One for @laurencepearl.bsky.social
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10.03.2026 12:17
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One for @laurencepearl.bsky.social
Wordle 1,725 2/6
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Because it also shows “likely fraud” when they, the telephone companies, call you. Madness.
Who is going to want to review under these conditions?
The policy changes. The reductions are real despite all of the gas-lighting. Many scientists think it will be transient or not affect them or that others will care. But there are systematic reductions across the board and it won’t get the attention needed until too late.
OTOH, this will likely be more effective in “voluntary” deportations that ICE could dream about in a decade.
It does align with the sex difference in income for the same job though.
Pretty soon posting to BlueSky will be sufficient cause for deportation.
This is like conducting a bank robbery in broad daylight after advertising it in the NYT under the assumption that since it’s not your bank being rifled, the public won’t be bothered with the details. Except, all the other banks are being systematically targeted over time.
Makes ethical sense for familial disease testing (and even that type of embryo selection will be banned in some Southern States). But thinking you can select only positive attributes without understanding collateral negative attributes that only identify 25 yrs later is 🦇💩 crazy arrogance.
Ditto my Auntie Bella. Taught me so much without me actually realising at the time. Dedicated my PhD thesis to her. She died just before I completed it.
You put your Vinay in, take your Vinay out, you put your Vinay in and you shake the FDA about.
You do the HokeyVinay and you turn around and that’s what it’s all about.
“Let’s concentrate all of these highly explosive tankers in a straight line so we can put them into a tunnel and … hey, where did you go?”
Hoping as many American professors, researchers, trainees & technicians as possible attend the #StandUpForScience rallies across the US tomorrow. It’s an important message to send to Washington, but the rest of the world is also watching & supporting you in taking a stand on attacks on science. 🫡
This is important because while the two enzymes are very similar, there are also some differences in functions as determined by genetic analysis, etc.
In the Wnt pathway, both GSK3 isoforms are found at similar levels in the destruction complex. There are some good alpha selective antibodies (e.g. www.cellsignal.com/products/prima… ) and other reagents.
The only data I saw that is beta-specific is the IF data in Fig 4B. There is an unfortunate bias in the literature twowards GSK-3beta and while there are now some pretty good isoform specific inhibitors (Broad Inst) all of the commerically available ones are non-isoform selective.
Really interesting study! Could you take a look at your data supporting the idea that it is GSK-3beta rather than both GSK-3alpha and beta as both isoforms equally phosphorylate beta-catenin and LRP5/6 and CIHR99021 inhibits both: www.tocris.com/products/chir-….
So you’ve been a walking, talking potential hazard for over 36 years!
Graphic featuring project details. Picture in centre is of Dr. Fradet wearing blue-rimmed glasses, a patterned button-down shirt, and a lab coat with his name and the CHU de Québec Université Laval logo embroidered.
Prostate cancer is the most diagnosed non-skin cancer worldwide and the third leading cause of cancer death in Canada. Yet doctors still lack reliable tools to predict who will develop the disease or identify those at risk of more aggressive forms. With $1 million in TFRI funding, matched by $1 million from the Canadian Cancer Society, a research team led by Dr. Vincent Fradet at the Université Laval will study the gut microbiome of 450 at-risk men to identify predictive markers and explore new, non-invasive prevention strategies.
“Preventing deadly prostate cancers through low-risk, cost-effective interventions, while sparing patients from unnecessary diagnostic procedures, overtreatment and the significant side-effects of aggressive therapies, remains a critical unmet need that we will be tackling in this project,” says Dr. Fradet.
Smarter prostate cancer prevention may begin in the gut.
With $1M in TFRI funding, matched by CCS, a research team led by Dr. Vincent Fradet will study the gut microbiome of 450 at-risk men to predict aggressive disease and reduce overdiagnosis.
Learn more: tinyurl.com/yenve9kp
Jeez… We’re competing with Ottawa for most dysfunctional light rail. The closure at Bay/College for rail repair reroutes the streetcars down McCaul. Sloooow 90 degree turns. At pedestrian crossings. By the University of Toronto. Genius.
And speed camera fines - if only.
Those don’t need controlling. The sheer volume of vehicles automatically limits everything to 10 km/hr or less.
Of course European countries have far better quality of chocolate than the adulterated stuff now being purveyed in the UK. The Cadbury name is being defiled.
Not so much creepy but definitely arrogant. As if most proteins are not in most of our cells.
Ubiquitin is not your friend. Depending on how it gloms onto you, you can get whisked somewhere else, your personality changes forever or you are sent to the garbage dump. It’s the protein version of ICE.
😥
Enshittification is everywhere.
You’d never know that half of these teams (those of Drs. Tai and Ogilvie) are actually being funded by the Terry Fox Research Institute, not CIHR. 🤔
And hilarious that Cadbury is, of course, still required to adhere to (or fail to adhere to) EU standards.
Owned by Mondelez International, based in the US, $5 billion in revenues. What a freaking mission statement. www.mondelezinternational.com