Jaehyuk Choi

Congratulations!

Good news keeps coming! Excited to share our latest preprint expanding myeloid cell editing capabilities: Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells, led by Hyuncheol Jung and Pascal Devant joint with @juliacarnevale.bsky.social

We have an active search for tenure-track faculty interested in #ImmuneEngineering #ProteinEngineering #GenomeEngineering & #CancerImmunology. Join the newly formed Center for Cellular Therapies and Cancer Immunology #CCTCI. Learn more at apply.interfolio.com/173562. #facultyjobs

People With Severe Diabetes Are Cured in Small Trial of New Drug

Wow!!! 👏👏👏 Amazing to see this develop over the years!

www.nytimes.com/2025/06/20/h...

Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer’s disease - Nature Cell Biology Chou et al. generate transdifferentiated human neurons from fibroblasts from young or aged individuals and patients with Alzheimer’s disease. Studies of endolysosomes and proteostasis suggest a role f...

☕Have you read this study from our journal (@naturecellbiology.bsky.social) yet?
Studies of endolysosomes and #proteostasis suggest a role for lysosomal quality control in #Alzheimers disease pathology.
bit.ly/4lSORPV

Ohio Medicaid got rid of big middlemen. Says it paid pharmacies a lot more — and saved $140M • Ohio Capital Journal The Ohio Department of Medicaid department in 2022 gave powerful prescription drug middlemen the boot and created a new system. The result: Fees paid to pharmacies were boosted more than 1,200% while ...

Ohio Medicaid got rid of big middlemen. Says it paid pharmacies a lot more — and saved $140M ohiocapitaljournal.com/2025/04/17/o...

some GD T cell lymphomas are addicted to JAK-STAT signaling and relapse with new JAK-STAT mutations, much like melanomas to BRAF inhibitors. ? new approach ? to treating these aggressive diseases. cell of origin (GD cells) important but unclear why. stay tuned for more.
www.jci.org/articles/vie...

DNMT1 inhibition reprograms T cells to NK-like cells with potent antitumor activity www.science.org/doi/10.1126...

Review @jimmunol.bsky.social
Can autoimmune disease be cured by deep CD19+ cell depletion?
doi.org/10.1093/jimm...

Cas12a-knock-in mice for multiplexed genome editing, disease modelling and immune-cell engineering
www.nature.com/articles/s41...

Experimental brain tumor treatment shows promise for pediatric brain cancer Gavin Nielsen, who was 2 years old when he was diagnosed with a rare brain cancer, met Dr. Nicholas Vitanza who is part of a growing group of researchers exploring CAR-T therapy. The treatment program...

Thanks to Dr. Syal & @nbcnews.com for visiting our #CARTcell program to highlight one of our courageous little patients with #DIPG #DMG. So much work left to do but thankful for the support of Seattle Children’s and our brave families. ❤️

www.nbcnews.com/now/video/ex...

AGO2 mediates immunotherapy failure via suppressing tumor IFN-gamma response-dependent CD8+ T cell immunity
www.cell.com/cell-reports...
@cp-cellreports.bsky.social

Dynamic STING repression orchestrates immune cell development and function Repression of STING expression in neutrophils and T lymphocytes is required for immune homeostasis and tumor response.

New #ScienceImmunology research involving mice and human tissues demonstrates how different immune cell types modify expression of stimulator of interferon genes (STING) to support their normal development and function. scim.ag/4idx7wn

How does sleep protect against neurodegenerative disease? A review, open-access
www.cell.com/neuron/fullt...

Congratulations! Great talk at keystone

Regulatory T cells with engineered specificity for HLA-DQ2.5–restricted deamidated gluten peptides exert bystander suppression in vivo
www.science.org/doi/10.1126/...

VDAC2 loss elicits tumour destruction and inflammation for cancer therapy - Nature VDAC2 deficiency elicits uncontrolled IFNγ-induced BAK activation and mitochondrial damage for improved cancer therapy.

⁦‪#InterferonPower! Hongbo Chi‬⁩ &co @stjude.bsky.social @stjuderesearch.bsky.social show ⁦‪@nature.com‬⁩ that VDAC2 deficiency facilitates tumor destruction by T cell-driven IFNgamma by causing mitochondrial (mt) damage & mtDNA sensing by cGAS–STING, which drives type I IFNs & tumor death!

Congratulations!

#ScienceSaturday 🧵

❓ Are B cells important to eliminate cancers? T cells, capable of directly killing cancers, have been widely studied in tumor immunology.

🎉 Congratulations 🥳 to our Director, @miriammerad.bsky.social, on winning this year’s Sjöberg Prize! Check out the video announcement below 🔽

Review @nature.com @quintanalab.bsky.social
The neuroimmune connectome in health and disease
www.nature.com/articles/s41...

Repair Drive enables in vivo expansion of gene-targeted hepatocytes in adult mice
www.science.org/doi/10.1126/...

PD-L1 from tumor extracellular vesicles induces T cell senescence through lipid metabolism
www.science.org/doi/10.1126/...

In chaotic times, it is important to emphasize how much i appreciate my fellow scientists and the science they do. Inspired countless times each day by my colleagues in the field.

The best part of science for me is when someone in the lab or a former lab member has awesome new data and rushes to share it. everything else pales in comparison.

Going post new things here and not on X. Will be focused on science/career development and drug development, with the occasional sports (Mets, Knicks, hockey) tweet..

Grants should focus more on the person/people doing the science>>the specific experimental minutae. Flexibility to follow the path the data illuminates>>>milestones and deliverables.

Protein codes promote selective subcellular compartmentalization Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...

Cool paper using LLM to discover a protein sequence code for subcellular localization 👏

www.science.org/doi/10.1126/...

I believe that most of our society values science and scientists. We need to continue to communicate our findings and value to the public and advocate for increased research funding, especially for young investigators->they are the future.