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Paul Thompson

@ptenigma

Neuroscientist, professor AI guided tour - https://www.youtube.com/watch?v=fOORfzGjCTA ENIGMA guided tour - https://www.youtube.com/watch?v=YNjP5nZsJyQ Diffusion MRI of Brain Diseases - https://www.youtube.com/watch?v=i2jHFm0wcN0

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16.11.2024
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Latest posts by Paul Thompson @ptenigma

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Congratulations to our faculty member Chris Ching on receiving the @usc.edu Bosco S. Tjan Mentorship Award. A well-deserved recognition of his dedication to mentoring and supporting the next generation of scientists! We're thrilled to celebrate this honor πŸŽ‰ 🧠

09.03.2026 16:06 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Here is a great interview on her life in science samizdathealth.org/wp-content/u...

09.03.2026 17:15 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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The Boy Who Couldn't Stop Washing: The Experience and Treatment of Obsessive-Compulsive Disorder The Boy Who Couldn't Stop Washing: The Experience and Treatment of Obsessive-Compulsive Disorder [Rapoport, Judith L.] on Amazon.com. *FREE* shipping on qualifying offers. The Boy Who Couldn't Stop Washing: The Experience and Treatment of Obsessive-Compulsive Disorder

[3] amazon.com/Boy-Couldnt-...
[4] Obituary echovita.com/us/obituarie...
She trained and inspired countless generations of neuroscientists and psychiatrists.

09.03.2026 17:15 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
Judith Rapoport - Normal and Abnormal Brain Development in Children and Adolescents
Judith Rapoport - Normal and Abnormal Brain Development in Children and Adolescents YouTube video by Gustavus Adolphus College

We co-authored many papers together, and time-lapse movies of development, which she explains here "You can make a movie of this if you are willing to wait 12 years" [1,2].
[1] youtube.com/watch?v=4ET8...
[2] youtube.com/watch?v=4ET8...

09.03.2026 17:15 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Very sad to hear of the passing of visionary neuroscientist Dr Judith Rapoport of NIMH, she pioneered neuroimaging in children and was a world expert on childhood and adolescent psychiatric conditions, including schizophrenia + OCD [3]. See video links below πŸ‘‡

09.03.2026 17:15 πŸ‘ 5 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
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πŸ”₯WORKING THIS WEEKEND revising a paper [1] on how much data is needed to train a vision-language model (VLM) to classify brain diseases in radiologic images, and the enigmatic RIEMANN ZETA FUNCTION [0] magically appears (!!)
[0] en.wikipedia.org/wiki/Riemann...
[1] arxiv.org/html/2512.23...

09.03.2026 05:48 πŸ‘ 4 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Thanks Conor !

07.03.2026 17:34 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Art show including paintings on MΓ΅bius strips and knots

02.03.2026 03:34 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

I just saw that on Blue Ridge while looking for something else - HUGE CONGRATS!! That is really awesome :)

24.02.2026 06:24 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Tourette's Experts Agree There's No Easy Answer to John Davidson's BAFTAs Outburst: 'Tics Are Involuntary' Tourette's researchers and experts address the issues surrounding John Davidson's outburst at the BAFTAs towards the "Sinners" cast.

A reporter for The Wrap (a publication focused on entertainment, media, + Hollywood) asked me for a comment on this complex situation
thewrap.com/creative-con...
Thanks to Casey Loving for a thoughtful, nuanced article

24.02.2026 03:27 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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+if the reachable transformations of the network lie in the Lie group generated by its layers, you could use this commutator (+the high order brackets if you like!) to test compressibility. I have not thought about multiple heads, which may increase the rank (noncompressibility) of the Lie algebra

19.02.2026 06:40 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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*If layer i moves features into a region where layer j behaves differently, the Lie bracket (=HOW much applying layer i changes the action of layer j, minus the reverse) is large. but, nearly-commuting layers are compressible, so perhaps you could use fewer layers (or 1!) if the brackets are small.

19.02.2026 06:40 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Animation of a Lie bracket*
*used in compressing neural networks such as transformers or flow maps

19.02.2026 05:43 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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The exponential of a velocity field is the diffeomorphism obtained by following that velocity field for unit time, and the logarithm of a diffeomorphism, when it exists (and this is cool) is the stationary velocity field whose flow produces that map, same idea as matrix exp and log.

16.02.2026 18:30 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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*note we use the words exp and log for maps as it comes from the fact that diffeomorphisms form a kind of infinite-dimensional Lie group, and velocity fields are its Lie algebra.. the log is the velocity at time 0 that generates the full path at time 1.

16.02.2026 18:30 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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πŸ”₯So you can now generate text and molecules in one-shot !!
[1] x.com/osclsd/statu... and arxiv.org/html/2602.12...
[2] x.com/PTenigma/sta...
[3] x.com/PTenigma/sta...
*

16.02.2026 18:30 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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πŸ”₯The cool new paper [1] extends this framework to discrete data by embedding tokens in the probability simplex, allowing flows to be defined on a continuous manifold where this exact same geometric transport theory applies.

16.02.2026 18:30 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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If the time-dependent flow is on the time interval [0,1], you can easily make intermediate samples by linear interpolation at times 0 < s < t < 1 and marginalise (weight these) over the data density to get the displacement of the source distribution Phi(t) given Phi(s).

16.02.2026 18:30 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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If the time-dependent flow is on the time interval [0,1], you can easily make intermediate samples by linear interpolation at times 0 < s < t < 1 and marginalise (weight these) over the data density to get the displacement of the source distribution Phi(t) given Phi(s).

16.02.2026 18:30 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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...between a reference distribution (usually n-dimensional Gaussian) and the target distribution you want to model (available as examples). ..πŸ”₯And flow matching builds this flow by systematically taking pairs of points in the source and target (the target is your training examples).

16.02.2026 18:30 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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πŸ”₯This really ingenious paper (Categorical Flow Matching [1]) came out today.
πŸ”₯ TL;DR: generates molecules, text, images
πŸ”₯As I said yesterday [2,3], you can use generative AI to make images (or molecules) with certain properties and learn their full distribution by learning a flow ... (thread below)

16.02.2026 18:30 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Nicely organised cats

04.02.2026 05:03 πŸ‘ 48 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0

Although I never drove an Uber, they sent tax forms to the IRS saying I earned ~$30k (got another one today). I reported the identity theft to IRS/FTC/Uber (hopefully fixed it). Still curious who’s driving an Uber as me -ask them some tough neuro questions if Paul Thompson pops up in your Uber app!!

03.02.2026 02:05 πŸ‘ 7 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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If you like modern AI with latent diffusion + flow matching, take a look at [1] well before latent diffusion, you will see how natural variation can arise naturally from statistical laws built with PDEs, continuum mechanics, + Bayesian priors that arise from these operators+their Green's functions.

31.01.2026 05:00 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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This later led to metric pattern theory, a general framework to understand variation in objects, a general theory of metrics on diffeomorphisms, and procedures to construct flows that do not fold (diffeomorphisms) by integrating velocity fields.

31.01.2026 05:00 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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..the deformations u(x) result from a stochastic differential equation Lu = e, where L is a self-adjoint differential operator, whose covariance can be learned from data, and may be non-stationary.

31.01.2026 05:00 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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But work by Michael Miller, Ulf Grenander, and the Brown Pattern Theory school showed that natural variation in brain geometry, and function, could be modelled as a set of probabilistic transformations of a template, where ..

31.01.2026 05:00 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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In the 1990s, as statistical parametric mapping was being developed, the standard way to study disease effects on the brain was to average images together.

31.01.2026 05:00 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Brilliant talk by Michael Miller at USC today. Michael has inspired countless generations of students, including me in the 1990s when his work with Ulf Grenander [1] helped new generations of mathematicians get involved with medical imaging and neuroscience.
[1] www.ams.org/journals/qam...

31.01.2026 05:00 πŸ‘ 8 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Brilliant to catch up with giants in neuroimaging + genetics, Anders Dale and Ole Andreassen. Thank you to Pravesh Parekh from the J Craig Venter Institute for a great talk on detecting time-dependent genomic effects on the brain, and his FEMA method to accelerate massively parallel GWAS analyses.

30.01.2026 04:42 πŸ‘ 8 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0