🎉 Welcome to BLOODPAC, @Twist Bioscience! 🧬
Twist Bioscience is a biotech company that develops & manufactures synthetic DNA using a silicon-based platform.
To learn more about Twist Bioscience, visit:
👉 www.twistbioscience.com
How Twist DNA is supporting HIV research!
Melissa Smith, & team, including our own @tingfordha.bsky.social develop a long-read pipeline to define HIV reservoirs in this new paper: journals.plos.org/plospathogen...
✨6 ✨ of our favorite groundbreaking publications from 2025, as curated by Twisters! Check them out below…
François Boemer & team demonstrate the importance of integrating biochemical & genomic methods in NBS programs as they report the results of the first 18 months of the ongoing observational study BabyDetect. Read “Population-based, first-tier genomic newborn screening in the maternity ward” here:
Look forward to seeing everyone at #ASHG25! Our poster will showcase how we can bring exome sequencing to the next level -
Board 8011F: Utilization of Twist CNV Backbone Spike-in Panel with exome for replacing cytogenetic arrays
Stop by @twistbioscience.com booth #559 for more info
Couldn’t be prouder of this collaboration on targeted long-read sequencing for pharmacogenomics! #PGx
The cells in our bodies constantly acquire mutations. But what are the patterns of mutations across tissues? How do mutations in normal cells lead to cancer and disease? These are questions we will tackle within the Somatic Mosaicism across Human Tissues (SMaHT) Network, now described in @nature.com
Excited to share our new paper! We benchmarked the Twist Ancient DNA kit for in-solution enrichment. It’s cost-effective, robust, and shows no allelic bias, even when pooling libraries!
@acadresearch.bsky.social @dnatimetravel.bsky.social @twistbioscience.com
doi.org/10.1186/s130...
Comparison of spatial transcriptomics technologies using tumor cryosections. #SpatialTranscriptomics #TechnologiesBenchmarking #Genomics #Bioinformatics #GenomeBiology 🧬 🖥️
genomebiology.biomedcentral.com/articles/10....
Preprint on "Improving spliced alignment by modeling splice sites with deep learning". It describes minisplice for modeling splice signals. Minimap2 and miniprot now optionally use the predicted scores to improve spliced alignment.
arxiv.org/abs/2506.12986
from our own @tingfordha.bsky.social — Development and validation of HIV SMRTcap for the characterization of HIV-1 reservoirs across tissues and subtypes:
www.biorxiv.org/content/10.1...
Systematic identification of disease-causing promoter and untranslated region variants in 8040 undiagnosed individuals with rare disease #RareDisease #Genetics genomemedicine.biomedcentral.com/articles/10....
FYI: New online! Transcriptomics in the era of long-read sequencing
✅ 1283 from University at Buffalo - Targeted genetic profiling of a de novo neuroendocrine patient-derived xenograft (PDX) and organoid model of prostate cancer from patient with African Ancestry www.abstractsonline.com/pp8/#!/20273...
✅ 7173 from Universitätsklinikum Münster: Comprehensive genomic profiling reveals novel insights into the genomic landscape of extraskeletal myxoid chondrosarcomas www.abstractsonline.com/pp8/#!/20273...
✅ 3240 from IMBdx and Yonsei University: Analytical validation of CancerDetect RUO assay: a minimal residual disease detection test that integrates tumor-informed and tumor-agnostic approaches with large-scale mutation monitoring www.abstractsonline.com/pp8/#!/20273...
✅ 1492 from Universitätsklinikum Münster: Clinical validation on the PAOLA-1/ENGOT-ov25 cohort of HRD calculation performed with the #OncoDEEP kit comprehensive genomic panel www.abstractsonline.com/pp8/#!/20273...
✅ 225 from Scale Biosciences: Single Cell DNA methylomes from multiple tissues demonstrate tissue heterogeneity and target enrichment as a driver of read utility www.abstractsonline.com/pp8/#!/20273...
✅ 1263 from MD Anderson Cancer Center: Reconstructing small cell lung cancer evolution using deep whole genome sequencing of circulating tumor DNA www.abstractsonline.com/pp8/#!/20273...
✅ 1108 from AstraZeneca: Tissue and circulating DNA methylation profiling can recapitulate SCLC heterogeneity to enable identification of new biomarkers of clinical relevance www.abstractsonline.com/pp8/#!/20273...
I’m heading to #AACR25 in Chicago! Please look out for me if you'd like to speak about anything from liquid biopsy to CGP to WES to WGS to long-read sequencing!
Here is my must-see list of posters -
Our first curated draft somatic structural variant benchmark for the new GIAB PDAC tumor cell line HG008-T is at ftp-trace.ncbi.nlm.nih.gov/ReferenceSam..., based on extensive short+long read sequencing data described in doi.org/10.1101/2024.... Feedback to improve future versions is very welcome!
#RareDiseaseDay #WES #LongRead @twistbioscience.com
- In collaboration with @sedlazeck.bsky.social et al. at BCM-HGSC we developed a long-read Dark Genes panel that allows researchers to interrogate whatever was not accessible with short-read WGS by “Closing the gap: Solving complex medically relevant genes at scale” www.medrxiv.org/content/10.1...
- In this interactive TechNote Twist Exome has the most uniform coverage compared to 4 competing panels. Combining a low duplicate rate and high on-target rate, it covers 97% of the target bases at least 30x coverage with only 6Gb sequencing www.twistbioscience.com/resources/te...
- Radboud UMC in Nijmegen demonstrated that Twist exome capture allows for lower average sequence coverage in clinical exome sequencing humgenomics.biomedcentral.com/articles/10.... @radboudumc.bsky.social
Today is Rare Disease Day, we’re thankful that researchers and clinicians have been utilizing @twistbioscience.com products for solving these puzzles. Here are some highlights:
nf-core/variantbenchmarking v1.0.0: Nextflow pipeline to evaluate and validate the accuracy of variant calling methods https://github.com/nf-core/variantbenchmarking 🧬🖥️🧪
Lancet2: Improved and accelerated somatic variant calling with joint multi-sample local assembly graph https://www.biorxiv.org/content/10.1101/2025.02.18.638852v1
Unlock targeted single-cell sequencing with Twist Exome Enrichment Kits, powered by #PacBio Kinnex. This robust workflow enriches spliced mRNA from single-nuclei libraries for high-res transcript discovery. Check out our tech note & learn more at our #AGBT Lanai Suite 289! bit.ly/3QqD6l5
