Paulina Strzyz

The Other Side of the Desk: Science Editors and Submissions The Academic Life newsletter by Christina Gessler, Ph.D.

Ever wondered what a scientific editor actually does? I recently shared my perspective on this in a written interview for the Academic Life Substack:
👇
shorturl.at/vqGxU

#CareersOutsideAcademia #ScientificEditing #AdvancedScience

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53 NUMB Ex3-containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells an...

New in #AdvancedScience @wileylifesci.bsky.social
Cells can export the tumor suppressor #p53 in #exosomes and share it with neighbors. The transferred p53 remains functional—activating protective programs in recipient cells.
In this way cells might collaborate to prevent cancer.
📄 shorturl.at/veeKj

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid-beta and phospho-Tau aggregation, neuronal hyperexcitab...

New in #AdvancedScience @wileylifesci.bsky.social
Human brain #organoids from #Alzheimer's patients now faithfully reproduce disease pathology. Even better: a new #autophagy drug candidate reverses the damage.
A step toward testing treatments in human tissue, not just mice
📃https://shorturl.at/HvAKn

Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic Proteins Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor-dependent transcriptional and translational mechanisms. VitD regulates ....

#VitaminD does more than support bones—it fine-tunes sense of #smell! New work in #AdvancedScience @wileylifesci.bsky.social shows vitamin D controls synaptic proteins in the olfactory bulb, using both gene regulation and #mTOR. Nutrition meets #neuroscience!
🔗 shorturl.at/3ubBn
#Olfaction

TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane-anchored LC3 partitions into these condensates, suggesting that...

New research in #AdvancedScience @wileylifesci.bsky.social TBK1 phosphorylation drives optineurin to form filaments that phase separate with poly #ubiquitin and LC3, organizing cargo for selective #autophagy. New insight into autophagy and #neurodegeneration.
🔗 shorturl.at/HzkK8

Brillouin Microscopy of Breast tumor Spheroids On‐a‐Chip: Mechanical and Transcriptional Responses to Microfluidic‐Induced Rapid Deformations Brillouin-Raman Microspectroscopy on-a-Chip (BRmS) enables real-time analysis of breast tumor spheroids in microfluidic channels. Following cyclical deformations, MCF10.DCIS.com spheroids are capture...

New in Advanced Science: Brillouin–Raman microscopy on-a-chip reveals how mechanical stress rewires breast tumor spheroids—boosting ATF3 and invasion. New tool for cancer mechanobiology.
🔗 doi.org/10.1002/advs...
#cancer #mechanobiology #biophotonics @wileylifesci.bsky.social @lab-scita.bsky.social

The Importance of Being Imperfect: Structure and Function of Bacterial Amyloid Functional bacterial amyloids such as CsgA and FapC have been widely studied to understand the relationship between aggregation and function. The recently solved structure of FapC reveals a Greek-key...

New review in #AdvancedScience: #Amyloids aren’t just disease markers—in bacteria, they’re dynamic, functional protein assemblies with roles in biofilms, catalysis, and more. Ripe for #biomaterials innovation!
🔗 shorturl.at/wPAQb
#microbiology #SyntheticBiology @wileylifesci.bsky.social

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses Cryopreserved lung-humanized mice overcome the dependency to fresh tissues and permit head-to-head profiling of all four human common cold coronaviruses versus SARS-CoV-2 infection; the model validat...

New in #AdvancedScience: Dual-humanized mouse model with cryopreserved human lung tissue lets researchers study common cold #coronaviruses & #SARS-CoV-2 in a human-relevant way. Opens doors for testing #antivirals and exploring immune responses.
🔗 shorturl.at/CYJZU @wileylifesci.bsky.social

New in #AdvancedScience @wileylifesci.bsky.social : Zhang et al. reveal how ERK, PKA, YAP/TAZ & SHH signaling shape cortical radial glia fate—offering fresh insight into brain development and evolution. #Neuroscience #RadialGlia #BrainScience #BrainEvolution shorturl.at/Z0isZ

Extracellular Matrix Viscoelasticity Regulates Mammary Branching Morphogenesis This study shows that mammary branching morphogenesis is regulated by extracellular matrix (ECM) stress relaxation. Slow stress-relaxing matrices promote branching through focal adhesion signaling, c...

New work in #AdvancedScience Extracellular Matrix Viscoelasticity Regulates Mammary Branching Morphogenesis @ucsantabarbara.bsky.social #Morphogenesis #ECM #Biomaterials #TissueEngineering #CellBiology #Mechanobiology Read full OA article shorturl.at/RxQIh

Nanoscale Mapping of the Subcellular Glycosylation Landscape Using multiplexed super-resolution imaging with fluorophore-labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending ...

Glyco-STORM: Nanoscale Mapping of the Subcellular Glycosylation Landscape by @majaklevanski.bsky.social published in #AdvancedScience Read full OA article here: shorturl.at/4GvlM @wileylifesci.bsky.social

Phospho-eIF2B-epsilon links stress response-driven translation to amyloidogenesis in Alzheimer's disease https://www.biorxiv.org/content/10.1101/2025.11.03.686297v1

Multiple oestradiol functions inhibit ferroptosis and acute kidney injury - Nature 17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules.

Happy to start at Bluesky with a post on our recent manuscript at @nature.com:

www.nature.com/articles/s41...

Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.

Secondary Necrosis Following Caspase‐Activation can Occur Independently of Gasdermin E Secondary necrosis follows apoptosis, but its mechanism is unclear. This study shows that although gasdermin E is cleaved during this process, it is not required for membrane rupture. Across multiple...

🧬 Just published in Advanced Science: New work from @linkermannlab.bsky.social showing that secondary necrosis can occur without Gasdermin E. A clear step forward in decoding regulated necrosis. #CellDeath #SecondaryNecrosis #GSDME #CaspaseInhibition #AdvancedScience #EditorPick shorturl.at/ITJe6

Organization of the Proteostasis Network of Membraneless Organelles A comprehensive mapping of the proteostasis network (PN) across membraneless organelles (MLOs) reveals how central PN components coordinate MLO regulation. The analysis uncovers principles of specifi...

New in Advanced Science: Cells regulate membraneless organelles using a shared proteostasis network. HSP70 chaperones act broadly, while co-chaperones provide organelle-specific control.
Vendruscolo-Morimoto labs collaboration
🔗 shorturl.at/v0TeH
#Proteostasis #MembranelessOrganelles

Apoptotic Vesicles Derived from Mesenchymal Stem Cells Ameliorate Hypersensitivity Responses via Inducing CD8+ T Cells Apoptosis with Calcium Overload and Mitochondrial Dysfunction The therapeutic potential of ApoVs derived from stem cells from human exfoliated deciduous teeth (SHED-ApoVs) in the treatment of CD8+ T cell-mediated hypersensitivity reactions is noteworthy. SHED-A...

New in Advanced Science: Apoptotic vesicles from mesenchymal stem cells selectively induce CD8⁺ T cell apoptosis via calcium overload—offering a novel strategy to treat type IV hypersensitivity
#Immunotherapy #ExtracellularVesicles #Nanomedicine #CD8Tcells #Hypersensitivity
🔗 doi.org/10.1002/advs...

Don't miss this fantastic #Review! I still feel partly responsible, having commissioned it ;) ❤️nrmcb!

Nuclear pore permeability and fluid flow are modulated by its dilation state Hoffmann et al. describe within cells how the Dictyostelium discoideum nuclear pore complex structure constricts and dilates as a consequence of osmotic stress. Based on their experimental findings, they propose a hydrodynamics model and quantify fluid flow across nuclear pore complexes under conditions when nuclei change their volume rapidly.

Exciting work by Martin Beck’s group @mpibp.bsky.social providing further evidence for nuclear pores responding to mechanical stress. The work includes some nice modeling estimating the fluid flow across nuclear pores as a function of (osmotic) pressure.
www.cell.com/molecular-ce...

Stoked to share TWO preprints on mitochondrial pearling! 🎉
We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and
@gavsturm.bsky.social
et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪

Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology

www.biorxiv.org/content/10.1...

Amazing initiative for peer-reviewing and curating preprints: noteforms.com/forms/dsdc-p.... Currently trialling in cancer and immunology.

Congrats @marija-matejcic.bsky.social for a killer talk at the ASCB #CellBio2024 👏 #Mechanobiology 4eva