Anna Constance Vind

⚡️Now online⚡️: Our review on how ZAKa and #ribosomes regulate cell death when things go bad ☠️ 🧪 @cellpress.bsky.social @annaconstancevind.bsky.social 👏 ⬇️

Death by ribosome Next to their essential role as protein production factories, ribosomes serve as molecular sensors of cell stress. Stalled and collided ribosomes trigger specific stress signaling, including the ribotoxic stress response (RSR). The RSR is initiated by the mitogen-activated protein (MAP)-3 kinase ZAKα in response to a plethora of translational aberrations, leading to activation of the stress-activated MAP kinases p38 and jun N-terminal kinase (JNK). Recent insights have highlighted an important role for the RSR pathway in triggering programmed cell death processes, including apoptosis and pyroptosis, in a broad range of physiologically relevant conditions. In this review, we summarize recent work on known links between programmed and accidental ribosome toxicity, RSR signaling, and cell death.

✨ Our latest review is now online! ✨
Read about #ZAKa and #ribosomes roles in cell death triggered by:
1️⃣ Environmental and endogenous stressors
2️⃣ Plant and microbial toxins
3️⃣ Celluar pathways leading to self-inflicted ribotoxicity

@bekkerjensenlab.bsky.social 🙏

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www.cell.com/trends/cell-...

✨Back from an inspiring institute retreat! Thanks to all participants and organizers for putting together this exciting program and to Minik Rosing for a wonderful talk about life on our planet 🌍 🌿 @josefcomh.bsky.social @zhenzhenwu.bsky.social @annaconstancevind.bsky.social @melacular.bsky.social

Another cool story from @bekkerjensenlab.bsky.social and @annaconstancevind.bsky.social that sheds light on the hidden mechanisms of sunburn.

Turns out UV light doesn’t just damage DNA. It also activates the ribotoxic stress response in skin cells, driving inflammation, cell death and repair!👇

The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo The acute skin reaction to sunburn, encompassing keratinocyte cell death, inflammation, and epidermal thickening, has traditionally been ascribed to DNA damage responses. Using a mouse model deficient...

Time for our first post here 🥳 Our latest paper is online 🙌
We show that UV activates the ribotoxic stress response, which causes inflammation, cell death and thickening in skin. Read about a role for the RSR separate from DNA damage signaling in response to sunburn: ✨☀️ www.cell.com/molecular-ce...