The peer reviewed and updated version of this work is now online (although not quite the fully formatted version). We had an existential crisis about kinesin-1 regulation while developing this work, but we are super proud of everything we put into this project. www.cell.com/iscience/ful...
Standing with all my fellow scientists in solidarity 🧪 www.nature.com/articles/d41...
Wow. Read this 👇
Nice to see this finally published!
Congratulations @jack-humphrey.bsky.social
www.nature.com/articles/s41...
(Collaborative work with Panos Roussos and his team! )
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing
It is very important that our research programme is visible and accessible to everyone, because it is funded by the generosity of our supporters.
Great to catch up earlier today with some of our MND Association funded researchers at SITraN, doing great work to understand and treat #ALS #MND
US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.
https://go.nature.com/4kd1vIu
Really excited this is out! We found polyunsaturated fatty acids (PUFAs) were beneficial in models of C9orf72 FTD/ALS and the greatest benefit occurred when increasing levels specifically within neurons @ukdri.ac.uk @uclqsion.bsky.social @ucl.ac.uk @cziscience.bsky.social
rdcu.be/ebbZf
I'm looking to see if the cuts & chaos at CDC and NIH have affected any clinical trials or research for drugs for the treatment of cancer, Alzheimer's, Parkinson's, or other serious diseases. If you know anything, please contact me at DavidCorn.99 at Signal.
Or if you have any other good stories.
Check out our new review of C9orf72 ALS in @thelancetneuro.bsky.social with Sarah Mizielinska, Rosa Rademakers and others! Was fun to co-write but tough to collate such incredible progress into a one article: authors.elsevier.com/c/1ke765FFzL...
New paper in collaboration with James Alix and others. No phenotype in the Liu et al (2016) C9orf72 BAC ALS model on either the Jax labs or Janvier FVB genetic backgrounds. The background itself has a known neurological phenotype which we confirmed.
journals.biologists.com/dmm/article/...
An infographic with the following text: Health apprenticeships at a glance 1,048 students have started health apprenticeships at the University of Sheffield 146 - the number of NHS Trusts, healthcare organisations and other employer partners we work with 84% Achievement rate - 34% above the national average (2022/23 academic year) “Good” - the Ofsted Rating we received at our latest inspection (published in January 2025), in recognition of the quality of our apprenticeships According to the GOV.UK 'Find apprenticeship training' service we have been rated "Excellent" by employers and "Good" by apprentices
What better way to bring #NationalApprenticeshipWeek to a close than by taking note of our achievements as a health apprenticeships provider?🎉
Here's just some of the reasons we have to celebrate this #CelebrationFriday ⬇️
@sheffielduni.bsky.social
🚨 A groundbreaking drug screening programme is set to transform MND treatment!
🔬 EXPERTS-ALS will rapidly assess potential ALS drugs, testing their ability to slow nerve damage before large trials.
www.sheffield.ac.uk/news/groundb...
Please sign if you believe the Royal Society needs to stand up for values we all hold dear
Our statement on Ellorarxine in #ALS #MND
Testing a drug takes a lot of time, a lot of commitment from people living with MND, and a lot of money. We must be sure that we put our efforts in the right place to find new and effective treatments as quickly as possible.
ukmndri.org/2025/02/07/a...
My team @naturecomms.bsky.social is looking for a new editor! We need someone to help handle all of the awesome #stemcell and #devbio papers we're getting. DM me if you're interested or have questions about the role or interview process.
springernature.wd3.myworkdayjobs.com/en-US/Spring...
Reminder that @europepmc.org is a mirror of Pubmed with better search and that it indexes *all* bioRxiv preprints (as well as ResearchSquare), not just the ones funded by NIH like chauvinist Pubmed
This is a big deal, y'all. Federal health websites are being stripped of content or removed in their entirety. Stick with this thread for a look at what's disappeared so far! 1/x
Nice paper from the Barmada lab (not on here?) and highly actionable target for TDP-43 proteinopathy in ALS? We certainly need more of those!
Well not all tech titans are alike. Bill Gates is indeed doing God's work! www.theguardian.com/us-news/2025...
Nice job. Are you available to quote for some work?
Please check out our new paper using CMAP to bridge from preclinical to clinical studies in ALS.
Mouse models have been blamed for clinical failures, but how you use them is key. This approach is one step towards improving discovery of new drugs for ALS
www.tandfonline.com/doi/full/10....
