Warm congratulations to The Brain Prize winners 2026, Professor David Ginty and Professor Patrik Ernfors, for their pioneering work on how the nervous system detects and processes touch and pain.
Karolinska Institutet
HHMI
#Neuroscience #BrainPrize2026
A new preprint introduces aDISCO, a DISCO-based clearing approach that makes whole archival FFPE human tissues transparent and antibody-compatible, enabling true 3D light-sheet histology across brain & multiple organs at cellular resolution. Aguzzi & Helmchen teams.
www.biorxiv.org/content/10.1...
Our review “A competition model of multilineage priming and cell-fate decisions” is out: www.cell.com/cell-reports...
In @elife.bsky.social: A high-resolution, easy-to-build light-sheet microscope for subcellular imaging doi.org/10.7554/eLif...
Professor Leszek Kaczmarek, who supervised and kindly supported me while I was in Poland, offers his candid opinion on the advantages and challenges of pursuing a researcher career in Poland.
New on bioRxiv! 🚨
“Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature”
This project studying #microvascular cells took an unexpected turn when we discovered that #pericytes have primary #cilia!
🔗 www.biorxiv.org/content/10.1...
🧪 🧵1/8
#LISH25 was BIG.
This was FUN! Thanks everyone. Light sheet fever. #LISH25
Huge thanks to @paveltomancak.bsky.social and @embo.org for hosting this year's amazing Light Sheet Microscopy course #LISH25. Our @dvonwangenheim.bsky.social and team were thrilled to capture beautiful images of many samples with AxL Cleared Tissue LightSheet 🔬
🌍 www.intelligent-imaging.com/AxL
Thank you @paveltomancak.bsky.social @olafselchow.bsky.social @dvonwangenheim.bsky.social @bundschuhst.bsky.social @ereynaud.bsky.social @cuencam15.bsky.social Vlado, Stephan for a life-changing lightsheet experience towards even more beautiful and high-quality science
Walking into the brain of an Alzheimer’s mouse. I overloaded the mouse with therapeutics (pink) and labeled vessels (green), and was clearing the brain for almost 2 months. Thanks to Stephan for a nice movie from #Blaze microscope at #LISH25 #LISH2025
It was such a lovely (though a bit tough) experience for me! Thanks to the organiser @paveltomancak.bsky.social for the inspiration for this long trip (even if it was the “minimal version”) and for another great day at #LISH25.
Love these names 😆
An AD mouse brain with therapeutic antibody (in blue) and smooth muscle cells (in yellow).The first attempt, but quite successful. Thanks to @dvonwangenheim.bsky.social
#LISH25
The world behind LS7 and Blaze starts with 3i for me. Very excited to see the result of an overnight imaging #LISH5 #AD #neuroscience
My tutorial materials & slides about #Reproducible #BioImageAnalysis using Python, Napari, Jupyter and #AI are available #openaccess.
Thanks to #EMBOlsm25 for having me! It so great to visit friends at my former academic home campus for a couple of days 🤩
scads.github.io/embo-lsm-bia...
We teach also #Napari at #LISH25. By @haesleinhuepf.bsky.social highlighting the awesome power of #Jupyter_notebooks for #reproducibility
It has been an amazing day#1 of the Light Sheet Microscopy Course #LISH25 in Dresden; excited to look at the microscopy world beyond Blaze and Light sheet 7
Congratulations! 👏 Wishing for a smooth publishing process!
Excited to present our study in @natneuro.nature.com: a deep brain pathway that triggers safety-driven movement—overriding needs like finding food or social contacts. A look into how the brain weighs deep instincts. Congrats to all and first author @nkrauth.bsky.social. shorturl.at/toYFN
Your brain functions not only as a thinking organ but also as a miniature water factory. We here calculate how much water neuronal mitochondria produce by glucose oxidation: 300-400 ml. Of that amount, 100 ml go into brain's interstitial fluid. fluidsbarrierscns.biomedcentral.com/articles/10....
