Endocrine Society Journals

Prolonged Somatostatin Receptor 2 Antagonism Enhances Glucagon Response to Hypoglycemia in Male Diabetic Rats. Read more in #Endocrinology: bit.ly/4bdMRya #Glucagon #hypoglycemia #Type2Diabetes @endocrinesociety.bsky.social

Activity of Cardiomyocyte Type 3 Deiodinase After Myocardial Infarction Influences Cardiac Recovery in Females Abstract. Thyroid hormone (TH) is essential for cardiovascular function, and women are disproportionately affected by TH disorders and experience worse out

Activity of Cardiomyocyte Type 3 Deiodinase After Myocardial Infarction Influences Cardiac Recovery in Females. Read more in #Endocrinology: bit.ly/4s4oeK6 #Type3Deidinase #MyocardialInfarction #ThyroidHormones @endocrinesociety.bsky.social

Impact of Minimal Dose Strategy Before Antithyroid Drug Discontinuation on Relapse Risk in Graves’ Disease AbstractBackground. Although antithyroid drugs (ATDs) are widely used as the first-line therapy for Graves’ disease, relapse after treatment discontinuatio

Impact of Minimal Dose Strategy Before Antithyroid Drug Discontinuation on Relapse Risk in Graves’ Disease. Read more in #JCEM: bit.ly/3MSCTcb #GravesDisease #Methimazole #AntiThyroidDrugs @endocrinesociety.bsky.social

Acyl-CoA Synthetase 5 Knockout and Inhibitors Protect Against Diet-Induced Obesity in Mice by Activating the Ileal Brake Abstract. Genes regulating body fat are shared by mice and humans, and mouse knockout phenotypes for known drug targets correlate well with drug efficacy,

Acyl-CoA Synthetase 5 Knockout and Inhibitors Protect Against Diet-Induced Obesity in Mice by Activating the Ileal Brake. Read more in #JES: bit.ly/46L7uPA #GeneKnockout #inhibitor #obesity @endocrinesociety.bsky.social

Mild Autonomous Cortisol Secretion in Congenital Adrenal Hyperplasia Managed With Mini Back Scope Adrenalectomy Abstract. A 55-year-old woman, diagnosed with 21-hydroxylase deficiency congenital adrenal hyperplasia (CAH) at age 7 years in the mid-Atlantic United Stat

Mild Autonomous Cortisol Secretion in Congenital Adrenal Hyperplasia Managed With Mini Back Scope Adrenalectomy. Read more in #JCEMCaseReports: bit.ly/4rr1iEV #Sepsis #SepticShock #Inflammation @endocrinesociety.bsky.social

Acute Autonomic Sensory Neuropathy Causing Severe Hyponatremia: A Rare Cause of Syndrome of Inappropriate Antidiuresis Abstract. A 25-year-old woman had experienced dizziness and numbness following a recent fever accompanied by upper respiratory symptoms. She was subsequent

Acute Autonomic Sensory Neuropathy Causing Severe Hyponatremia: A Rare Cause of Syndrome of Inappropriate Antidiuresis. Read more in #JCEMCaseReports: bit.ly/4aEueSn #Hyponatremia #AcuteAutonomicSensoryNeuropathy @endocrinesociety.bsky.social

Carbohydrate Ingestion on Exercise Metabolism and Physical Performance Abstract. Carbohydrate (CHO) ingestion during exercise has long been associated with improved performance. Early Scandinavian research proposed that CHO in

Carbohydrate Ingestion on Exercise Metabolism and Physical Performance. Read more in #EndocrineReviews: bit.ly/46QlgjZ #Carbohydrates #Metabolism #Glycogen @endocrinesociety.bsky.social

A Novel Evaluation of 24-hour Energy Metabolism in Cushing's Syndrome: The Metabolic Cost of Hypercortisolism AbstractContext. Hypercortisolism leads to metabolic alterations (glucose dysregulation, increased protein catabolism, and increased lipolysis and lipogene

A Novel Evaluation of 24-hour Energy Metabolism in Cushing's Syndrome: The Metabolic Cost of Hypercortisolism. Read more in #JES: bit.ly/4bXu7Uu #ProteinOxidation #CushingsSyndrome #LeanSoftTissue @endocrinesociety.bsky.social

Sex Hormones Mediate Intensive Lifestyle Intervention–Induced Bone Mineral Density Changes: Look AHEAD Sex Hormone Study AbstractContext. The Look AHEAD (Action in Health for Diabetes) randomized controlled trial, which compared an Intensive Lifestyle Intervention (ILI) to Di

Sex Hormones Mediate Intensive Lifestyle Intervention–Induced Bone Mineral Density Changes: Look AHEAD Sex Hormone Study Get access Arrow. Read more in #JCEM: bit.ly/4aL2Baz #Mediation #SexHormones #diabetes @endocrinesociety.bsky.social

Severe Refractory Calcitriol-Mediated Hypercalcemia in Diffuse Large B-Cell Lymphoma Treated With Hemodialysis Abstract. Hypercalcemia of malignancy is a recognized complication of diffuse large B-cell lymphoma (DLBCL) and is associated with decreased survival time

Severe Refractory Calcitriol-Mediated Hypercalcemia in Diffuse Large B-Cell Lymphoma Treated With Hemodialysis. Read more in #JCEM Case Reports: bit.ly/4kJwigJ #nonHodgkinLymphoma #calcitriol #HypercalcemiaofMalignancy @endocrinesociety.bsky.social

Improving MASLD Risk Stratification in Young Adults with Cardiometabolic Risk Factors and Insulin Resistance Assessment AbstractContext. The fibrosis-4 index (FIB-4) index is recommended to identify adults with metabolic dysfunction-associated steatotic liver disease (MASLD)

Improving MASLD Risk Stratification in Young Adults with Cardiometabolic Risk Factors and Insulin Resistance Assessment. Read more in #JES: bit.ly/4aYXPY7 #obesity #CardiometabolicRiskFactors #DiabetesMellitusType2 @endocrinesociety.bsky.social

The Role of Cortisol Secretion in Pheochromocytomas and Paragangliomas: Clinical and Perioperative Implications AbstractBackground. Pheochromocytomas and paragangliomas (PPGLs) are tumors marked by excessive catecholamine secretion. Patients with pheochromocytomas ma

The Role of Cortisol Secretion in Pheochromocytomas and Paragangliomas: Clinical and Perioperative Implications. Read more in #JCEM: bit.ly/4kTQw7x #Paraganglioma #CardiovascularDisease #MetanephrineConcentrations @endocrinesociety.bsky.social

GH Alters Lymphatic Vessels in Female Mice and STAT5 Phosphorylation in Human Lymphatic Endothelial Cells. Read more in #Endocrinology: bit.ly/4kNa4ui #GrowthHormoneResponse #LymphaticSystem #LymphaticPumping @endocrinesociety.bsky.social

Insulinoma Unmasked By Tirzepatide: A Rare Case of Postprandial Hypoglycemia In a Nondiabetic Patient Abstract. A 63-year-old woman with obesity presented with severe postprandial hypoglycemia that worsened after starting tirzepatide for weight loss. Furthe

Insulinoma Unmasked By Tirzepatide: A Rare Case of Postprandial Hypoglycemia In a Nondiabetic Patient. Read more in #JCEMCaseReports: bit.ly/4ta09mr #insulinoma #Tirzepatide #NeuroendocrineTumor @endocrinesociety.bsky.social

Mechanisms of Testosterone's Anabolic Effects on Muscle and Function: Controversies and New Insights Abstract. Testosterone treatment increases muscle mass, maximal voluntary muscle strength, aerobic capacity, and some measures of physical function. Activa

Mechanisms of Testosterone's Anabolic Effects on Muscle and Function: Controversies and New Insights. Read more in #EndocrineReviews: bit.ly/4pXuYrp #testosterone #Androgens #MyogenicDifferentiation @endocrinesociety.bsky.social

Time-dependent Increase in Cortisol after 1-mg Overnight Dexamethasone Suppression Test in Adrenal Incidentalomas AbstractBackground. Guidelines recommend the 1-mg overnight dexamethasone suppression test (ODST) for diagnosing mild autonomous cortisol secretion (MACS)

Time-dependent Increase in Cortisol after 1-mg Overnight Dexamethasone Suppression Test in Adrenal Incidentalomas. Read more in #JES: bit.ly/49OCZsE #AdrenalIncidentaloma #cortisol #OvernightDexamethasonSuppressionTest @endocrinesociety.bsky.social

Parathyroidectomy Restores Muscle Strength and Transcriptome in Individuals With Primary Hyperparathyroidism AbstractContext. Primary hyperparathyroidism leads to hypercalcemia and muscle dysfunction. Muscle weakness is associated with increased morbidity and mort

Parathyroidectomy Restores Muscle Strength and Transcriptome in Individuals With Primary Hyperparathyroidism. Read more in #JCEM: bit.ly/3LBzNsD #Parathyroidectomy #MuscleStrength #PrimaryHyperparathyroidism @endocrinesociety.bsky.social

Maternal Exposure to Ozone During Implantation Promotes a Feminized Transcriptomic Profile in the Male Adolescent Liver Abstract. Maternal exposure to ozone during implantation results in reduced fetal weight gain in rats. Offspring from ozone-exposed dams demonstrate sexual

Maternal Exposure to Ozone During Implantation Promotes a Feminized Transcriptomic Profile in the Male Adolescent Liver. Read more in #Endocrinology: bit.ly/45z9biz #HepaticFeminization #DevelopmentalReprogramming #Ozone @endocrinesociety.bsky.social

Heteromerization of G Protein-coupled Estrogen Receptor With the LH Receptor Biases G Protein Signaling Abstract. LH/choriogonadotropin (hCG) receptor (LHCGR) and the G protein-coupled estrogen receptor (GPER) are coexpressed in the ovary and support reproduc

Heteromerization of G Protein-coupled Estrogen Receptor With the LH Receptor Biases G Protein Signaling. Read more in #Endocrinology: bit.ly/49zJVes #GPER #LHCGR #LH #hCG #GqProtein @endocrinesociety.bsky.social

Genetic Risk and Transition Through Preclinical Stages of Type 1 Diabetes AbstractContext. The influence of genetic factors on the transition through preclinical stages of type 1 diabetes (T1D) has not been studied.Objective. Our

Genetic Risk and Transition Through Preclinical Stages of Type 1 Diabetes. Read more in #JCEM: bit.ly/4baJpVA #EarlyType1DiabetesMarkers #GeneticRiskFactors #Type1Diabetes @endocrinesociety.bsky.social

Effect of Continuous Glucose Monitoring Following Hospital Discharge of Patients With Type 2 Diabetes AbstractContext. The post-hospitalization period is a vulnerable time for patients with type 2 diabetes (T2D).Objective. To assess usefulness of continuous

Effect of Continuous Glucose Monitoring Following Hospital Discharge of Patients With Type 2 Diabetes. Read more in #JES: bit.ly/3LT4hpY #ContinuousGlucoseMonitor #Type2Diabetes @endocrinesociety.bsky.social

Mechanism and Context: Making Sense of Adverse Events With GLP-1-based Therapy Glucagon-like peptide 1 (GLP-1)-based therapies have reshaped the clinical approach to type 2 diabetes and obesity [1]. Long-acting GLP-1 receptor agonists

Mechanism and Context: Making Sense of Adverse Events With GLP-1-based Therapy. Read more in #JCEMCaseReports: bit.ly/4sPm2qX #AdverseEvents #diabetes #GLP-1BasedTherapy #obesity @endocrinesociety.bsky.social

The Endocrinological Basis for Polycystic Ovary Syndrome: An Evolutionary Perspective Abstract. As a common endocrinopathy of reproductive-aged women, polycystic ovary syndrome (PCOS) is characterized by ovarian hyperandrogenism, insulin res

The Endocrinological Basis for Polycystic Ovary Syndrome: An Evolutionary Perspective. Read more in #Endocrinology: bit.ly/45mLtpP #PolycysticOvarySyndrome #Hyperandrogenism #Evolution @endocrinesociety.bsky.social

An Unusual Etiology of Recurrent Parathyroid Hormone–Independent Hypercalcemia Abstract. The diagnosis of parathyroid hormone (PTH)-independent hypercalcemia can be challenging due to its heterogeneous etiology. We report a case of a

An Unusual Etiology of Recurrent Parathyroid Hormone–Independent Hypercalcemia. Read more in #JCEMCaseReports: bit.ly/4sWbcQ6 #Hypercalcemia #Sarcoidosis #ParathyroidHormone @endocrinesociety.bsky.social

Hepatic Glucocorticoid Receptor Action and Glucose Homeostasis Abstract. One of the major metabolic functions of glucocorticoids (GC) is to maintain circulating glucose levels during stress, as glucose is the preferred

Hepatic Glucocorticoid Receptor Action and Glucose Homeostasis. Read more in #EndocrineReviews: bit.ly/3YS3bxH #Glucocorticoids #Gluconeogenesis #InsulinResistance @endocrinesociety.bsky.social

Clomiphene Citrate in Men With Hypogonadism—Do we Need to Monitor IGF-1 in All Patients? Selective estrogen receptor modulators (SERMs) emerged as a plausible option for acromegaly treatment due to their estrogen-like effect of reducing insulin

Clomiphene Citrate in Men With Hypogonadism—Do we Need to Monitor IGF-1 in All Patients?. Read more in #JES: bit.ly/4pU09UK #SERMs #IGF-1 #ClomipheneCitrate @endocrinesociety.bsky.social

Clinical Significance of Successful Ablation in Follicular Thyroid Carcinoma AbstractContext. Outcomes of postoperative ablation focused on follicular thyroid carcinoma (FTC) have not been fully investigated.Objective. The purpose o

Clinical Significance of Successful Ablation in Follicular Thyroid Carcinoma. Read more in #JCEM: bit.ly/49MN4Xk #FollicularThyroidCarcinoma #PostoperativeAblation @endocrinesociety.bsky.social

Cabergoline-Induced Gambling Causing Increased Adrenal Crisis Episodes Abstract. Dopamine agonists have been used in the treatment of acromegaly, but they are modestly effective and are rarely associated with impulse control d

Cabergoline-Induced Gambling Causing Increased Adrenal Crisis Episodes. Read more in #JCEMCaseReports: bit.ly/4pNVtj6 #acromegaly #DopamineAgonists #CabergolineImpulseControlDisorders @endocrinesociety.bsky.social

Sex and Seasonal Variations in Melatonin Suppression and Alerting Response to Light Abstract. Light influences human physiology and behavior by regulating circadian rhythms, melatonin secretion, and alertness. Previous research has reporte

Sex and Seasonal Variations in Melatonin Suppression and Alerting Response to Light. Read more in #JES: bit.ly/45YENOD #SexDifferences #DimLightMelatoninOnset #LightSensitivity @endocrinesociety.bsky.social

Beneficial Effects of Carbohydrate Restriction in Type 2 Diabetes Can Be Traced to Changes in Hepatic Metabolism AbstractContext. Carbohydrate restriction benefits metabolic health in patients with type 2 diabetes (T2D), possibly through changes in hepatic metabolism.

Beneficial Effects of Carbohydrate Restriction in Type 2 Diabetes Can Be Traced to Changes in Hepatic Metabolism. Read more in #JCEM: bit.ly/3ZtMust #KetogenicDiet #Type2Diabetes #LiverFat #DeNovoLipogenesis @endocrinesociety.bsky.social