Audrey Denizot

Job alert! 🚨 We are recruiting an engineer to implement an open-source data hub of 3D cell reconstructions and meshes! More details here: lnkd.in/dq4sHRuC. Please reach out with a one page statement presenting your interests & a resume if interested #job #research #compneuro #engineer #neuroscience

Excited to share our new preprint! We explore the link between the locus coeruleus (LC) and arousal for astrocytes, pyramidal cells, interneurons in the hippocampus. A fantastic collaboration with @sianduss.bsky.social @bohaceklab.bsky.social, and many others: www.biorxiv.org/content/10.6... 1/5

Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry Dereddi, Djannatian, and colleagues show that oligodendrocytes use mechanical cues to measure axon size. The stretch-activated channel TMEM63A converts membrane tension into calcium signals, which cal...

We identified how mechanical forces shape myelin development. The TMEM63A channel in oligodendrocytes converts physical cues into molecular signals that control myelin growth.

Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry: Neuron www.cell.com/neuron/fullt...

👉🏼👉🏾👉🏻👉🏿👉🏽An opportunity for a PhD studentship in my lab to investigate the mechanisms that mediate the specialization astrocyte endfeet (subcellular compartments enwrapping the vasculature) in collaboration with the magnificent Lorena Arancibia.

See below:

3D meshes from the study: zenodo.org/records/1710... ; code: github.com/adenizot/PAP... ; full-text: hal.science/hal-03591633/ #GliaPapers #astrocytes #glia #modeling #compneuro #neuroscience

Thrilled to announce that our study with C. Calı̀, Marifer Veloz, P. Puchenkov & @deschutteroist.bsky.social is out in #Glia! We explored the properties of the intracellular organization of astrocytes and how the latter influences astrocyte function at their interface with neurons 💫 bit.ly/4ql73Ul

Want to know how endoplasmic reticulum (ER) spatial structure affects calcium signaling in astrocytes? Check our new paper now online in Glia. The placement of IP3 receptors is crucial to determine whether ER close to the membrane amplifies calcium signals. onlinelibrary.wiley.com/doi/10.1002/...

Just out in Nature! “The astrocytic ensemble acts as a multiday trace to stabilize memory.” We identified astrocytic ensembles that link experiences across days to stabilize memory nature.com/articles/s41.... New astrocyte tools are openly available at Addgene: addgene.org/Jun_Nagai/. 1/8

Curious about the use of PDE discovery methods for mecanistic multiscale models of cell signaling? Check out our new benchmark paper, work by our amazing PhD student Andréa Ducos: hal.science/hal-05128224 First joint paper with @thomas-guyet.bsky.social! #modeling #PDEs #multiscale #cells #signaling

Sharmila Venugopal and I are delighted to co-edit a collection of video articles showcasing advances in computational neuroscience methods & software. There is still time to submit an abstract! More details here: app.jove.com/methods-coll...
#compneuro #neuroscience #neuroinformatics #OpenScience

Big week for astrocyte research: 3 new Science papers link astrocytes to behavior. We're excited to add to the momentum with our new PNAS paper: a theory, grounded in biology, proposing astrocytes as key players in memory storage and recall. w/ JJ Slotine and @krotov.bsky.social
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Marseille is calling! 🇫🇷🌊☀️
Join us at #GLIA2025, where cutting-edge science on #glia cells meets the charm of the French Mediterranean.
📍 Marseille | 8–11 July 2025
🎥 Watch the GIF & get a taste of Marseille’s vibrant energy!
🌐 Register here: glia2025.eu

Revised preprint out! www.biorxiv.org/content/10.1... We show that most perisynaptic astrocytic processes contain calcium stores and identify the ultrastructural properties of the ER as key regulators of astrocyte function. With C. Calı̀, Marifer Veloz, P. Puchenkov & @deschutteroist.bsky.social

✨ Announcing a new glutamate indicator - iGluSnFR4! ✨

Launched as a pair, iGLuSnFR4s and iGluSnFR4f have high-sensitivity and fast activation/deactivation for recording synapses.

More on the indicators and what they are already revealing: www.biorxiv.org/content/10.1...

🧠📈

Looking forward to this outstanding workshop on neural computation without neurons ⭐ Looking forward to presenting some new unpublished data on the influence of astrocyte ultrastructure on their function at the nanoscale in health and in #Alzheimer's disease. Extremely grateful for the invitation!

Applications are now open! 3-week courses: Comp Neuro and Deep Learning. 2-week courses: NeuroAI and Comp Tools for Climate Science.

🚨 Neuromatch Academy Course Applications are OPEN for 2025!! 🚨

Get your application in early to be a student or teaching assistant for this year’s courses!

Applications are due Sunday, March 23.

Apply & learn more: neuromatch.io/courses/

#mlsky #compneurosky #ai #climatesolutions #ScienceEdu 🧪

Early-life stress induces persistent astrocyte dysfunction associated with fear generalisation Amygdala astrocytes play a critical role in mediating the effects of stress during infancy on neuronal excitability, synaptic plasticity, and memory.

Version of Record of our work at @elife.bsky.social has been published! Super proud of this one after all the hard work of the lab seeing it to the end.

Make sure to click through figure supplements as there is so much good stuff in there - sex differences, etc.

elifesciences.org/articles/99988

Le Congrès Européen « XVII European Meeting on Glial Cells in Health and Disease » aura lieu à Marseille du 7 au 11 Juillet 2025.

Le comité d’organisation lance un appel à candidature pour 10 volontaires pour une aide logistique lors du meeting !!
Date limite : 8 février 2025
frenchglialcellclub.fr