Yash Gupta PhD

Stanley Park, Vancouver, BC, Canada.

Sunset over the bay in Stanley Park

Along the walking trail in Stanley Park

Autumn beckons in Vancouver, British Columbia.

O’ Canada….we pledge our hearts to thee.….especially in #Autumn in Vancouver, British Columbia in Stanley Park. A reflection of colors for the #BlueSkyArtShow.

#photography
#urbanphotography
#landscapephotography
#britishcolumbia
#canada
#nature

This study presents a novel biomimetic nanoparticle platform—Caco-2 cell membrane-coated, manganese-doped ZnO nanorods—for targeted microRNA (miR-200c-3p) delivery to intestinal epithelial cells. By combining magnetic responsiveness, homotypic targeting, and lipid membrane camouflage, the engineered nanoparticles achieve site-specific delivery, enhance intestinal permeability, and modulate tight junction integrity without inducing toxicity. The work demonstrates, for the first time, that: miRNA-loaded nanorods can be guided magnetically and penetrate the mucus barrier. Homotypic targeting using epithelial cell membranes improves localization and uptake. miR-200c delivery via this platform significantly alters occludin expression and gut permeability in vivo. This approach opens new avenues for precision therapeutics in IBD and barrier dysfunction disorders, offering a biocompatible, traceable, and customizable delivery system for gut-targeted RNA therapies.

🚀 New in @SciReports:
Biomimetic ZnO nanorods camouflaged with Caco-2 membranes enable targeted miRNA-200c delivery to gut epithelium.
🔗 doi.org/10.1038/s415...
#MicroRNA #Nanomedicine #IBD #DrugDelivery #Biomaterials #GutHealth #RNAtherapeutics #Nanoparticles #GIbarrier #PrecisionMedicine

Medical Bills Are Like: Room and Board: $35,451 Accessing Healthcare Free: $4,543 Pharmacy: $8,543 Might As Well Charge You This Fee: $3,121 Laboratory: $5,432 Soap and Washcloth: $564 Printing out this medical bill fee: $9,871 Ibprofen: $321 Fee fi fo fum fee: $5,465 processing fee: $3,235 Another dollar won't hurt fee: $1 What the f ck u gonna do about this: $345 an extra fee fee: $543 asking the nurse questions fee: $2,676 Making eye contact with doctor fee: $6,565 We didn't kill you this time fee: $876

A recent study developed 125 eDNA-based qPCR assays (markers) to detect species of conservation relevance across North America from fish to frogs to birds using just traces of DNA in the air, water or soil. You can now study animals without even seeing them. doi.org/10.1002/edn3...

#booksky

Seed-borne bacteria drive wheat rhizosphere microbiome assembly via niche partitioning and facilitation - Nature Microbiology A sequential propagation strategy shows how the microbes initially on seeds are key to building complex, reproducible and heritable plant microbiomes.

Wow! Our paper in @natmicrobiol.nature.com has just surpassed 10,000 views in less than a month!! a rare feat for a #plant #microbiome study! We argue that seed-borne bacteria are the architects of the wheat rhizobiome. Thanks to everyone who’s been engaging with our work :) doi.org/10.1038/s415...

Antibiotic-induced gut #microbiome perturbation alters the immune responses to the rabies #vaccine.

Gut microbiome disruption skews the Th1/Tfh balance to primary #rabies vaccination.

www.cell.com/cell-host-mi... #MicroSky

HiBC: a publicly available collection of bacterial strains isolated from the human gut - Nature Communications Here, the authors present and characterise a collection of human gut bacteria including novel taxa associated with health conditions and a large diversity of plasmids. All isolates, their genomes and ...

A GO for studying the microbiology of the human #Microbiome!

Congrats @tclavel.bsky.social, Tom’s team and collaborators.

www.nature.com/articles/s41...

🚨 Over half the world has H. pylori — but there’s good news!

▶️ Adding Saccharomyces boulardii to bismuth quadruple therapy boosts eradication rates and slashes side effects

🔬 Meta-analysis of 10 RCTs

🔗 bmcgastroenterol.biomedcentral.com/articles/10....

🌐 #GutHealth #Probiotics #Microbiome #INPST