Wouter De Coster

"it depends"

Wonder which tandem repeat genotyper to use on your Oxford Nanopore genomes? We benchmarked 7 tools on >100 ONT genomes. We assessed usability, assembly concordance, Mendelian consistency, and sensitivity to pathogenic expansions. www.biorxiv.org/content/10.6...
🖥️ 🧬
@cubiomedinfo.bsky.social

Hope you corrected it to 42.

Is this you?

We need to talk about naked mole rats
theoatmeal.com/comics/naked...

"The men implicated in the Epstein files reinforces that I spend half my life explaining to men that their simplified, optimistic view of other men doesn’t line up with the experience of women and girls trying to dodge sexual harassment, assault and abuse attempts." - Leslie Morgan Steiner

Building a new plotting library in pure Rust.
Making themes and colourblind mode available on every plot type from day 1.
What other accessibility options can I add?

Noooo not another tool to benchmark against :)

Sounds promising :-)

It seems like @psy-fer.bsky.social is on fire - rewriting the STAR aligner in Rust 🔥

Doctors say that vaccines protect children from dangerous diseases. A nepo baby who barbecues dogs and snorts cocaine off toilet seats says that vaccines make children vulnerable to 5G radiation. For busy parents, it can be hard to know who to trust.

If cat could text you back... They would not

Long-Read Sequencing Uppsala, November 2–4, 2026 #LRUA26: Empower your research with long-read sequencing technologies and connect with experts, peers, and industry leaders in Uppsala this November.

Save the date! The Long‑Read Sequencing Uppsala Meeting (#LRUA26) is happening Nov 2–4, with a great lineup of invited and selected speakers

Stay tuned — registration and abstract submission will open soon🧬🖥️

lrua.se

One of my least favorite issues is when it says it implemented something, but it just left a placeholder and forgot about it

I'm calling length changes from the CIGAR. Each thread does both read fetching and processing, so I don't think that could explain this

graph showing memory use of parsing a CRAM file using rust-htslib

I am fetching reads from cram files in Rust, using rust-htslib and a rayon thread pool. It surprises me that memory use is flat up to 5 threads, but then takes off linearly. Does anyone have a clue what is going on? @robp.bsky.social @johanneskoester.bsky.social
Code: github.com/wdecoster/in...

Whether it's Donald Trump getting half a billion dollars from United Arab Emirates or Joe Biden getting free ice cream from a shop in Delaware, influence peddling has been a problem for both men.

We are excited to have @minomatt.bsky.social as a keynote speaker at the Flanders Nanopore Day, alongside a wide range of @nanoporetech.com topics, spanning from microbes to plants to humans. All information - including free registration and free PromethION sequencing - at nanoporeflanders.be

Headline: "Scientists discover emperor penguin colony in Antarctica using satellite images"

Yesterday it was cows using tools, today its penguins using satellite imagery.

Oh wow: Cryo-EM structure of #TAF15 filaments from postmortem #FTLD brains by the group of Ben Ryskeldi-Falcon at the @mrclmb.bsky.social. What an amazing tour-de-force!! 🤯

www.biorxiv.org/content/10.6...

Join us at the Flanders Nanopore Day conference on April 17th in Antwerp, organized together with @nanoporetech.com! Details are available at nanoporeflanders.be, including registration (free), abstract submission, and project prizes with free PromethION sequencing for two selected projects.

#Iran is in the middle of #REVOLUTION. This isn't about inflation. It's about 47 years of oppression.
Listen to the chants: "death to the dictator," calls for regime change, and demands for the Shah's return.
Be the voice of the Iranian people.
#DigitalBlackoutIran

What genetic change to Indian wheat led to superior baking in a tandoor?

A naan sense mutation

Literally poison.

Nicolás Maduro Charged With Felony Oil Possession

Nicolás Maduro Charged With Felony Oil Possession

Last Year, and the Year to Come

„Never forget: whenever Elon Musk walks up to a podium to bullshit you about colonizing Mars or whatever, he is walking on the bodies of dead children. He yanked their food and medicine away while telling lies and cracking stupid jokes.“
@dereklowe.bsky.social as usual not pulling any punches

Individual success yes. The collective success is something that the individual on the wrong track doesn't get any reward for.

I felt the same, but I also guess for those heroes there are hundreds more that kept on hitting their head against a wall and never achieved anything, though :-/

Size of Life From an amoeba to a blue whale

and the winner of the "2025 best thing on Internet" has just arrived
neal.fun/size-of-life/

@carlbergstrom.com