Sarah Dimeloe

🧬 How does metabolism shape immune function? #UKimmunomet26

Join the UK’s leading immunometabolism meeting in Newcastle for cutting edge research, international speakers and dedicated sessions for ECRs.

Abstract deadline is 5 March 🔗 https://bit.ly/493uE45

Immunometabolism researchers are meeting in Newcastle on 16-17 April!

Join us for 2 days of fantastic immunometabolism research, Bright Sparks sessions & networking with the community. #UKimmunomet26

Submit your abstract by 5 March and register now 👉 https://bit.ly/493uE45

Applications still OPEN for MRC fully funded PhD studentships 🎓✨
Join world-class researchers across our 3 partner universities:
🔹 @unibirmingham.bsky.social
🔹 @uniofleicester.bsky.social
🔹 @uniofnottingham.bsky.social
🌍 Open to applicants worldwide
👉 Apply more.bham.ac.uk/mrc-aim/phd-...

Another great study from @nickjonesimmuno.bsky.social lab and collaborators, highlighting a novel metabolic target to modulate T cell function in context of autoimmunity

Age‐Associated Inflammatory Monocytes Are Increased in Menopausal Females and Reversed by Hormone Replacement Therapy Post-menopausal females (> 64 years) have an increase in frequency of inflammatory monocyte populations with defective phagocytosis as compared to pre-menopausal (< 40 years) females. Hormone Replace....

I am so proud to say that our paper is now available at Aging Cell. There is a paucity of data as to how the menopause impacts your immune system, and the aim of this study was to investigate the impact of the menopause on monocyte phenotype and function.
onlinelibrary.wiley.com/doi/10.1111/...

We have a new Postdoc position advertised as part of our recent long-term Wellcome funding to join an established Postdoc and technician. I’m so excited to explore the role of the glycocalyx in CNS-inflammation. So many tools and expertise to work with! www.jobs.manchester.ac.uk/Job/JobDetai...

The source of dietary fat influences anti-tumour immunity in obese mice - Nature Metabolism This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.

This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥
www.nature.com/articles/s42...

Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma Neutrophils are vital innate immune cells shown to infiltrate glioblastomas, however we currently lack the molecular understanding of their functional states within the tumour niche. Neutrophils are k...

Happy to share our latest preprint doing low cell number (mini-bulk) and single cell #proteomics on tumour associated neutrophils from human glioblastoma where we find multiple functional states that would be invisible to scRNAseq, some showing pro-tumoural states with potential therapeutic value

Congratulations Elaine!!

🦠 New research shows obesity disrupts dendritic cell responses to viruses by impairing cytokine production & metabolism - helping explain higher infection risk.

📖 Read the open-access study: https://bit.ly/40kBiiH

By @andrea-woodcock.bsky.social‬ et al.

#Immunology

Biological Sex Influences Human Bystander CD8+ T Cell Activation CD8+ T cells isolated from male donors exhibit greater IL-15–driven bystander activation, NKG2D expression, and cytotoxicity than female CD8+ cells. This study reveals a sex-based difference in innat....

'Male CD8+ T cells stimulated with IL-15 exhibited greater bystander activation, including increased NKG2D expression and greater antigen-independent cytotoxicity against tumor cells compared with female CD8+ T cells.'
#immunology #immunosky

onlinelibrary.wiley.com/doi/10.1002/...

Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells - Nature Communications Iron has been shown to be necessary for the activation and differentiation of CD8+ T cells. Here the authors investigate changes in CD8+ T cell metabolism in iron limiting conditions and find that asp...

Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells #immunometabolism
www.nature.com/articles/s41...

We're based in the Ashworth Laboratories, King's Buildings, University of Edinburgh. Photo shows the main staircase in the entrance to the Ashworth, stone steps from the 1920s, decorated with a series of bright, colurful banners depicting the science that's tackled in the building.

I'm very pleased to have two lab positions open this week, to join our team looking at immune regulation in infection and co-infection. We're especially interested in tissue-based immunity, cytokine regulation and immune metabolism. Join us! Postdoc (3y) and research technician (12mo) posts open.

First Post on blue-sky. We are hiring! Post-doctoral position available in the neuroimmunology of stroke. Please check out link below and share elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

Congrats Andrea, Mary, Andy and the team - even more interesting insights into effects of obesity on the immune system!

Obesity drives dysregulation in DC responses to viral infection AbstractIntroduction. Obesity is a worldwide epidemic, with over 1 billion people worldwide living with obesity. It is associated with an increased risk of

🚨 new paper alert!!
Congrats to Andrea Woodcock on delivering this from during the depths of the pandemic! Thanks to @mary-canavan.bsky.social for the collab. Obesity drives dysregulation in DC responses to viral infection
academic.oup.com/discovimmuno...

Always been stellar in my eyes 😘

Lymphopenia-induced lymphoproliferation drives activation of naive T cells and expansion of regulatory populations Immunology; Cell Biology

Many thanks to all our collaborators for their support with this project. The RNA-seq data we analysed from patients who had received auto-SCT were originally published in the paper below where you’ll find further analysis and context

www.cell.com/iscience/ful...

IL-7 promotes integrated glucose and amino acid sensing during homeostatic CD4+ T cell proliferation Interleukin (IL)-7 promotes T cell expansion during lymphopenia. We studied the metabolic basis in CD4+ T cells, observing increased glucose usage for…

Online now, our latest manuscript reporting findings on the metabolic basis of cytokine-driven CD4+ T cell expansion, assessed in vitro and during T cell proliferation following autologous stem cell transplantation.

www.sciencedirect.com/science/arti...

Best of luck Calum!

EastBio: Long-range consequences of intestinal helminth infection. at University of Edinburgh on FindAPhD.com PhD Project - EastBio: Long-range consequences of intestinal helminth infection. at University of Edinburgh, listed on FindAPhD.com

An excellent PhD opportunity available in our team: long-range consequences of parasite infection, gut-lung communication and helminth-viral co-infection. Part of the EastBio training programme. Closing date 17th January. Please get in touch!
www.findaphd.com/phds/project...

Great to have past and present lab members together today to celebrate Taylor’s PhD graduation with her. Nancy, Victoria and Isaac even donned their own robes to join the procession… Congrats Taylor and we wish you all the very best!

#EMDS2024 was brilliant. Thx to all the organisers. Planning is well underway for EMDS25: Scotland Edition. We look forward to welcoming you to beautiful Edinburgh next year.

👀 for details in the coming months.

@britsocimm.bsky.social @cytokinesociety.bsky.social @societymucosalimm.bsky.social

We will be hosting two online information sessions with Q&As, for those interested to find out more about the programme and application process - Friday Dec 6th 12pm and Monday Dec 9th 6pm - further details and link to register on the page above.

If you’re interested in a project please contact the lead supervisor to find out more, and make sure you complete the application form by 10th January!

There’s a really exciting range of PhD projects on offer through the MRC “AIM” doctoral training partnership between the Universities of Birmingham, Leicester and Nottingham. 4-year funded studentships with great training opportunities too. Check out the options: more.bham.ac.uk/mrc-aim/phd-...

Why does Acinetobacter lwoffii not become resistant to antibiotics? at University of Birmingham on FindAPhD.com PhD Project - Why does Acinetobacter lwoffii not become resistant to antibiotics? at University of Birmingham, listed on FindAPhD.com

Another PhD opportunity in the team! This time its an exciting collaboration with @halllab.bsky.social and @kimhardie.bsky.social looking at why not all bacteria become resistant! www.findaphd.com/phds/project... Deadline 10th Jan and open to Uk and overseas! Pls repost!

We had a great time today at this fantastic event. So many great science presentations, alongside interesting and thought-proving talks on the progressive history of Manchester and how to build and maintain positive and inclusive research culture in the lab. Thanks all for bringing it together!

It was great to work with Kendle Maslowski’s group @mmimic.bsky.social and others on this project, interrogating the curious question of why T cells aren’t engaged by bacterial cancer therapy, and how to make them so! It’s all down to metabolism of course 😉…

Great opportunity to join our wonderful immunology, infection and inflammation community in Birmingham!