and IAA. Furosemide may impair toxin clearance via OAT1/3 transporters, contributing to toxin accumulation.
#podoctyetalk #CKD #Nephsky
www.kireports.org/article/S246...

Does Iodinated Contrast Affect Residual Renal Function in Dialysis Patients? A Systematic Review and Meta-Analysis - PubMed Intravascularly administered contrast media may not result in a significant reduction of residual function in dialysis patients.

We pooled all the (suboptimal data) together in this meta-analysis pubmed.ncbi.nlm.nih.gov/32155642/

Hardly any effect on residual function

Transmission of tuberculosis via #kidneyallograft

Renal allograft-transmitted #tuberculosis is a rare and potentially fatal infection in the early post-transplant period.

doi.org/10.1016/j.kint.2024.08.011

#KINephrologyImage #kidneytransplantation #MedSky #NephSky

A retrospective study from Taiwan: ESA vs w/o ESA in CKD and ESKD patients:
HR for incident malignancy 1.84 with ESA; for genitourinary malignancy 12.55.
The risk was positively correlated with the cumulative dose of ESA.

doi: 10.1111/cts.13353

Check out this special collection that highlights the clinical connection between disorders of the kidneys and the heart:

https://bit.ly/3AVbArF

#Cardiorenal