David Konrad

#photoswitches: How should we determine errors on PSS distributions, and the absorption spectrum of the metastable isomer? We have been discussing this for years and have finally written a manuscript, including a python code to fit your data without human bias. chemrxiv.org/doi/full/10....

A Highly Reactive Cysteine-Targeted Acrylophenone Chemical Probe That Enables Peptide/Protein Bioconjugation and Chemoproteomics Analysis To date, a variety of covalent cysteine-reactive chemical probes have been reported. The most common ones include maleimide for bioconjugation and iodoacetamide alkyne (IAA) for chemoproteomics analys...

Excited to see this study by the group of @dbkonrad.bsky.social out in JACS Au.

Ortho-dichloroacrylophenone is a cysteine-directed electrophile for peptide and protein labeling as well as chemoproteomic profiling. Glad that our group could make a small contribution.

pubs.acs.org/doi/10.1021/...

A perspective on cysteine-reactive activity-based probes Activity-based protein profiling (ABPP) is a powerful method to investigate protein function, identify protein targets and determine the mechanisms-of-action of chemical probes as well as small…

🔓Don't miss this #OpenAccess review from @dbkonrad.bsky.social & co. at @univie.ac.at & @lmumuenchen.bsky.social, part of our New Talent collection providing their perspective on cysteine-reactive activity-based probes #orgchem #chembio

Check it out in full here🔽

I nominate #ProteoProbes 😁

Profiling the proteome-wide selectivity of diverse electrophiles - Nature Chemistry Covalent inhibitors are powerful entities in drug discovery. Now the amino acid selectivity and reactivity of a diverse electrophile library have been assessed proteome-wide using an unbiased workflow...

How can we study target engagement and selectivity of covalent inhibitors? Which electrophilic probes are best suited to study a certain amino acid?

Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7)

www.nature.com/articles/s41...

Scheme of the chemo-enzymatic synthesis of modified nucleoside-5´-triphosphates as mRNA building blocks.

Join us as the first PhD student in my group! Based in the beautiful city of Münster, Germany, you will develop the chemo-enzymatic synthesis of modified nucleotides, which are used as building blocks of mRNA.
Here is the link:
stellen.uni-muenster.de/jobposting/6...

#chemsky #chembio

Early Career Research (ECR) Group Leader position (m/f/d) with the thematic focus on “Catalysis” within the Cluster of Excellence RESOLV

Please check this announcement for an early-career group leader, hosted jointly by our cluster of excellence RESOLV and the MPI Kofo. The thematic focus should be on catalysis: jobs.ruhr-uni-bochum.de/jobposting/4...

Multiple oestradiol functions inhibit ferroptosis and acute kidney injury - Nature 17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules.

Happy to start at Bluesky with a post on our recent manuscript at @nature.com:

www.nature.com/articles/s41...

Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.

Love the concept!!

Same 😊

Big thanks to our co-authors from academia: @fragrisoni.bsky.social, @dirktrauner.bsky.social, Marcel Bermudez and from industry: Marcel Mülbaier and Clemens Dialer (Grünenthal GmbH).

Here, we discuss the potential for the development of analgesics, structure-activity relationships on NaV channels, biosynthetic hypotheses and chemical syntheses.

It is a great pleasure to share that our extensive review on "The Chemistry and Biology of the Tetrodotoxin Natural Product Family" has been accepted for publication at Angewandte Chemie: doi.org/10.1002/anie....

But that is not all! To showcase the potential of dfdc azobenzenes for the development of chemical tools, we synthesized dfdc-OptoBI-1 and demonstrated its biological activity as a red light-operated activator of TRPC6 channels in HEK293 cells.

The data was used to establish a computational approach that allows to compute realistic UV-vis spectra by combining TD-DFT excited-state calculations with MD simulations. As such, our combined experimental and computational study enables the in silico design of new highly red-shifted photoswitches.

In total, we have added 15 new visible light-operated photoswitches to the toolbox for the development of optical devices with relaxation rates across multiple orders of magnitudes and identified several examples with stronger bathochromic shifts than the dfdc azobenzene lead structure.

We have developed synthetic protocols for a variety of derivatives of the dfdc (di-ortho-fluoro-di-ortho-chloro) azobenzene scaffold and performed an in-depth study into their photophysical properties using NMR, UV-vis and X-ray analysis.

I am incredibly excited that our manuscript: "A Platform for the Development of Highly Red-Shifted Azobenzene-based Optical Tools" has been accepted for publication at Angewandte Chemie: doi.org/10.1002/anie... 🤩

We are looking for a PhD candidate in medicinal / organic chemistry with a passion for drug discovery to join our young and enthusiastic team @univie.ac.at. For details, visit: jobs.univie.ac.at/job/Universi.... Reposts are very much appreciated!

We are very excited that we will be hosting the 15th International Activity Based Protein Profiling (ABPP) Meeting in Leiden in 2027. If you do not want to miss anything, make sure to follow this page to see all the information in the future.

📢 Only one more week to apply!

We are looking for a PhD candidate in molecular biology / biochemistry / chemical biology with a passion for drug discovery to join our young and enthusiastic team @univie.ac.at. For details, visit: vds-phanuspo.univie.ac.at/application/.... Reposts are very much appreciated!

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We have a new homepage @tum.de including The Hall of Fame of Graduates - check it out!
👇
www.mls.ls.tum.de/tnm

So cool! 🤩

DNA Mimic Foldamer Recognition of a Chromosomal Protein Biomolecular mimics are intended to outperform their natural counterparts. However, B-DNA surface mimicry to target DNA-binding proteins has long remained underdeveloped. We have introduced helical a...

Please check out our Angew. communication on DNA mimic foldamers that can outcompete DNA itself in the binding of proteins! 🧬

onlinelibrary.wiley.com/doi/full/10....

DOGE By The Numbers
theonion.com/doge-by...

A surprise finding with interesting chemistry: protein bound zinc ions can activate Proton Pump Inhibitors (PPIs)

Thanks to a great collaboration with @aubrykmiller.bsky.social and many colleagues!

www.nature.com/articles/s41...

Thanks Ivana!

Thanks Johannes!

Managing to score a professorship without a Cell, Science or Nature paper.