Andrew Landstrom

Huge congratulations to @robinperelli.bsky.social for years of hard work, as well as @erd2.bsky.social and other superb scientists, cardiologists, and colleagues not on BlueSky!

Using iPSC-derived cardiac myocytes and a cardiac-specific inducible KO, we found that loss of TAX1BP3 results in TRPV4 mediated arrhythmias through calcium overload. Blockade of TRPV4 results in suppression of the arrhythmic phenotype

A new autosomal recessive cause of arrhythmic cardiomyopathy - variants in TAX1BP3. Published in Circ Res today!

URL: www.ahajournals.org/eprint/RCVCU...

@ahascience.bsky.social @ahajournals.bsky.social #cardiosky #genetics #medsky #cardiogen

Genes Associated With Hypertrophic Cardiomyopathy: A Reappraisal by the ClinGen Hereditary Cardiovascular Disease Gene Curation Expert Panel Hypertrophic cardiomyopathy (HCM) is an inherited cardiac condition affecting ∼1 in 500 and exhibits marked genetic heterogeneity. Previously publishe…

Q: How many genes should be tested for patients with hypertrophic cardiomyopathy? A: 29

Excited to share our latest: Re-Appraisal of HCM genes by our ClinGen Hereditary CVD Gene Curation Expert Panel out today in @jaccjournals.bsky.social
www.sciencedirect.com/science/arti...

Health care rivals UNC, Duke partnering to build NC’s first standalone children’s hospital UNC Health and Duke Health -- who have battled for patients in fast-growing North Carolina -- are uniting to build a 500-bed pediatric hospital and research center in the Triangle. The new hospital is...

While Duke and UNC compete on the basketball court, we have collaborated in the care of patients for years. Thrilled that there will be a joint partnership between both to create the first NC Children's Hospital

www.wral.com/story/health...

(also a great picture of our exercise phys lab)

Scientists at NIH can’t purchase supplies for their studies after Trump administration pauses outside communications | CNN Scientists at the National Institutes of Health have been told the communications pause announced by the Trump Administration earlier this week includes a pause on all purchasing, including supplies f...

The communications pause at health agencies has extended to external procurement orders for supplies for internal research @ NIH, sources tell @reportergoodman.bsky.social & me. Some researchers worry they won't be able to buy test tubes to draw blood or food for animals: www.cnn.com/2025/01/24/h...

Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring Researchers facing

Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring | Science | AAAS www.science.org/content/arti...

Probably a page found in most ER contingency plans

Did you all have to break out the “biblical flood” contingency protocols?

It was a lot of fun @n-bouatia-naji.bsky.social! You’ve got wonderful colleagues at
PARCC! #medsky #cardiosky

I joined 75+ @nobelprize.bsky.social laureates urging US Senators to oppose RFK Jr.'s confirmation as DHHS Secretary. If you’re in a state with GOP senators, PLEASE reach out to them! I’d deeply appreciate it if you amplified this post! 🙏
www.nytimes.com/2024/12/09/h...

Millie. Which I think suits her

Incredibly grateful to have been trained by the best mentor, and thrilled to continue my journey in pediatric cardiology at Stanford. Here’s to continued collaboration and friendship! @andrewlandstrom.bsky.social

Congratulations to @manasa-gurumoorthi.bsky.social for an incredible peds cards match! Thank you for everything you have taught us! Stanford is lucky to get you! #match #cardiosky #medsky @erd2.bsky.social

Once Burned, Twice Shy, Cardiologists Ditch X for Bluesky Though X (formerly Twitter) was once a place many cardiologists found community and opportunity, many are jumping ship.

My comments to @tctmd.bsky.social about why I left that other social site for bluer skies 🦋. Also comments from @load-dependent.bsky.social @cardioobdoc.bsky.social @vietheartpa.bsky.social @jgrapsa.bsky.social
#CardioSky
www.tctmd.com/news/once-bu...

Millie the guard dog

As threatening as they come

Molecular convergence of risk variants for congenital heart defects leveraging a regulatory map of the human fetal heart Congenital heart defects (CHD) arise in part due to inherited genetic variants that alter genes and noncoding regulatory elements in the human genome. These variants are thought to act during fetal de...

New work on congenital heart disease genetics from @jengreitz.bsky.social & co

-regulatory mapping from developmental ❤️ tissues

-implication of valvular interstitial cells & epicardial fibroblasts in CHD pathogenesis

Hugely integrative & comprehensive analysis!

www.medrxiv.org/content/10.1...

🎨 In case anyone need…

The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!

Check it out 👇
bioart.niaid.nih.gov

Spontaneous Coronary Artery Dissection: Current Knowledge, Research Gaps, and Innovative Research Initiatives: JACC Advances Expert Panel Despite marked advancements in the recognition and diagnosis of spontaneous coronary artery dissection (SCAD) over the past decade, knowledge of the b…

🚨🚨🚨 Our new review is out highlighting research priorities for SCAD, lead by Esther Kim, Daniela Crousillat, and Amy Sarma

Spontaneous Coronary Artery Dissection: Current Knowledge, Research Gaps, and Innovative Research Initiatives: JACC Advances Expert Panel

www.sciencedirect.com/science/arti...

Seriously

Don’t let the puppy distract you. We’ve had Christmas lights up since Nov 1. No apologies

🧬 Our dilated #cardiomyopathy GWAS out today!

📍https://www.nature.com/articles/s41588-024-01952-y

All made possible with friends and collaborators from HERMES Consortium @alberthenry.bsky.social @tomlumbers.bsky.social @jamesware.bsky.social @mrc-lms.bsky.social @imperialnhli.bsky.social #BHF

🧵 👇

Thanks for the wonderful visit @n-bouatia-naji.bsky.social! It’s a long way to come from Inserm via #AHA24. From the science to the mentorship to the collaborations!

@ahascience.bsky.social @erd2.bsky.social #CardioSky #medsky

Trust edges up—slightly The Pew Research Center survey on trust in science and researchers is eagerly awaited every year by science policy experts and communicators. This year’s results, released last week, give a small, but...

Here's my editorial on the new Pew trust in science data with great quotes from @katharinehayhoe.com: "Scientists aren’t only brains in jars; we’re human beings embedded in society, bringing both reason and principles to our work.” www.science.org/doi/10.1126/...

Nabila Bouatia-Naji giving the Victor Dzau Seminar Series at Duke. Tackling complex genetic cardiovascular diseases through genomics and multi-omics! @n-bouatia-naji.bsky.social @ahascience.bsky.social #medsky #cardiosky

Report: Every dollar of NIH research funding doubles in economic returns Research funded by the National Institutes of Health (NIH) generated $2.46 in economic activity for every $1 of funding in 2023, a total of $92.9 billion, according to an

Research funded by NIH generated $2.46 in economic activity for every $1 of funding in 2023 [a total of $92.9 billion]

www.fiercebiotech.com/research/rep...

A landmark gene therapy study! Out today with NEJM

AAV mediated gene replacement of LAMP2 in boys with Danon disease Phase 1 trial demonstrates a reasonable safety profile

www.nejm.org/doi/pdf/10.1...

This is a big deal

#cardiosky #medsky #genetherapy #Dana at #AHA24 @ahascience.bsky.social

Nothing says lab reunion drinks like an English pub with a Christmas tree! Thanks to @lwilsbacher.bsky.social for a great recommendation! #AHA24 brought us all together! @manasa-gurumoorthi.bsky.social @ahascience.bsky.social #cardiosky #medsky

Saige Mitchell, Duke Med Student showing that children with single ventricle heart disease with a VUS on CMA do not have worse survival than children with a normal CMA (not so for syndromic/abnormal CMAs)