@sinaihealth
Official account for the Sinai Health research ecosystem in Toronto, comprising the Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Hennick Bridgepoint Hospital and Science of Care Institute. https://www.sinaihealth.ca/
LTRI’s Dr. Andras Nagy and Dr. Danny Chan at Hong Kong University have achieved long-term engraftment of stem cells in the body without eliciting immune rejection - in a step toward universal source of cells for therapy.
@isscr.org
Read more ➡️ www.isscr.org/isscr-news/c...
#LTRI #StemCellResearch
Understanding where genes & proteins are expressed in tissue helps researchers uncover how disease develops.
Using the Leica BOND RX, our pathology team automates complex staining, saving time & delivering precise insights at the cellular level.
Learn more ➡️ phenogenomics.ca
#LTRI #Histology
5/5: Learn more about this work in their paper published in Genes & Development ➡️ genesdev.cshlp.org/content/earl...
4/5: The PNC appears briefly during the earliest stages of human development, then disappears — unless it re-emerges in cancer.
Understanding how it turns on and off during embryogenesis could open new strategies to target cancer.
3/5: The PNC forms from non-coding regions of DNA, sometimes called genomic “dark matter.”
In cancer, it boosts production of molecules needed for rapid cell growth and division, helping tumours grow and spread. 🧬
2/5: Led by Dr. Kirti Mittal in the lab of Dr. Miguel Ramalho-Santos @mrsantos.bsky.social, the team discovered that human embryonic stem cells contain a structure called the perinucleolar compartment (PNC).
Until now, the PNC was thought to exist only in cancer cells. 🧫
1/5: Researchers at the Lunenfeld-Tanenbaum Research Institute have discovered a surprising new link between embryonic development and cancer, further strengthening the idea that cancer may grow by reactivating genetic programs normally used only in the earliest stages of life.
Thread below ⬇️
5/5: Learn more about this work in their paper published in Genes & Development ➡️ genesdev.cshlp.org/content/earl...
4/5: The PNC appears briefly during the earliest stages of human development, then disappears — unless it re-emerges in cancer.
Understanding how it turns on and off during embryogenesis could open new strategies to target cancer.
3/5: The PNC forms from non-coding regions of DNA, sometimes called genomic “dark matter.”
In cancer, it boosts production of molecules needed for rapid cell growth and division, helping tumours grow and spread. 🧬
2/5: Led by Dr. Kirti Mittal in the lab of Dr. @mrsantos.bsky.social, the team discovered that human embryonic stem cells contain a structure called the perinucleolar compartment (PNC).
Until now, the PNC was thought to exist only in cancer cells. 🧫
Congratulations to Sinai Health researchers Drs. Kieran Campbell, Daniel Drucker, Rayjean Hung, Sabrina Kolker and Ravi Retnakaran, on receiving a funding boost from the CIHR to investigate the prevention of obesity-related cancers.
Learn more ➡️ www.canada.ca/en/institute...
The Incucyte® LiveCell Analysis System at the NBCC lets researchers measure real-time cell dynamics inside the incubator. It captures continuous images and turns them into data on cell growth, movement, immune cell activity & more.
Learn more ➡️ nbcc.lunenfeld.ca/High-Content...
ICYMI: Learn how Dr. Christina Reppas-Rindlisbacher is working to translate research into practice to improve care for older adults, including examining how language influences health outcomes in geriatric care.
Read the full story ➡️ www.sinaihealth.ca/foundation/o...
A male scientist examining a petri dish in a research laboratory. He is wearing a white coat and purple gloves
Congratulations to Dr. Daniel Schramek #LTRI and collaborators on receiving a funding boost from philanthropy to identify genetic changes driving brain cancer.
Find out more about his projects targeting glioblastoma and low-grade glioma👇
www.sinaihealth.ca/news/scienti...
The Network Biology Collaborative Centre offers access to 270K+ small-molecule compounds, including 13 bioactive libraries and 5 large diversity libraries for automated in vitro cell and organoid screens.
Learn how we can support your research ➡️ nbcc.lunenfeld.ca/High-Through...
ICYMI: A landmark guide for stem cell therapy authored by global leaders in stem cell and regenerative medicine research, including Sinai Health's Dr. Andras Nagy, Senior Investigator at #LTRI
Read more ⬇️
📣 Research from @uoftmedicine.bsky.social and Sinai Health shows that safe testing during pregnancy can keep first-line antibiotics on the table and improve outcomes.
Read more ⬇️
Curious about the structural architecture of human cells?
The Nikon A1R Confocal System at the Network Biology Collaborative Centre captures dynamic microtubule changes in real time.
📷: Dr. Amit Sharma
Learn more: nbcc.lunenfeld.ca/Advanced_Ima...
#NBCC #LTRI #Imaging
🎉 This International Day of Women & Girls in Science, we celebrate the next generation of leaders pushing boundaries of discovery science at the Lunenfeld-Tanenbaum Research Institute, Sinai Health.
www.sinaihealth.ca/news/meet-th...
#WomenInScience #IDWGS2026
We’re proud to share that Sinai Health has been recognized among Canada’s Top 40 Research Hospitals 🧠🔬
A recent article shared by @onthospitalassn.bsky.social highlights the role hospital-based research plays in advancing innovation and patient care.
Read more: www.oha.com/news/improvi...
The Croitoru Lab's new blood test for Crohn's disease was supported by Sinai Health's Biospecimen Repsoitory, an accredited biobank storing 600, 000+ samples and enabling research across the organization and beyond.
➡️ www.sinaihealth.ca/news/a-simpl...
➡️ research.lunenfeld.ca/bsr/
In the latest @theglobeandmail.com feature, Sinai Health’s Dr. @danieljdrucker.bsky.social is recognized for the discovery that helped lead to Ozempic - and the ongoing breakthroughs unfolding at Sinai Health today.
Read the full story here:
🎉 Congratulations to Sinai Health researchers on receiving >$6.7M in research funding from CIHR to advance research in biomedicine, disease and life-changing care.
Learn more: bit.ly/4qYsxq7
The Network Biology Collaborative Centre is equipped with the Thermo Scientific Orbitrap Astral mass spectrometer which offers high-throughput, deep proteomic coverage in less time for high-quality results. nbcc.lunenfeld.ca/proteomics
🚨Deadline extended! To all research trainees, you still have time to submit your abstracts. Don't miss this important deadline.
🔬 Indica Labs & the TCP Pathology Core are hosting a HALO® Research Platform workshop on January 27th, 2026!
Learn powerful, intuitive image analysis for digital pathology—IHC, multiplex, spatial analysis & more.
Register here ➡️ forms.office.com/Pages/Respon...
Sinai Health is proud to spotlight the Ontario Birth Study that advances research in pregnancy, infant health & early childhood. Thanks to generous participants, researchers have access to valuable data & biospecimens to drive breakthrough.
Learn more: ontariobirthstudy.com
📣 Dr. Christian Pagnoux, clinician scientist at the Lunenfeld-Tanenbaum Research Institute, part of Sinai Health, and colleagues have published a paper in @jrheumatol.bsky.social, assessing barriers to care reported by Canadian vasculitis patients and healthcare providers.
Read more ⬇️
Sinai Health’s in-house experts are assisting researchers advance their projects with the latest approaches in flow cytometry & cell sorting.
Learn more:
nbcc.lunenfeld.ca/Flow_Cytometry
