ImmunoPasteur

NK immune cells learn to fight against bacteria Natural killer (NK) cells are part of the innate immune system, our first line of defense. We already know that they can develop immune memory after infection with Streptococcus pneumoniae. More recen...

NK cells have immune memory against bacteria 🦠

Previously thought to lack learning ability, natural killer cells reprogram after pneumococcal infection.

New prospects for antibacterial immunotherapy.

Straight talk from Institut Pasteur 🧪

What if the immune system held a key to brain health ? 🧠

Research by Aleksandra Deczkowska @adeczkowska.bsky.social at the Institut Pasteur shows constant immune–brain dialogue, and how modulating immunity could help prevent or treat neurological diseases.

Environmentally driven immune imprinting protects against allergy - Nature In a mouse model, environmental immunostimulation in early life led to cross-reactive adaptive immune memory and reduced type II immune responses to allergens, indicating a mechanistic relationship between environmental antigen exposure and subsequent allergy.

Nature research paper: Environmentally driven immune imprinting protects against allergy

go.nature.com/46lGExb

Excited to participate in the event and share our ongoing work in this space. Join!

This is figure three, which shows different microscopy modalities for in vivo imaging of the immune system.

Immune interactions are complex, dynamic and difficult to capture using static imaging modalities on in vitro or ex vivo tissue cultures. A Review in Nature Reviews Bioengineering discusses techniques for in vivo imaging of the immune system. go.nature.com/4qR4eKI 🔒

📣 PI – G5 positions at Institut Pasteur
@institutpasteur.bsky.social

Join this Vibrant research environment !
Deadline is the Feb. 9th.

Advanced Immunology Pasteur Course - Student testimonial YouTube video by Institut Pasteur EDUCATION

🧫 When training sparks inspiration! Spotlight on the Advanced Immunology Pasteur Course

This course immerses participants in the immune system's complexities through lectures seminars, and cutting-edge lab work.

🎥In this video Amélie Fayolle, 2nd year Master student shares her experience 👇

Pathogen Immunity and Signalling Viruses, bacteria, and other pathogens pose a serious threat to human health, requiring a coordinated response from the innate and adaptive immune systems. Our immune system relies on pathogen recept…

🔥 Mark the date! 🗓️

Millésime 2026 of the @embo.org Workshop on Pathogen Immunity and Signaling has arrived.

Terrific roster of speakers, many spots for talks, spectacular venue in Leiden.

Submit your abstract.

Join us on 8 – 11 June 2026.

meetings.embo.org/event/26-pat...

Excited to share our new paper in @pnas.org , led by @jdllkss.bsky.social in collaboration with @michelenamorado.bsky.social! We show how the immune system’s response to skin microbes can cause nerve overgrowth and chronic itch, via the molecule IL-17A. ow.ly/LfyU50XQ16y

Highlights in our first 2026 issue:
NLRP6 can sense you bacteria
Immunemap data sharing in intravital imaging
…
ADP-ribosylation as protein degradation mark
Damage sensing in PINK1-Parkin–mediated mitophagy
Perspective: innate immunity in tumor immunosurveillance
…
link.springer.com/journal/4431...

Local B cell maturation and mast cell regulation of choroid plexus function in early life. Postnatal development is a critical period for the maturation of the nervous and immune systems. The choroid plexus (CP) within the brain ventricles guides brain development through the production of ...

Excited to share our new preprint: “Local B cell maturation and mast cell regulation of choroid plexus function in early life” www.biorxiv.org/content/10.1... , initiated in the lab by Laetitia Travier and led by the one and only @fakesamir.bsky.social

Reframing IL-27: a central regulator of CD8+ T cell immunity Interleukin-27 (IL-27), a member of the IL-12 cytokine family, was long viewed primarily as a regulator of CD4+ T cell immunity. Subsequent studies revealed that IL-27 also directly modulates CD8+ T c...

Want to learn all there is to know about IL-27? Read the review written by @valentinavenzin.bsky.social et al.
dlvr.it/TPMYD7

Polymerase theta repairs persistent G1-induced DNA breaks in S-phase during class switch recombination Nature Communications - NHEJ is the primary repair pathway during class switch recombination. Here the authors show that in absence of NHEJ, Pol θ repairs persistent G1-induced breaks in...

🚨 Check out our latest article! 🚨
Spoiler: when NHEJ is out, polymerase theta steps in to fix persistent G1-phase breaks during the next S phase — not in mitosis! And for our fellow B cell fans, we explore how Pol θ contributes to immunoglobulin class switching.

@natcomms.nature.com
rdcu.be/eRTSe

Creation of new junior research groups at the Institut Pasteur - Call for applications 2026 - Research The Institut Pasteur is launching an international call to recruit new junior research group leaders leveraging cutting-edge transdisciplinary approaches to exploring infectious diseases, host-microbe...

🔬 Call to create junior research groups at the Institut Pasteur

Focus: Infectious diseases, host-microbe interactions, vaccines
Special interest: AI methodologies

📅 Deadline: Feb 9, 2026
👥 2-12 years post-PhD

Apply now 📝 research.pasteur.fr/en/call/crea...

#JobOpportunity #Research

🧬🛡️How are new immune mechanisms created?

We show how Lamassu antiphage system, originated from a DNA-repair complex and evolved into a compact and modular immune machine, wt Dinshaw Patel lab in @pnas.org.
👏 @matthieu-haudiquet.bsky.social, Arpita Chakravarti & all authors!

doi.org/10.1073/pnas...

Mid-career Group Leader position in AI in genomics at Institut Pasteur, Paris - Research Institut Pasteur and the CNRS are launching a call for a mid-career group leader position in AI in genomics. We are looking for an experienced researcher (typically with > 8 years of research experien...

There a is a joint call between @pasteur.fr and @cnrsbiologie.bsky.social for a mid career group leader position in AI and genomics (or molecular biology). Don't hesistate to spread the word if you know anyone relevant.

research.pasteur.fr/en/call/mid-...

Pour chaque vie, la science agit. Le Pasteurdon, c’est maintenant ! Soutenez la recherche et celles et ceux qui la font avancer. Faites un don sur pasteurdon.fr

Pour chaque vie, la science agit.
Le Pasteurdon, c’est maintenant !
Soutenez la recherche et celles et ceux qui la font avancer ↘️ pasteurdon.fr
#Pasteurdon

📣 Next seminar this Friday the 26th at 12am
@immunopasteur.bsky.social

Cécile Bénézech, from Centre for Cardiovascular Science, University of Edinburgh

Understanding B cell & neutrophil dysfunction
in cardiometabolic diseases 

Invited by Louise Gorline & Pierre Guermonprez

Communiqué de presse : financement de la recherche publique : la communauté scientifique alerte sur un système à bout de souffle. #veilleESR, @info.gouv.fr @agencerecherche.bsky.social @cnrs.fr @franceuniversites.bsky.social @inserm.fr @inrae-france.bsky.social @enseignementsup-recherche.gouv.fr

Nouveau Diplôme Universitaire Thérapeutiques Immunologiques

Porté par @upcite.bsky.social dans le cadre de la Graduate School Innovative Therapies in Cancerology

Avec l'intervention de 6 expert·e·s de l'Institut Pasteur

Formation en ligne en français de octobre 2025 à avril 2026

👉 bit.ly/4ptn0Y3

A human homolog of SIR2 antiphage proteins mediates immunity via the Toll-like receptor pathway Key actors of mammalian immunity originated from bacterial antiphage systems. The full extent of immune system conservation between bacteria and eukaryotes is unknown. Here, we show that the silent in...

#NatMicroPicks

Ancient Proteins, Modern Immune Insights! 🦠

A conserved protein family member activates inflammation via the Toll-like receptor pathway in mammals highlighting new aspects of human immunity.

www.science.org/doi/10.1126/...

👏 Huge congrats to @audeber.bsky.social, group leader and head of our Molecular Diversity of Microbes lab, on being named a 2025 Vallee Scholar! Her pioneering work on ancestral immunity opens new perspectives for biomedical innovation. 🔬🌍

@valleefoundation.bsky.social

#Science #Immunity

📣 Next friday the 12th, @immunopasteur.bsky.social we are hosting Anna Obenauf, @obenaufa.bsky.social for a joint seminar with Institut Curie

Unlocking immunity: decoding & reprogramming the immune-evasive tumor microenvironment

Invited by Pierre Guermonprez & Anna Maria Lennon

📣 Immunology weelky seminar

Friday the 5th , join to listen Prof. Ralf Nanan, from the University of Sydney, Australia

Childhood eczema linked to mother’s stress during pregnancy The causes of early-life eczema have been unclear, but evidence indicates that changes to fetal immune cells and sensory neurons during pregnancy play a key part.

The causes of early-life eczema have been unclear, but evidence indicates that changes to fetal immune cells and sensory neurons during pregnancy play a key part

go.nature.com/45Y9aUQ

📣Next @immunopasteur.bsky.social seminar this Friday

Nelson Gekara from Stockholm University

Role of Intracellular DNA sensors in innate immunity and genome stability

Invited by Gérard Eberl

📣Next @immunopasteur.bsky.social seminar today
Mikäel Pittet (Université de Genève)
Myeloid cells: Microenvironmental coordination in cancers
Invited by Philippe Bousso